Patents by Inventor Sung Hyen Lee

Sung Hyen Lee has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Antimicrobial activity of chicken NK-2 peptide against apicomplexan protozoa
    Patent number: 8691943
    Abstract: NK-2 synthetic peptide derived from cationic core region of porcine NK-lysin has an antimicrobial and antitumor polypeptide that is considered to play a pivotal role in innate defense immunity. To evaluate the antimicrobial properties of synthetic chicken NK-lysin peptides, we investigated cytolytic activity against apicomplexan parasites like Eimeria sporozoites, Neospora tachyzoites and Cryptosporidum sporozoites. The chicken NK-2 (cNK-2) lytic peptide which corresponds to amino acid residues of porcine NK-2 peptide significantly disrupted Eimeria and Cryptosporidum sporozoites and Neospora tachyzoites. In contrast, no bactericidal activity was observed on E. coli BMH71-18. The cNK-2 lytic peptide is novel antimicrobial agent which can be used to intervene and treat economically costly infections in the animal industry.
    Type: Grant
    Filed: March 24, 2011
    Date of Patent: April 8, 2014
    Assignee: The United States of America, as represented by the Secretary of Agriculture
    Inventors: Hyun Soon Lillehoj, Sung Hyen Lee, Yeong ho Hong
  • Novel Antimicrobial Activity of Chicken NK-2 Peptide Against Apicomplexan Protozoa
    Publication number: 20120245082
    Abstract: NK-2 synthetic peptide derived from cationic core region of porcine NK-lysin has an antimicrobial and antitumor polypeptide that is considered to play a pivotal role in innate defense immunity. To evaluate the antimicrobial properties of synthetic chicken NK-lysin peptides, we investigated cytolytic activity against apicomplexan parasites like Eimeria sporozoites, Neospora tachyzoites and Cryptosporidum sporozoites. The chicken NK-2 (cNK-2) lytic peptide which corresponds to amino acid residues of porcine NK-2 peptide significantly disrupted Eimeria and Cryptosporidum sporozoites and Neospora tachyzoites. In contrast, no bactericidal activity was observed on E. coli BMH71-18. The cNK-2 lytic peptide is novel antimicrobial agent which can be used to intervene and treat economically costly infections in the animal industry.
    Type: Application
    Filed: March 24, 2011
    Publication date: September 27, 2012
    Inventors: Hyun Soon Lillehoj, Sung Hyen Lee, Yeong ho Hong