Patents by Inventor Sung-Hou Kim
Sung-Hou Kim has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 8105983Abstract: An optimum solubility screen in which a panel of buffers and many additives are provided in order to obtain the most homogeneous and monodisperse protein condition for protein crystallization. The present methods are useful for proteins that aggregate and cannot be concentrated prior to setting up crystallization screens. A high-throughput method using the hanging-drop method and vapor diffusion equilibrium and a panel of twenty-four buffers is further provided. Using the present methods, 14 poorly behaving proteins have been screened, resulting in 11 of the proteins having highly improved dynamic light scattering results allowing concentration of the proteins, and 9 were crystallized.Type: GrantFiled: March 29, 2006Date of Patent: January 31, 2012Assignee: The Regents of the University of CaliforniaInventors: Sung-Hou Kim, Rosalind Kim, Jamila Jancarik
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Publication number: 20110196872Abstract: A computational method and system for the comparison and analysis of different objects of information within a database or collection. All objects are compared in a pair-wise fashion so the relative similarity between each object to every other object in the collection is known. A generalized alignment-free method is described for comparing whole genome (coding and non-coding) DNA sequences is used to investigate the relationship among placental mammalian genomes. Differences in word feature frequency profiles (FFP) are used to derive distance and infer evolutionary relationships.Type: ApplicationFiled: October 9, 2009Publication date: August 11, 2011Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Gregory E. Sims, Sung-Hou Kim
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Publication number: 20060223120Abstract: Herein is described and optimum solubility screen in which a panel of buffers and many additives are provided in order to obtain the most homogeneous and monodisperse protein condition for protein crystallization. The present methods are useful for proteins that aggregate and cannot be concentrated prior to setting up crystallization screens. A broad range of buffers is intended for use in this screen. A high-throughput method using the hanging-drop method and vapor diffusion equilibrium and a panel of twenty-four buffers is further provided. After monitoring precipitation, the conditions leading to clear drops are selected for evaluation, preferably dynamic light scattering (DLS) characterization. If the DLS results are not optimal, a series of additives are tested in the presence of the best buffer selected from the initial screen and again DLS is used to determine the best condition.Type: ApplicationFiled: March 29, 2006Publication date: October 5, 2006Inventors: Sung-Hou Kim, Rosalind Kim, Jamila Jancarik
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Publication number: 20050026938Abstract: The present invention relates to purine analogs that inhibit, inter alia, protein kinases, G-proteins and polymerases. In addition, the present invention relates to methods of using such purine analogs to inhibit protein kinases, G-proteins, polymerases and other cellular processes and to treat cellular proliferative diseases.Type: ApplicationFiled: August 30, 2004Publication date: February 3, 2005Applicants: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA a California corporation, Centre National De La Recherche ScientifiqueInventors: Nathanael Gray, Peter Schultz, Sung-Hou Kim, Laurent Meijer
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Patent number: 6803371Abstract: The present invention relates to 2-N-substituted 6-(4-methoxybenzylamino)-9-isopropylpurines that inhibit, inter alia, protein kinases, G-proteins and polymerases. In addition, the present invention relates to methods of using such 2-N-substituted 6-(4-methoxybenzylamino)-9-isopropylpurines to inhibit protein kinases, G-proteins, polymerases and other cellular processes and to treat cellular proliferative diseases.Type: GrantFiled: January 27, 2003Date of Patent: October 12, 2004Assignees: The Regents of the University of California, Centre National de la RechercheInventors: Nathanael S. Gray, Peter Schultz, Sung-Hou Kim, Laurent Meijer
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Publication number: 20030176699Abstract: The present invention relates to purine analogs that inhibit, inter alia, protein kinases, G-proteins and polymerases. In addition, the present invention relates to methods of using such purine analogs to inhibit protein kinases, G-proteins, polymerases and other cellular processes and to treat cellular proliferative diseases.Type: ApplicationFiled: January 27, 2003Publication date: September 18, 2003Applicant: The Regents of the University of CaliforniaInventors: Nathanael S. Gray, Peter Schultz, Sung-Hou Kim, Laurent Meijer
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Patent number: 6617331Abstract: The invention provides compounds having the structure: where, R1 is a member selected from the group consisting of H and NH2; R2 is member selected from the group consisting of H, CO2H, OH and halogen; and R3 is a member selected from the group consisting of CO2H, NH2 and halogen. Also provided are methods of using the compounds and formulations containing the compounds.Type: GrantFiled: May 1, 2001Date of Patent: September 9, 2003Assignees: The Regents of the University of California, Centre National de la Recherche ScientifiqueInventors: Nathanael S. Gray, Peter Schultz, Sung-Hou Kim, Laurent Meijer
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Publication number: 20030114672Abstract: The present invention relates to purine analogs that inhibit, inter alia, protein kinases, G-proteins and polymerases. In addition, the present invention relates to methods of using such purine analogs to inhibit protein kinases, G-proteins, polymerases and other cellular processes and to treat cellular proliferative diseases.Type: ApplicationFiled: May 1, 2001Publication date: June 19, 2003Inventors: Nathanael S. Gray, Peter Schultz, Sung-Hou Kim, Laurent Meijer
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Patent number: 6294341Abstract: The present invention relates to a method for detecting a substance having an activity to inhibit HIV infection rapidly, economically and safely. The present invention uses the characteristics that if a function of transmembrane protein gp41 of HIV is inhibited, HIV infection is also inhibited, and therefore the function of gp41 depends on the interaction between two helical structures of gp41. The method of the present invention is to detect a substance to inhibit HIV infection by an immunoassay using the interaction between the variant protein Trx-N, which is prepared by binding the N-terminal helical domain of gp41 to Trx (thioredoxin) and the variant protein GST-C, which is prepared by binding the C-terminal helical domain of gp41 with GST-C (Glutathione S-transferase). This immunoassay can be used for automatic detection of the substance to inhibit the activity of gp41 can be carried out by the method.Type: GrantFiled: March 19, 1999Date of Patent: September 25, 2001Assignee: Korea Institute of Science and TechnologyInventors: Yeon Gyu Yu, Sung-Hou Kim, Jae-Ryeon Ryu
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Patent number: 6255485Abstract: The present invention relates to purine analogs that inhibit, inter alia, protein kinases, G-proteins and polymerases. In addition, the present invention relates to methods of using such purine analogs to inhibit protein kinases, G-proteins, polymerases and other cellular processes and to treat cellular proliferative diseases.Type: GrantFiled: August 6, 1998Date of Patent: July 3, 2001Assignees: The Regents of the University of California, Centre National de la Recherche ScientifiqueInventors: Nathanael S. Gray, Peter Schultz, Sung-Hou Kim, Laurent Meijer
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Patent number: 6033889Abstract: Gene sequences of superoxide dismutase of Aquifex pyrophilus which is one of hyperthermophile microorganism and protein expressed therefrom are provided, wherein the protein is used as a necessary medicament in treatment of inflammation, disease of autoimmunization, chromosome lesion and the like, and particularly, A. pyrophilus is a hyperthermophile which can grow at the optimum temperature of 85.degree. C., and thus the superoxide dismutase of A. pyrophilus has a higher thermal stability than other organisms, resulting in further broad applications in the pharmaceutical field.Type: GrantFiled: January 16, 1998Date of Patent: March 7, 2000Assignee: Korea Institute of Science and TechnologyInventors: Ye Sun Han, Yeon Gyu Yu, Sung Hou Kim, Jae Hwan Lim, Jae Ryeon Ryu, In Geol Choi
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Patent number: 6025146Abstract: The present invention is directed to methods for crystallizing macrophage colony stimulating factor. The present invention is also directed to methods for designing and producing M-CSF agonists and antagonists using information derived from the crystallographic structure of M-CSF. The invention is also directed to methods for screening M-CSF agonists and antagonists. In addition, the present invention is directed to an isolated, purified, soluble and functional M-CSF receptor.Type: GrantFiled: June 5, 1995Date of Patent: February 15, 2000Assignee: Chiron CorporationInventors: Jayvardhan Pandit, Jarmila Jancarik, Sung-Hou Kim, Kirston Koths, Robert Halenbeck, Anna Lisa Fear, Eric Taylor, Ralph Yamamoto, Andrew Bohm
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Patent number: 5866114Abstract: The present invention is directed to methods for crystallizing macrophage colony stimulating factor (M-CSF) and to a crystalline M-CSF produced thereby. The present invention is also directed to methods for designing and producing M-CSF agonists and antagonists using information derived from the crystallographic structure of M-CSF. The invention is also directed to methods for screening M-CSF agonists and antagonists. In addition, the present invention is directed to an isolated, purified, soluble and functional M-CSF receptor.Type: GrantFiled: May 25, 1995Date of Patent: February 2, 1999Assignee: Chiron CorporationInventors: Jayvardhan Pandit, Jarmila Jancarik, Sung-Hou Kim, Kirston Koths, Robert Halenbeck, Anna Lisa Fear, Eric Taylor, Ralph Yamamoto, Andrew Bohm
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Patent number: 5739409Abstract: Edible fruit, seed and vegetables of transgenic plants modified to produce a sweetening protein such as monellin or thaumatin are useful in preparing food compositions which have enhanced sweetness improved flavor. Expression systems for the genes encoding sweetening proteins compatible with plant systems and designed to enhance the production of these proteins in the edible portions of plants, and methods for producing sweetened fruit, seeds and vegetables are described.Type: GrantFiled: June 7, 1995Date of Patent: April 14, 1998Assignees: The Regents of the University of California, Lucky Biotech Corp.Inventors: Robert Fischer, Sung-Hou Kim, Joong Myung Cho, Lola Penarrubia, James Giovannoni, Rosalind Kim
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Patent number: 5672372Abstract: Single-chain analogs of the naturally occurring two-chain peptide monellin retain the sweetening properties of the natural protein and are stable under conditions which would otherwise destabilize the native peptide. A covalent linkage joins peptides corresponding to portions of the A and B chains of the naturally occurring protein.Type: GrantFiled: June 6, 1995Date of Patent: September 30, 1997Assignees: The Regents of the University of California, Lucky Biotech Corp.Inventors: Sung-Hou Kim, Joong Myung Cho
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Patent number: 5670339Abstract: Single-chain analogs of the naturally occurring two-chain peptide monellin retain the sweetening properties of the natural protein and are stable under conditions which would otherwise destabilize the native peptide. A covalent linkage joins peptides corresponding to portions of the A and B chains of the naturally occurring protein.Type: GrantFiled: June 6, 1995Date of Patent: September 23, 1997Assignees: The Regents of the University of California, Lucky Biotech Corp.Inventors: Sung-Hou Kim, Joong Myung Cho
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Patent number: 5487983Abstract: Single-chain analogs of the naturally occurring two-chain peptide monellin retain the sweetening properties of the natural protein and are stable under conditions which would otherwise destabilize the native peptide. A covalent linkage joins peptides corresponding to portions of the A and B chains of the naturally occurring protein.Type: GrantFiled: November 2, 1993Date of Patent: January 30, 1996Assignees: The Regents of the University of California, Lucky, Ltd.Inventors: Sung-Hou Kim, Joong M. Cho
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Patent number: 5478923Abstract: Single-chain analogs of the naturally occurring two-chain peptide monellin retain the sweetening properties of the natural protein and are stable under conditions which would otherwise destabilize the native peptide. A covalent linkage joins peptides corresponding to portions of the A and B chains of the naturally occurring protein.Type: GrantFiled: March 25, 1994Date of Patent: December 26, 1995Assignees: The Regents of the University of California, Lucky, Ltd.Inventors: Sung-Hou Kim, Joong M. Cho
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Patent number: 5264558Abstract: Single-chain analogs of the naturally occurring two-chain peptide monellin retain the sweetening properties of the natural protein and are stable under conditions which would otherwise destabilize the native peptide. A covalent linkage joins peptides corresponding to portions of the A and B chains of the naturally occurring protein.Type: GrantFiled: March 30, 1990Date of Patent: November 23, 1993Assignees: The Regents of the University of California, Lucky Biotech CorporationInventors: Sung-Hou Kim, Joong M. Cho
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Patent number: 5234834Abstract: Edible fruit, seed and vegetables of transgenic plants modified to produce a sweetening protein such as monellin or thaumatin are useful in preparing food compositions which have enhanced sweetness improved flavor. Expression systems for the genes encoding sweetening proteins compatible with plant systems and designed to enhance the production of these proteins in the edible portions of plants, and methods for producing sweetened fruit, seeds and vegetables are described.Type: GrantFiled: July 24, 1990Date of Patent: August 10, 1993Assignees: The Regents of the University of California, Lucky Biotech Corp.Inventors: Robert Fischer, Sung-Hou Kim, Joong M. Cho, Lola Penarrubia, James Giovannoni, Rosalind Kim