Patent number: 12168060
Abstract: The present disclosure relates to antibody-drug conjugates (ADCs) wherein one or more active agents are conjugated to an anti-B7-H3 antibody through a linker. The linker may comprise a unit that covalently links active agents to the antibody. The disclosure further relates to monoclonal antibodies and antigen binding fragments, variants, multimeric versions, or bispecifics thereof that specifically bind B7-H3, as well as methods of making and using these anti-B7-H3 antibodies and antigen-binding fragments thereof in a variety of therapeutic, diagnostic and prophylactic indications.
Type:
Grant
Filed:
June 25, 2021
Date of Patent:
December 17, 2024
Assignees:
IntoCell, Inc., Y-Biologics Inc.
Inventors:
Taekyo Park, Sunyoung Kim, Suho Park, Doohwan Jung, Donghoon Seo, Sangkwang Lee, Sanghyeon Yun, Jihyeon Ha, Hyang Sook Lee, Okku Park, Beomseok Seo, Sena Kim, Minah Seol, Jina Song, Sung Ho Woo, Jongun Cho, Jaeho Lee, Hyun Mi Lee, Jae Eun Park, Youngja Song, Eunjin Lee, Hyun Ju Lee, Eun-Young Shim, Yunjung Ko, Minju Lee, Young woo Park, Yosup Rew