Abstract: Provided is a metastasis-inhibiting composition containing a methylsulfonamide-based derivative compound as an active ingredient. More specifically, the compounds inhibit the activity of chromosome segregation 1-like (CSE1L), and suppress intracellular nuclear transport to inhibit the movement and/or invasion of cancer cells, and thus effectively inhibit metastasis.

Abstract: The present invention relates to a composition for preventing, alleviating or treating inflammatory diseases, comprising, as an active ingredient, an acylhydrazone derivative compound, a stereoisomer thereof or a pharmaceutically acceptable salt thereof. an acylhydrazone derivative compound, a stereoisomer thereof or a pharmaceutically acceptable salt thereof, of the present invention, effectively inhibits inflammatory cytokines and inflammatory signaling pathways, thereby effectively alleviating symptoms of inflammatory diseases such as dermatitis. Therefore, the composition according to the present invention may be effectively used for the prevention, alleviation or treatment of inflammatory diseases.

Abstract: The present invention relates to: an indole derivative, which is a novel cell mitosis inhibitor; a stereoisomer thereof or a pharmaceutically acceptable salt thereof; a use thereof as a therapeutic agent; a composition containing the same and a treatment method using the composition; and a preparation method therefor. According to the present invention, the indole derivative, the stereoisomer thereof or the pharmaceutically acceptable salt thereof, inhibits the tubulin polymerization during mitosis so as to induce apoptosis, and has an excellent anti-cancer effect also in cancer cells having multiple drug resistance.

Abstract: The present invention relates to a composition for preventing, alleviating or treating inflammatory diseases, comprising, as an active ingredient, an acylhydrazone derivative compound, a stereoisomer thereof or a pharmaceutically acceptable salt thereof. an acylhydrazone derivative compound, a stereoisomer thereof or a pharmaceutically acceptable salt thereof, of the present invention, effectively inhibits inflammatory cytokines and inflammatory signaling pathways, thereby effectively alleviating symptoms of inflammatory diseases such as dermatitis. Therefore, the composition according to the present invention may be effectively used for the prevention, alleviation or treatment of inflammatory diseases.

Abstract: The present invention relates to a novel imidazole derivative, a pharmaceutical acceptable salt thereof, and a pharmaceutical composition containing the same as an active ingredient for preventing or treating cancer. The imidazole derivative of the present invention has excellent apoptosis activity, and thus can be useful for treating various hyperproliferative diseases including cancer.

Abstract: A method and apparatus for connecting a manager terminal to an IP PBX system includes receiving a link request signal from the manager terminal via a connection line, switching the link request signal to a central control unit if the link request signal includes appropriate identification information, and activating a predetermined protocol to provide an Internet environment to the manager terminal in response to the link request signal. The connection line between the manager terminal and the IP PBX system is preferably either a single line telephone (SLT) network or an SLT line connected to a public switched telephone network (PSTN). The identification information in the line request signal may be a telephone number from which the manager terminal is communicating or another telephone number. A password authentication procedure may also be implemented to confirm the identify of the manager who sent the link request signal.

Abstract: A method and apparatus for connecting a manager terminal to an IP PBX system includes receiving a link request signal from the manager terminal via a connection line, switching the link request signal to a central control unit if the link request signal includes appropriate identification information, and activating a predetermined protocol to provide an Internet environment to the manager terminal in response to the link request signal. The connection line between the manager terminal and the IP PBX system is preferably either a single line telephone (SLT) network or an SLT line connected to a public switched telephone network (PSTN). The identification information in the line request signal may be a telephone number from which the manager terminal is communicating or another telephone number. A password authentication procedure may also be implemented to confirm the identify of the manager who sent the link request signal.