Abstract: The present invention relates to antibody-drug conjugates (ADCs) wherein a plurality of active agents are conjugated to an antibody through at least one branched linker. The branched linker may comprise a branching unit, and two active agents are coupled to the branching unit through a secondary linker and the branching unit is coupled to the antibody by a primary linker. The active agents may be the same or different. In certain such embodiments, two or more such branched linkers are conjugated to the antibody, e.g., 2-4 branched linkers, which may each be coupled to a different C-terminal cysteine of a heavy or light chain of the antibody. The branched linker may comprise one active agent coupled to the branching unit by a first branch and a second branch that comprises a polyethylene glycol moiety coupled to the branching unit. In certain such embodiments, two or more such branched linkers are conjugated to the antibody, e.g.

Abstract: The present invention relates to a novel naphthyridinone derivative compound, a pharmaceutically acceptable salt thereof, a hydrate thereof, or a stereoisomer thereof, which are each relevant to a compound for inhibiting ENPP1, a composition for inhibiting ENPP1, and a method for inhibiting ENPP1.

Abstract: The present invention relates to a composition for preventing or treating transplantation rejection or a transplantation rejection disease, comprising a novel compound and a calcineurin inhibitor. A co-administration of the present invention 1) reduces the activity of pathogenic Th1 cells or Th17 cells, 2) increases the activity of Treg cells, 3) has an inhibitory effect against side effects, such as tissue damage, occurring in the sole administration thereof, 4) inhibits various pathogenic pathways, 5) inhibits the cell death of inflammatory cells, and 6) increases the activity of mitochondria, in an in vivo or in vitro allogenic model, a transplantation rejection disease model, a skin transplantation model, and a liver-transplanted patient, and thus inhibits transplantation rejection along with mitigating side effects possibly occurring in the administration of a conventional immunosuppressant alone.

Abstract: This patent presents a multidimensional space vector modulation (MDSVM) circuit formed by coupling a half-bridge logic control circuit not directly coupled to electronic components with at least three half-bridge logic control circuits coupled to electronic components. The half-bridge logic control circuit not directly coupled with any electronic components can form a full-bridge circuit with any other half-bridge logic control circuit coupled with electronic components. Therefore, users can further control the voltage difference between both ends of each electronic component separately and then individually control the strength and direction of current flowing through each electronic component and solving the problem of control attributed to the complexity of prior art.

Abstract: A filter holder comprises: a plurality of filter frames disposed such that at least some thereof are adjacent to each other; and a folding member which supports filter frames, from among the plurality of filter frames, adjacent to each other so as to be rotatable with respect to each other. The folding member comprises: a folding part which has a predetermined thickness and is flexible so as to be foldable by means of rotation of the adjacent filter frames adjacent with respect to each other; and a plurality of edge parts which are connected to the respective sides of the folding part with the folding portion therebetween and rotate together with the adjacent filter frames, and wherein when viewed from a cross-section of the folding member, the edge parts may have a greater thickness than the folding part.

Abstract: A method for displaying a page includes: acquiring a plurality of images; extracting features of the plurality of images; generating text based on the features of the plurality of images; and generating the page based on the features of the plurality of images, in which the page includes the plurality of images.

Abstract: The present invention provides a pharmaceutical composition for prevention or treatment of a stress disease and depression, the pharmaceutical composition be safely useable without toxicity and side effects by using an extract of leaves of Vaccinium bracteatum Thunb., which is natural resource of Korea, so that the reduction of manufacturing and production costs and the import substitution and export effects can be expected through the replacement of a raw material for preparation with a plant inhabiting in nature.

Abstract: A pressurizing centrifugal dehydrator for removing moisture according to the present disclosure includes: an inner basket into which slurry is introduced; an outer basket surrounding the inner basket; a blocking barrier disposed in the outer basket; and a gas supplying portion for supplying gas into the inner basket and/or the outer basket, wherein a dehydration product is positioned between an outer circumference of the blocking barrier and an inner side of the outer basket to maintain airtightness of the outer basket.

Abstract: An air filter comprises: a first filter frame in which a plurality of first chambers are formed; a second filter frame in which a plurality of second chambers are formed and which is arranged at the rear of the first filter frame; and a filter material which is accommodated in the plurality of first chambers and the plurality of second chambers to filter air, wherein the first filter frame and the second filter frame are arranged so that, when seen from the front, the center of each of the plurality of second chambers is out of line with the center of each of the plurality of first chambers, in the vertical direction.

Abstract: Provided are a silicon nitride film etching composition, a method of etching a silicon nitride film using the same, and a manufacturing method of a semiconductor device. Specifically, a silicon nitride film may be stably etched with a high selection ratio relative to a silicon oxide film, and when the composition is applied to an etching process at a high temperature and a semiconductor manufacturing process, not only no precipitate occurs but also anomalous growth in which the thickness of the silicon oxide film is rather increased does not occur, thereby minimizing defects and reliability reduction.

Abstract: Provided is a peptide composition for preventing or treating Alzheimer's dementia. A peptide or a salt substituent thereof according to the presently claimed subject matter exhibits effects such as suppression of LPS-mediated cytokine production, suppression of LPS-induced neuroinflammation, amelioration of cognitive impairment, suppression of beta amyloid or tau protein aggregation, and suppression of neuronal loss. The polypeptide or the salt substituent thereof can permeate the blood-brain barrier, and thus, is expected to be usefully used for preventing or treating Alzheimer's dementia.

Abstract: A light-emitting element includes a first semiconductor layer, a light-emitting layer disposed on the first semiconductor layer, a second semiconductor layer disposed on the light-emitting layer, a device electrode layer disposed on the second semiconductor layer, a reflective electrode layer disposed on the device electrode layer, an insulating film surrounding a side surface of the light-emitting layer, a side surface of the second semiconductor layer, and a side surface of the device electrode layer, and a reflective layer surrounding a side surface of the insulating film, wherein the side surface of the device electrode layer is aligned with a side surface of the reflective electrode layer.

Abstract: Disclosed is a device, for matching oral scan data, comprising a first matching unit, a teeth segmentation unit, and a second matching unit. The first matching unit matches a coordinate system of three-dimensional oral scan data to a coordinate system of a three-dimensional oral computed tomography (CT) image by using three-dimensional feature points of the three-dimensional oral scan data and three-dimensional feature points of the three-dimensional oral CT image. The teeth segmentation unit segments teeth from the three-dimensional oral scan data on the basis of the three-dimensional feature points of the three-dimensional oral scan data to generate surface information relating to the segmented teeth. The second matching unit matches the three-dimensional oral scan data and the three-dimensional oral CT image, which have matching coordinate systems, by means of the surface information.

Abstract: Disclosed is a three-dimensional oral scan data matching device including a matching unit, a deep-learning unit, a scanned frame feature determination unit, and a scan data re-matching unit. The matching unit matches a plurality of scanned frames to generate a full mouth image. The deep-learning unit performs deep-learning to detect a feature of the full mouth image. The scanned frame feature determination unit determines a feature of the plurality of scanned frames by utilizing the feature of the full mouth image. The scan data re-matching unit re-matches the plurality of scanned frames on the basis of the feature of the plurality of scanned frames, to reconstruct a three-dimensional oral model.

Abstract: Disclosed is a device for matching three-dimensional intra-oral scan data, the device comprising a computed tomography (CT) image depth map generation unit, a depth map coordinate difference information determination unit, a depth map correction unit, and an intra-oral scan model recovery unit. The CT image depth map generation unit generates a depth map of a CT frame from a CT image by using information about a single scan frame of the scan data. The depth map coordinate difference information determination unit determines depth map coordinate difference information between the depth map of the CT frame and a depth map of the scan frame. The depth map correction unit corrects the depth map of the scan frame on the basis of the depth map coordinate difference information. The intra-oral scan model recovery unit recovers a three-dimensional intra-oral scan model on the basis of the corrected depth map of the scan frame.

Abstract: A multilayer capacitor includes a body including a dielectric layer and a plurality of internal electrodes stacked on each other with the dielectric layer interposed therebetween; and external electrodes disposed externally on the body, and respectively including a first layer connected to the internal electrode and a second layer covering the first layer, wherein the first layer includes a metal particle including an element A, an oxide of an element Z, formed on the metal particle, and an A-Z intermetallic compound phase, and here, the element Z has a higher ionization tendency than the element A.

Abstract: An organic light-emitting diode three-dimensional image display device comprises a first substrate, a cathode formed on the first substrate, an electron injection layer formed on the cathode, an electron transfer layer formed on the electron injection layer, an emission layer formed on the electron transfer layer, a hole transfer layer formed on the emission layer, a hole injection layer formed on the hole transfer layer, an anode formed on the hole injection layer, a wire grid polarizer formed on the anode and composed of a metal thin film pattern formed at a first angle and a method thin film pattern formed at a second angle perpendicular to the first angle, which are alternately arranged, and a second substrate arranged on the wire grid polarizer.

Abstract: A multi-mode 3-dimensional image display apparatus comprises a backlight for emitting light; an image liquid crystal panel for displaying an image using the light emitted from the backlight; and a parallax barrier liquid crystal panel including a first transparent substrate, a first transparent electrode plate disposed on the first transparent substrate and having a front surface formed as a transparent electrode, a first insulation plate disposed on the first transparent electrode plate, a second transparent electrode plate disposed on the first insulation plate and having a transparent electrode material patterned in parallel in a vertical direction, a first alignment layer disposed on the second transparent electrode plate, a liquid crystal layer disposed on the first alignment layer, a second alignment layer disposed on the liquid crystal layer, a third transparent electrode plate disposed on the second alignment layer and having a transparent electrode material patterned in parallel in a vertical directi

Abstract: An organic light-emitting diode three-dimensional image display device comprises a first substrate, a cathode formed on the first substrate, an electron injection layer formed on the cathode, an electron transfer layer formed on the electron injection layer, an emission layer formed on the electron transfer layer, a hole transfer layer formed on the emission layer, a hole injection layer formed on the hole transfer layer, an anode formed on the hole injection layer, a wire grid polarizer formed on the anode and composed of a metal thin film pattern formed at a first angle and a method thin film pattern formed at a second angle perpendicular to the first angle, which are alternately arranged, and a second substrate arranged on the wire grid polarizer.

Abstract: Disclosed herein is an organic light-emitting diode three-dimensional image display device which comprises a first substrate, a cathode formed on the first substrate, an electron injection layer formed on the cathode, an electron transfer layer formed on the electron injection layer, an emission layer formed on the electron transfer layer, a hole transfer layer formed on the emission layer, a hole injection layer formed on the hole transfer layer, an anode formed on the hole injection layer, a wire grid polarizer formed on the anode and composed of a metal thin film pattern formed at a first angle and a method thin film pattern formed at a second angle perpendicular to the first angle, which are alternately arranged, and a second substrate arranged on the wire grid polarizer.