Patents by Inventor Sung-Min Bae
Sung-Min Bae has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Patent number: 12274750Abstract: A sustained release preparation of a human growth hormone conjugate is disclosed. The sustained release preparation contains a sustained release human growth hormone (hGH) conjugate resulting from conjugation between an immunoglobulin Fc region and a human growth hormone (hGH) as an active peptide; a buffer solution; a nonionic surfactant; and a sugar alcohol. A freeze dried preparation and a liquid preparation including the sustained release human growth hormone conjugate, a production method for the freeze dried preparation, a method of reconstituting the freeze dried preparation, and a kit containing the freeze dried preparation and a reconstituting solution are also disclosed.Type: GrantFiled: December 28, 2020Date of Patent: April 15, 2025Assignee: HANMI PHARM. CO., LTD.Inventors: Hwa Peoung Rim, Hyun Uk Kim, Ho Taek Im, Sang Yun Kim, Hyung Kyu Lim, Sung Min Bae, Se Chang Kwon
-
Patent number: 12139455Abstract: Polyethylene glycol derivatives of the following formula I and uses thereof are disclosed. A method for manufacturing the polyethylene glycol derivatives is also disclosed.Type: GrantFiled: December 20, 2022Date of Patent: November 12, 2024Assignee: HANMI PHARM. CO., LTD.Inventors: Dae Jin Kim, Jong Soo Lee, Sung Min Bae, Se Chang Kwon
-
Publication number: 20230285583Abstract: A liquid formulation of a long-acting conjugate of glucagon, GLP-1, and GIP trigonal agonist, and a method for preparing the liquid formulation are disclosed. The liquid formulation contains 18 nmol/mL to 920 nmol/mL of a long-acting conjugate, a buffering agent in an amount for maintaining the pH of the liquid formulation in the range of 5.0 to 7.0, and 0.5% (w/v) to 10% (w/v) of a sugar alcohol, saccharide, or a combination thereof.Type: ApplicationFiled: May 24, 2021Publication date: September 14, 2023Applicant: HANMI PHARM. CO., LTD.Inventors: Hyung Kyu LIM, Sang Yun KIM, Sung Min BAE
-
Publication number: 20230285584Abstract: A liquid formulation of a long-acting conjugate of GLP-2 and a method for preparing the liquid formulation are disclosed. The liquid formulation contains 18 nmol/mL to 18,630 nmol/mL of a long-acting conjugate, a stabilizer, and a buffering agent in an amount for maintaining the pH of the liquid formulation in the range of 4.5 to 6.5.Type: ApplicationFiled: May 24, 2021Publication date: September 14, 2023Applicant: HANMI PHARM. CO., LTD.Inventors: Sung Hee HONG, Sang Yun KIM, Min Young KIM, Sung Min BAE
-
Publication number: 20230220034Abstract: A method for improving the solubility of a physiologically active protein or peptide compared to that of a physiologically active protein or peptide which is not conjugated to an immunoglobulin Fc fragment is disclosed. The method includes steps of conjugating the physiologically active protein or peptide to an immunoglobulin Fc fragment. Also disclosed is a composition for improving the solubility of a physiologically active protein or peptide, which contains an immunoglobulin Fc fragment. The composition improves the solubility compared to a composition without an immunoglobulin Fc fragment.Type: ApplicationFiled: June 13, 2022Publication date: July 13, 2023Applicant: HANMI PHARM. CO., LTDInventors: Hyung Kyu LIM, Jong Soo LEE, Dae Jin KIM, Sung Min BAE, Sung Youb JUNG, Se Chang KWON
-
Publication number: 20230192800Abstract: A liquid formulation of a long-acting conjugate of glucagon, and a method for preparing the liquid formulation are disclosed. The liquid formulation contains 18 nmol/mL to 936 nmol/mL of a long-acting conjugate, a buffering agent in an amount for maintaining the pH of the liquid formulation in the range of 4.8 to 6.5, and 1.Type: ApplicationFiled: May 24, 2021Publication date: June 22, 2023Applicant: HANMI PHARM. CO., LTD.Inventors: Hyung Kyu LIM, Joo Young DONG, Sang Yun KIM, Sung Min BAE
-
Patent number: 11603346Abstract: The present invention relates to polyethylene glycol derivatives and use thereof.Type: GrantFiled: March 7, 2017Date of Patent: March 14, 2023Assignee: HANMI PHARM. CO., LTD.Inventors: Dae Jin Kim, Jong Soo Lee, Sung Min Bae, Se Chang Kwon
-
Patent number: 11517968Abstract: A deburring tool includes: a body; and a cutting unit provided on an end portion of the body and including a blade part, where a first channel is provided inside the body, and when a fluid supplied from outside of the deburring tool through the first channel is injected into the cutting unit and presses the cutting unit, the cutting unit moves and a degree to which the blade part protrudes outwardly increases.Type: GrantFiled: November 16, 2020Date of Patent: December 6, 2022Assignees: Hyundai Motor Company, Kia Motors CorporationInventors: Sung Min Bae, Jong Youl Park, Jin Youl Kim, Seung Ho Lee, Min Hee Cho
-
Publication number: 20220249615Abstract: Provided is a complex composition, of which positional isomers are minimized by using a N-terminus of an immunoglobulin Fc region as a binding site when the immunoglobulin Fc region is used as a carrier. Also provided are a protein complex which is prepared by N-terminal-specific binding of immunoglobulin Fc region, thereby prolonging blood half-life of the physiologically active polypeptide, maintaining in vivo potency at a high level, and having no risk of immune responses, a preparation method thereof, and a pharmaceutical composition including the same for improving in vivo duration and stability of the physiologically active polypeptide. The protein complex may be usefully applied to the development of long-acting formulations of various physiologically active polypeptide drugs.Type: ApplicationFiled: April 27, 2022Publication date: August 11, 2022Applicant: HANMI PHARM. CO., LTDInventors: Dae Jin KIM, Jong Soo LEE, Young Jin PARK, Sung Hee HONG, Sung Min BAE, Se Chang KWON
-
Publication number: 20220228133Abstract: The present application relates to: a single base substitution protein; a composition comprising same; and a use thereof.Type: ApplicationFiled: May 22, 2020Publication date: July 21, 2022Inventors: Sung Min BAE,, Young Hoon KIM, Jeong Joon LEE
-
Patent number: 11389508Abstract: Provided is a complex composition, of which positional isomers are minimized by using a N-terminus of an immunoglobulin Fc region as a binding site when the immunoglobulin Fc region is used as a carrier. Also provided are a protein complex which is prepared by N-terminal-specific binding of immunoglobulin Fc region, thereby prolonging blood half-life of the physiologically active polypeptide, maintaining in vivo potency at a high level, and having no risk of immune responses, a preparation method thereof, and a pharmaceutical composition including the same for improving in vivo duration and stability of the physiologically active polypeptide. The protein complex prepared by the present invention may be usefully applied to the development of long-acting formulations of various physiologically active polypeptide drugs.Type: GrantFiled: September 26, 2016Date of Patent: July 19, 2022Assignee: HANMI PHARM. CO., LTD.Inventors: Dae Jin Kim, Jong Soo Lee, Young Jin Park, Sung Hee Hong, Sung Min Bae, Se Chang Kwon
-
Patent number: 11207383Abstract: Provided is a complex composition, of which positional isomers are minimized by using a N-terminus of an immunoglobulin Fc region as a binding site when the immunoglobulin Fc region is used as a carrier. Also provided are a protein complex which is prepared by N-terminal-specific binding of immunoglobulin Fc region, thereby prolonging blood half-life of the physiologically active polypeptide, maintaining in vivo potency at a high level, and having no risk of immune responses, a preparation method thereof, and a pharmaceutical composition including the same for improving in vivo duration and stability of the physiologically active polypeptide. The protein complex may be usefully applied to the development of long-acting formulations of various physiologically active polypeptide drugs.Type: GrantFiled: October 28, 2019Date of Patent: December 28, 2021Assignee: HANMI PHARM. CO., LTDInventors: Dae Jin Kim, Jong Soo Lee, Young Jin Park, Sung Hee Hong, Sung Min Bae, Se Chang Kwon
-
Publication number: 20210394282Abstract: A deburring tool includes: a body; and a cutting unit provided on an end portion of the body and including a blade part, where a first channel is provided inside the body, and when a fluid supplied from outside of the deburring tool through the first channel is injected into the cutting unit and presses the cutting unit, the cutting unit moves and a degree to which the blade part protrudes outwardly increases.Type: ApplicationFiled: November 16, 2020Publication date: December 23, 2021Inventors: Sung Min Bae, Jong Youl Park, Jin Youl Kim, Seung Ho Lee, Min Hee Cho
-
Patent number: 11168109Abstract: Disclosed is a method for the preparation of a complex in which a physiologically active polypeptide is covalently bonded to an immunoglobulin constant region via a non-peptidyl linker. The method is characterized by the employment of a reducing agent, by which conventional problems of low production yield and modification of the polypeptide can be overcome. The physiologically active polypeptide-non-peptidyl polymer-immunoglobulin constant region complex can be produced with high purity and yield as well as at low cost. Thus, the method is industrially useful. Moreover, by exhibiting a prolonged action profile, the physiologically active polypeptide-non-peptidyl polymer-immunoglobulin constant region complex can be effectively used for developing long-acting formulations of physiologically active polypeptides which have improved drug compliance.Type: GrantFiled: March 8, 2013Date of Patent: November 9, 2021Assignee: HANMI SCIENCE CO., LTD.Inventors: Myung Hyun Jang, Min Young Kim, Jong-soo Lee, Dae Jin Kim, Sung Min Bae, Se Chang Kwon
-
Patent number: 11135271Abstract: The present invention relates to a novel glucagon derivative peptide, and a composition for preventing or treating hypoglycemia containing the novel glucagon derivative peptide as an active ingredient. The glucagon derivative according to the present invention has improved physical properties due to the change in isoelectric point (pI) while being capable of maintaining an activity on glucagon receptors, and thus can improve patient compliance when used as a hypoglycemic agent, and is also suitable for administration in combination with other anti-obesity agents. Accordingly, the glucagon derivative according to the present invention can be effectively used for the prevention and treatment of hypoglycemia and obesity.Type: GrantFiled: December 30, 2015Date of Patent: October 5, 2021Assignee: HANMI PHARM. CO., LTD.Inventors: Jung Kuk Kim, Jong Min Lee, Sang Yun Kim, Sung Min Bae, Sung Youb Jung, Se Chang Kwon
-
Patent number: 11071785Abstract: The present invention relates to an albumin-free liquid formulation comprising a long-lasting oxyntomodulin conjugate in which an oxyntomodulin peptide comprising a derivative, variant, precursor or fragment of oxyntomodulin is linked to an immunoglobulin Fc region, which can increase the duration of physiological activity of the long-lasting oxyntomodulin conjugate and maintain the in vivo stability thereof for an extended period of time, as compared to native oxyntomodulin, as well as a method for preparing the liquid formulation. The liquid formulation comprises a buffer, a sugar alcohol and a nonionic surfactant and does not contain a human serum albumin and factors that are potentially harmful to the human body, and thus is not susceptible to viral infection.Type: GrantFiled: March 18, 2019Date of Patent: July 27, 2021Assignee: HANMI PHARM. CO., LTD.Inventors: Hyun Uk Kim, Hyung Kyu Lim, Myung Hyun Jang, Sang Yun Kim, Sung Min Bae, Se Chang Kwon
-
Publication number: 20210138070Abstract: A sustained release preparation of a human growth hormone conjugate is disclosed. The sustained release preparation contains a sustained release human growth hormone (hGH) conjugate resulting from conjugation between an immunoglobulin Fc region and a human growth hormone (hGH) as an active peptide; a buffer solution; a nonionic surfactant; and a sugar alcohol. A freeze dried preparation and a liquid preparation including the sustained release human growth hormone conjugate, a production method for the freeze dried preparation, a method of reconstituting the freeze dried preparation, and a kit containing the freeze dried preparation and a reconstituting solution are also disclosed.Type: ApplicationFiled: December 28, 2020Publication date: May 13, 2021Applicant: HANMI PHARM. CO., LTD.Inventors: Hwa Peoung RIM, Hyun Uk KIM, Ho Taek IM, Sang Yun KIM, Hyung Kyu LIM, Sung Min BAE, Se Chang KWON
-
Patent number: 10987424Abstract: The present invention relates to a liquid formulation of long-acting insulin conjugate, comprising a pharmaceutically effective amount of a long-acting insulin conjugate, wherein a physiologically active peptide, which is an insulin, is linked to an immunoglobulin Fc region; and an albumin-free stabilizer, wherein the stabilizer comprises a buffer, a sugar alcohol, a non-ionic surfactant, and an isotonic agent, and a method for preparing the formulation. For preventing microbial contamination in multiple uses, a preservative can be added to the formulation. The liquid formulation of the present invention does not comprise a human serum albumin and potentially hazardous factors to body, and thus it has excellent storage stability for insulin conjugate without a risk of viral infection.Type: GrantFiled: July 25, 2013Date of Patent: April 27, 2021Assignee: HANMI PHARM. CO., LTD.Inventors: Hyung Kyu Lim, Hyun Uk Kim, Sung Hee Hong, Min Young Kim, Sung Min Bae, Se Chang Kwon
-
Patent number: 10987425Abstract: The present invention relates to a sustained type human growth hormone conjugate preparation comprising: a sustained type human growth hormone (hGH) conjugate resulting from conjugation between the immunoglobulin Fc region and a human growth hormone (hGH) constituting a bioactive peptide; a buffer solution; a nonionic surfactant; and a sugar alcohol. More specifically, the present invention relates to a sustained type human growth hormone conjugate freeze dried preparation and liquid preparation, to a production method for the freeze dried preparation, to a method of reconstituting the freeze dried preparation, and to a kit comprising the freeze dried preparation and a reconstituting solution.Type: GrantFiled: September 26, 2014Date of Patent: April 27, 2021Assignee: HANMI PHARM. CO., LTD.Inventors: Hwa Peoung Rim, Hyun Uk Kim, Ho Taek Im, Sang Yun Kim, Hyung Kyu Lim, Sung Min Bae, Se Chang Kwon
-
Patent number: 10881715Abstract: The present invention relates to a novel glucagon derivative peptide, and a composition for preventing or treating hypoglycemia containing the novel glucagon derivative peptide as an active ingredient. The glucagon derivative according to the present invention has improved physical properties due to the change in isoelectric point (pI) while being capable of maintaining an activity on glucagon receptors, and thus can improve patient compliance when used as a hypoglycemic agent, and is also suitable for administration in combination with other anti-obesity agents. Accordingly, the glucagon derivative according to the present invention can be effectively used for the prevention and treatment of hypoglycemia and obesity.Type: GrantFiled: December 30, 2015Date of Patent: January 5, 2021Assignee: HANMI PHARM. CO., LTD.Inventors: Jung Kuk Kim, Jong Min Lee, Sang Yun Kim, Sung Min Bae, Sung Youb Jung, Se Chang Kwon