Abstract: The present disclosure provides a compound of a chemical structure having the ability of inhibiting or disintegrating an androgen receptor (AR), or a pharmaceutically acceptable salt of the compound. The present disclosure also provides a composition comprising such a compound or a pharmaceutically acceptable salt thereof. The present disclosure provides a pharmaceutical use of a compound according to the present disclosure, a salt thereof, and a composition comprising same for the treatment or prevention of AR-related diseases. The present disclosure also provides a method for treating or preventing AR-related diseases, comprising administering to a subject in need of treatment an effective amount of a compound according to the present disclosure, a salt thereof, or a composition comprising same.

Abstract: The present invention relates to a target protein degradation-inducing Degraducer, a preparation method thereof, and a pharmaceutical composition for preventing or treating diseases related to EED, EZH2, or PRC2 comprising same as an active ingredient. A novel compound represented by formula 1, according to the present invention is a Degraducer compound that induces degradation of a target protein, i.e., EED or PRC2, utilizing cereblon E3 ubiquitin ligase, VHL E3 ubiquitin ligase, MDM2 E3 ubiquitin ligase, and cIAP E3 ubiquitin ligase, wherein the compound has an aspect of remarkably achieving target protein degradation-inducing activity through a ubiquitin proteasome system (UPS), and therefore there is a useful effect in that it is possible to provide a pharmaceutical composition for preventing or treating diseases or conditions related to a target protein, and a functional health food composition for preventing or improving same, comprising said compound as an active ingredient.

Abstract: A mass spectrometry device includes a sample seating part including an ultrasonic vibrator having a through hole through which liquid particles formed by the ultrasonic vibrator from an adsorbent material including a sample and a solvent are discharged, the adsorbent material being seated on the ultrasonic vibrator; a reaction part in which plasma or an ionization medium generated by plasma come into contact with the liquid particles discharged from the through hole to form an ionized material; an introduction part discharging and introducing the ionized material to a detection part; and the detection part analyzing the ionized material discharged from the introduction part. The mass spectrometry device and the mass spectrometry method can detect the components of various samples by converting a sample into liquid particles using ultrasonic waves and applying plasma and can detect samples in various fields without regard to locations.

Abstract: A method for transmitting data between a microprocessor and an external memory module through external package pins of the microprocessor, which includes the steps of: a) deciding N-bit full sized data to be transferred by using M, wherein N and M are positive integers and N is greater than M; b) sequentially transferring N/M number of M-bit divided data; c) temporarily storing N/M number of M-bit divided data; and d) combining the N/M number of M-bit divided data into the N-bit full sized data.

Abstract: A combined cache with main memory and a control method thereof, which can be configured with various structures of cache by only adding a minimized control circuit in order to be used as main memory. The N-way cache memory system includes N cache memory blocks receiving a tag field and an offset field of an address bus, a logic OR element for performing a logic OR operation with way hit signals from each cache memory block and for generating a cache hit signal when a way hit signal is produced in one of the cache memory blocks, and a first selection element for outputting data to a data bus, which results from the cache memory blocks in response to the way hit signal.