Abstract: The present disclosure generally relates to underwater user interfaces.

Abstract: Provided herein are novel CLDN6 binding domains, and anti-CLDN6×anti-CD3 antibodies that include such CLDN6 binding domains. Also provided herein are methods of using such antibodies for the treatment of CLDN6-associated cancers.

Abstract: An ophthalmic device includes an optic including an optic axis and a closed-loop haptic structure coupled to the optic via a frame surrounding the optic, the closed-loop haptic structure including a closed loop extending from first and second attachment points to the frame. The closed loop includes a first hinge and a second hinge. The first hinge has a first section having a first component extending in a first angular direction, a second section having a second component extending in a second angular direction opposite to the first angular direction, and a first connecting section between the first section and the second section. The second hinge has a third section having a third component extending in the second angular direction, a fourth section having a fourth component extending in the first angular direction, the fourth section being connected to the second section to form the closed loop.

Abstract: The present invention is directed to novel heterodimeric antibodies.

Abstract: The present invention provides a vehicle cart transfer system including a plurality of cart transfer devices arranged in parallel, each of which includes a turntable adapted to received a cart placed thereon, a turntable driving unit for rotating the turntable, and a turntable lifting unit for lifting the turntable up and down, wherein the plurality of cart transfer devices rotate the turntables in the opposite direction so that two turntables become close to each other during transfer of the carts. Accordingly, the turntables are rotated in the opposite direction to be adjacent to each other so that the cart loaded on one of the turntables is directly transferred to the other turntable, thus effectively transferring the cart without a conveyor.

Abstract: A 4-aminopyrimidine of the formula (I): ##STR1## wherein A is a bond, C1-4 alkylene or C1-4 oxyalkylene;Y is a bond, C1-4 alkylene, C1-4 alkyleneoxy, C1-4 alkoxyphenylene or phenyl(C1-4)alkylene;Z is a bond or vinylene;R1 is 4-15 membered heterocyclic ring containing one or two nitrogen atom;R2 is (i) 4-15 membered heterocyclic ring containing one or two nitrogen, one or two of oxygen or one sulfur atom,(ii) C4-15 carbocyclic ring,(iii) C1-4 alkoxy,(iv) hydroxy(C1-4 alkoxy) or(v) hydroxy;R3 is (i) 4-15 membered heterocyclic ring containing one or two nitrogen, one oxygen, one sulfur, or one nitrogen and one sulfur atom,(ii) C4-15 carbocyclic ring,(iii) formula:CH2.dbd.CH(X)--whereinX is halogen.(iv) hydrogen.l is 1 or 2.and some compounds are excluded.and acid addition salts thereof, salts thereof; have inhibitory effect on cGMP-PDE, or additionally on TXA2 synthetase.

Abstract: A process for manufacturing a high magnetic flux density grain oriented thin electrical steel sheet having superior magnetic properties and for use on transformers is disclosed. Proper amounts of Sn, Cr, Ni and Mo are added into a high magnetic flux density grain oriented electrical steel sheet in which AlN and MnS are utilized for inhibiting the growth of the primary recrystallization grains. The process results in the production of a high magnetic flux density grain oriented thin electrical steel sheet showing a stabilized recrystallization, a high productivity and a high yield.

Abstract: The compounds of the formula: ##STR1## wherein R.sup.1, Y, A, Z, CyB, R.sup.3, R.sup.4, n and m are described in the specification and claims.and acid addition salts thereof, salts thereof, and hydrates thereof; have inhibitory effect on cGMP-PDE, and additionally on TXA.sub.2 synthetase.

Abstract: The compounds of the formula: ##STR1## wherein R.sup.1, Y, A, R.sup.4, n, Z, CyB, R.sup.3, and m are defined in the specification.

Abstract: A color dry silver (CDS) type color video printer using a color dry silver film on which a color printing is directly achieved, without using a copy sheet. The printer comprises a supply reel for supplying a CDS sheet, an exposure device for exposing the CDS sheet fed from the supply reel thereto to an optical image indicative of a picture to be printed, a capstan roller and a pinch roller for feeding the CDS sheet at a rate corresponding to an exposure rate of the exposure device, a cutting device for cutting the CDS sheet fed thereto at the trailing end of its portion exposed to the optical image, and a thermal development device for heating the cut CDS sheet so as to develop a latent image on the CDS sheet and discharging the CDS sheet through a discharging roller member.

Abstract: An anti-inflammatory composition in which the active ingredient is micronized to form an intimate admixture which can be administered orally.

Abstract: A novel class of pyrrolidin-2-one and piperidin-2-one compounds in which the nitrogen atom is bonded to an oxyphenyl radical having tertiary-alkyl and tri-methylsilyl substituents. The compounds possess anti-inflammatory, immunomodulatory, analgesic and anti-pyretic activity and they may be combined with excipients to provide formulations which are useful in treating arthritis and conditions associated with that disease.

Abstract: A new class of phosphines in which the phosphorous atom is bonded directly to the carbon of an oxazinone: ##STR1## In addition to their anti-inflammatory activity, these phosphines are useful as intermediates in producing compounds where the phosphine is replaced by a benzylidine, compounds which have also been proven useful in the treatment of inflammation and other conditions associated with arthritis.

Abstract: A novel class of pyrrolidin-2-one and piperidin-2-one compounds in which the nitrogen atom is bonded to an oxyphenyl radical haivng tertiary-alkyl and tri-methylsilyl substituents. The compounds posses anti-inflammatory, immunomodulatory, analgesic and anti-pyretic activity and they may be combined with excipients to provide formulations which are useful in treating arthritis and conditions associated with that disease.

Abstract: This invention relates to substituted 5-pyrimidinesulfonamides, pharmaceutically acceptable salts thereof and to processes for synthesis thereof. Other aspects of the invention concern pharmaceutical compositions containing an instant compound as active ingredient and methods of treatment where there is an indicated need for an antihypertensive and/or diuretic agent.

Abstract: A novel class of 5, 6 or 7 member heterocycles which belong to the 3-isoxazolidinone, 2H-1,2-oxazin-3 (4H)-one and 3-isoxazepinone series of compounds and which are substituted at the 4-carbon by a benzylidene radical. The compounds have utility as analgesic agents, immunomodulating agents, anti-inflammatory agents and anti-pyretic agents and they may be combined with excipients to provide formuations which are useful in treating arthritis and conditions generally associated with that disease.

Abstract: This invention relates to substituted 5-pyrimidinesulfonamides, pharmaceutically acceptable salts thereof and to processes for synthesis thereof. Other aspects of the invention concern pharmaceutical compositions containing an instant compound as active ingredient and methods of treatment where there is an indicated need for an antihypertensive and/or diuretic agent.