Abstract: The disclosure provides methods for the treatment and/or prevention of iron overload diseases such as hereditary hemochromatosis.

Abstract: The disclosure relates to compositions comprising and methods of treating inflammatory bowel diseases by administering an engineered peptide of formula (I) or a pharmaceutically acceptable salt thereof that bind ?4?7 integrin.

Abstract: The invention relates to methods of treating inflammatory bowel diseases, including with engineered peptides (e.g. peptide monomers and dimers comprising disulfide or thioether intramolecular bonds) that bind ?4?7 integrin. In one aspect, the disclosure provides a method of treating an inflammatory bowel disease (IBD) in a subject in need thereof, comprising administering to the subject an ?4?7 integrin antagonist, wherein the antagonist is administered to the patient orally at a dose of about 100 mg to about 500 mg, once or twice daily, wherein the antagonist is a peptide dimer compound comprising two peptides, or a pharmaceutically acceptable salt thereof.

Abstract: The present invention provides hepcidin analogues, and related pharmaceutical compositions and use thereof in treating polycythemia vera.

Abstract: The present invention provides hepcidin analogues, and related pharmaceutical compositions and use thereof in treating polycythemia vera.

Abstract: A platform and application provide for micro-coaching on healthy eating and lifestyle. Clients log meals using a mobile application by taking a picture of the meal and/or optionally describing the meal using text. Clients may also log workouts, exercise, and activity details. The client's coach can view the logs in the client's activity log and add a comment. The coach's comment on a logged meal may be displayed in association with the meal in the client's activity log. Optionally, the client can reply to the coach's comment, and the reply is displayed in the same meal message thread. Accordingly, the platform and application enable the client to conveniently log meals, exercise, and activity data and obtain feedback from a coach on a meal or exercise log.