Patents by Inventor Sundeep Dugar

Sundeep Dugar has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20220265630
    Abstract: Disclosed herein are pyridyl compounds. Also described are specific conjugated nicorandil compounds. Also disclosed are pharmaceutical compositions that include the compounds. Methods of using the pyridyl compounds are disclosed for the treatment of diseases or conditions related to kidney or kidney functions.
    Type: Application
    Filed: March 16, 2020
    Publication date: August 25, 2022
    Inventors: Shalabh GUPTA, Sundeep DUGAR
  • Publication number: 20220194939
    Abstract: Disclosed herein are novel compounds that inhibit fructokinase (KHK or ketohexokinase) and the downstream metabolic effects mediated by fructose metabolism. Fructokinase inhibitors specifically block the metabolism of both dietary and endogenous fructose metabolism and have a host of potential metabolic benefits.
    Type: Application
    Filed: April 17, 2020
    Publication date: June 23, 2022
    Inventors: Sundeep Dugar, Chase Needham, Paul Maffuid, Rajendra Kumar Reddy Gadikota, Sreenivasulu Reddy Koduru, Michael F. Wempe, Vijay Kumar
  • Publication number: 20220079927
    Abstract: Disclosed herein are pyridyl compounds. Also described are specific conjugated nicorandil compounds. Also disclosed are pharmaceutical compositions that include the compounds. Methods of using the pyridyl compounds are disclosed for the treatment of diseases or conditions related to kidney or kidney functions.
    Type: Application
    Filed: November 30, 2021
    Publication date: March 17, 2022
    Inventors: Shalabh GUPTA, Sundeep DUGAR
  • Patent number: 11273144
    Abstract: The present invention relates to compounds and compositions and their applications as pharmaceuticals for treating, preventing, or reversing injury to skeletal or cardiac muscles, for treating or preventing diseases relating to the structure and function of skeletal or cardiac muscle, and for inducing regeneration or restructuring of skeletal or cardiac muscle as a means of treating diseases relating to abnormalities in skeletal or cardiac muscle structure and function in a human or animal subject. Further aspects relate to the same or similar applications for bone and bone diseases.
    Type: Grant
    Filed: January 14, 2020
    Date of Patent: March 15, 2022
    Assignee: EPIRIUM BIO INC.
    Inventors: George Frederic Schreiner, Guillermo Ceballos, Sundeep Dugar
  • Publication number: 20210380535
    Abstract: The invention provides novel co-crystals of epicatechin with a carboxy-N-heterocyclic co-crystal former such as trigonelline or proline and their pharmaceutical compositions. Methods of preparing the co-crystals and methods of using them are also provided.
    Type: Application
    Filed: October 24, 2019
    Publication date: December 9, 2021
    Inventors: Sundeep DUGAR, Somdutta SEN, Bilash KUILA
  • Patent number: 11142501
    Abstract: Provided herein are novel monomethyl fumarate prodrugs.
    Type: Grant
    Filed: February 12, 2021
    Date of Patent: October 12, 2021
    Assignee: Ixchel Pharma, Inc.
    Inventor: Sundeep Dugar
  • Patent number: 11083720
    Abstract: Disclosed herein are novel indazole-based compounds that inhibit fructokinase (aka ketohexokinase) and the downstream metabolic effects mediated by fructose metabolism. Fructokinase inhibitors specifically block the metabolism of both dietary and endogenous fructose metabolism and have a host of potential metabolic benefits. These benefits including blocking sugar craving and sugar induced metabolic syndrome and diabetes, but also blocking fructose metabolism can benefit the rare orphan disease Hereditary Fructose Intolerance, obesity, insulin resistance, metabolic syndrome, fatty liver, hypertension, cardiac injury from ischemia, certain cancers (including hepatocellular and pancreas), acute kidney injury from ischemia, heat stress, rhabdomyolysis or radiocontrast, and chronic diabetic and nondiabetic renal disease.
    Type: Grant
    Filed: March 19, 2018
    Date of Patent: August 10, 2021
    Assignees: Regents of the University of Colorado, a body corporate, Colorado Research Partners. LLC
    Inventors: Sundeep Dugar, Miguel Lanaspa-Garcia, MyPhuong Thi Le, William John Greenlee
  • Publication number: 20210177801
    Abstract: The present invention pertains to the enhanced activity of (+) epicatechin over (?) epicatechin. The present invention is related to novel analogs of (+) epicatechin of the formula (I), which enhances the pharmacokinetics and therefore the pharmacodynamics of (+) epicatechin. The present invention is related to analogs of (+) epicatechin of the formula (I). The general structure of the analogs of the present invention may be represented by Formula (I): Formula (I) wherein A and B are independently OR1 and C and D are independently OH; wherein R1 is independently C1 to C10 lower straight or branched chain acyclic or cyclic alkyl, or is selected from the group comprising, hydroxy butyric acid, dichloroacetic acid; phenyl butyric acid; valproic acid.
    Type: Application
    Filed: December 21, 2020
    Publication date: June 17, 2021
    Inventors: Sundeep DUGAR, George SCHREINER, Somdutta SEN
  • Publication number: 20210163414
    Abstract: Provided herein are novel monomethyl fumarate prodrugs.
    Type: Application
    Filed: February 12, 2021
    Publication date: June 3, 2021
    Inventor: Sundeep DUGAR
  • Publication number: 20210047269
    Abstract: The present invention provides novel compounds with improved solubility and altered pharmacokinetic properties.
    Type: Application
    Filed: August 24, 2020
    Publication date: February 18, 2021
    Inventors: Sundeep DUGAR, Dinesh MAHAJAN, Somdutta SEN
  • Publication number: 20210024572
    Abstract: The present invention relates to novel steroidal compounds of formula (I), process for preparation of the same and composition comprising these compounds.
    Type: Application
    Filed: March 3, 2020
    Publication date: January 28, 2021
    Inventors: Sundeep DUGAR, Dinesh MAHAJAN, George Frederic SCHREINER
  • Patent number: 10898465
    Abstract: The present invention pertains to the enhanced activity of (+) epicatechin over (?) epicatechin. The present invention is related to novel analogs of (+) epicatechin of the formula (I), which enhances the pharmacokinetics and therefore the pharmacodynamics of (+) epicatechin. The present invention is related to analogs of (+) epicatechin of the formula (I). The general structure of the analogs of the present invention may be represented by Formula (I): Formula (I) wherein A and B are independently OR1 and C and D are independently OH; wherein R1 is independently C1 to C10 lower straight or branched chain acyclic or cyclic alkyl, or is selected from the group comprising, hydroxy butyric acid, dichloroacetic acid; phenyl butyric acid; valproic acid.
    Type: Grant
    Filed: June 21, 2017
    Date of Patent: January 26, 2021
    Assignee: Epirium Bio Inc.
    Inventors: Sundeep Dugar, George Schreiner, Somdutta Sen
  • Publication number: 20200390741
    Abstract: The present invention relates to compounds and compositions and their applications as pharmaceuticals for treating, preventing, or reversing injury to skeletal or cardiac muscles, for treating or preventing diseases relating to the structure and function of skeletal or cardiac muscle, arid for inducing regeneration or restructuring of skeletal or cardiac muscle as a means of treating diseases relating to abnormalities in skeletal or cardiac muscle structure and function in a human or animal subject. Further aspects relate to the same or similar applications for bone and bone diseases.
    Type: Application
    Filed: January 14, 2020
    Publication date: December 17, 2020
    Inventors: George Frederic SCHREINER, Guillermo CEBALLOS, Sundeep DUGAR
  • Patent number: 10752589
    Abstract: The present invention provides novel compounds with improved solubility and altered pharmacokinetic properties. The compounds of the present invention may be represented by Formula (I).
    Type: Grant
    Filed: March 14, 2017
    Date of Patent: August 25, 2020
    Assignee: SPHAERA PHARMA PVT. LTD.
    Inventors: Sundeep Dugar, Dinesh Mahajan, Somdutta Sen
  • Patent number: 10618933
    Abstract: The present invention relates to novel steroidal compounds of formula (I), process for preparation of the same and composition comprising these compounds.
    Type: Grant
    Filed: July 23, 2015
    Date of Patent: April 14, 2020
    Assignee: EPIRIUM BIO INC.
    Inventors: Sundeep Dugar, Dinesh Mahajan, George Frederic Schreiner
  • Publication number: 20200016141
    Abstract: Disclosed herein are novel indazole-based compounds that inhibit fructokinase (aka ketohexokinase) and the downstream metabolic effects mediated by fructose metabolism. Fructokinase inhibitors specifically block the metabolism of both dietary and endogenous fructose metabolism and have a host of potential metabolic benefits. These benefits including blocking sugar craving and sugar induced metabolic syndrome and diabetes, but also blocking fructose metabolism can benefit the rare orphan disease Hereditary Fructose Intolerance, obesity, insulin resistance, metabolic syndrome, fatty liver, hypertension, cardiac injury from ischemia, certain cancers (including hepatocellular and pancreas), acute kidney injury from ischemia, heat stress, rhabdomyolysis or radiocontrast, and chronic diabetic and nondiabetic renal disease.
    Type: Application
    Filed: March 19, 2018
    Publication date: January 16, 2020
    Inventors: Sundeep DUGAR, Miguel LANASPA-GARCIA, MyPhuong Thi LE, William John GREENLEE
  • Publication number: 20190262347
    Abstract: The present invention discloses a novel, stable and synergistic combination of epicatechin with anti-cancer compounds. The present invention also discloses a composition comprising the novel combination of epicatechin with anti-cancer compounds along with other pharmaceutically acceptable excipients.
    Type: Application
    Filed: November 1, 2017
    Publication date: August 29, 2019
    Applicant: SPHAERA PHARMA PVT. LTD.
    Inventor: Sundeep DUGAR
  • Publication number: 20190247359
    Abstract: The present invention pertains to the enhanced activity of (+) epicatechin over (?) epicatechin. The present invention is related to novel analogs of (+) epicatechin of the formula (I), which enhances the pharmacokinetics and therefore the pharmacodynamics of (+) epicatechin. The present invention is related to analogs of (+) epicatechin of the formula (I). The general structure of the analogs of the present invention may be represented by Formula (I): Formula (I) wherein A and B are independently OR1 and C and D are independently OH; wherein R1 is independently C1 to C10 lower straight or branched chain acyclic or cyclic alkyl, or is selected from the group comprising, hydroxy butyric acid, dichloroacetic acid; phenyl butyric acid; valproic acid.
    Type: Application
    Filed: June 21, 2017
    Publication date: August 15, 2019
    Inventors: Sundeep DUGAR, George SCHREINER
  • Publication number: 20190077757
    Abstract: The present invention provides novel compounds with improved solubility and altered pharmacokinetic properties. The compounds of the present invention may be represented by Formula (I).
    Type: Application
    Filed: March 14, 2017
    Publication date: March 14, 2019
    Inventors: Sundeep DUGAR, Dinesh MAHAJAN, Somdutta SEN
  • Patent number: 10207993
    Abstract: The present invention relates to novel compounds of formula (1): The present invention also discloses compounds of formula (1) along with other pharmaceutical acceptable excipients and use of the compounds as anti-tubercular agents.
    Type: Grant
    Filed: August 10, 2017
    Date of Patent: February 19, 2019
    Assignees: SPHAERA PHARMA PVT. LTD., DRUG DISCOVERY RESEARCH CENTRE
    Inventors: Sundeep Dugar, Dinesh Mahajan, Santosh Kumar Rai, Kanury Rao, Varshneya Singh