Abstract: The present invention provides a bispecific epitope binding protein comprising an anti-4-1BB agonist antibody and a PD-1 protein or a fragment thereof that binds to PD-L1 with high affinity. The bispecific epitope binding protein simultaneously and independently binds to 4-1BB and PD-L1, which engage 4-1BB upregulated T cells, especially effector CD8+ T cells, with tumor cells expressing PD-L1. These interactions induce strong activation of the cytotoxic activity of anti-tumor effector CD8+ T cells by both blocking PD-1/PD-L1-mediated inhibitory signaling and activating 4-1BB-mediated costimulatory signaling in mouse models. This bispecific epitope binding protein has a much stronger oncolytic effect compared to each component alone.

Abstract: An apparatus for estimating biological information of a user may include a light source configured to emit light to an object of the user; an image sensor comprising a pixel array, and configured to acquire successive image frames by detecting light scattered or reflected from the object of the user; and a processor configured to: select a predetermined number of pixel-rows from among pixel-rows of the image sensor, detect signal intensities in the predetermined number of pixel-rows for each image frame of the successive image frames, correct the signal intensities, combine the signal intensities for each image frame of the successive image frames based on correcting the signal intensities, acquire a photoplethysmogram (PPG) signal based on combining the signal intensities, and estimate the biological information of the user based on the PPG signal.

Abstract: An apparatus for predicting hypoglycemia according to an exemplary embodiment of the present disclosure is an apparatus for predicting hypoglycemia, which predicts the occurrence of postprandial hypoglycemia using blood glucose-related information, wherein the blood glucose-related information includes a blood glucose level at a reference time, a blood glucose change rate over a duration from a mealtime to a postprandial peak blood glucose level time, a blood glucose change rate over a duration from the postprandial peak blood glucose level time to the reference time, and a blood glucose change rate at the reference time.

Abstract: A method of determining a continuous drug dose using reinforcement learning and a pharmacokinetic-pharmacodynamic model according to an embodiment of the present invention includes, measuring or estimating a patient's pharmacokinetic-pharmacodynamic model; training a reinforcement learning algorithm using drug infusion data and patient state data based on the pharmacokinetic-pharmacodynamic model; and automatically determining a continuous drug dose by the trained reinforcement learning algorithm.

Abstract: A method includes forming hard mask patterns by depositing a support mask layer, a polycrystalline silicon layer, and a hard mask layer on a substrate and etching the hard mask layer, forming pre-polycrystalline silicon patterns by etching the polycrystalline silicon layer using the hard mask patterns as an etch mask, oxidizing side surfaces of the pre-polycrystalline silicon patterns to form polycrystalline silicon patterns and a silicon oxide layer, forming spacer patterns covering sides of the silicon oxide layer, forming a sacrificial layer on a top surface of the support mask layer to cover the silicon oxide layer and the spacer patterns, etching the sacrificial layer and the silicon oxide layer, forming support mask patterns by etching the support mask layer using the polycrystalline silicon patterns and the spacer patterns as an etch mask, and forming activation pins by etching the substrate using the support mask patterns as an etch mask.

Abstract: An apparatus for controlling a lane change of a vehicle includes: a sensor to sense an external vehicle, an input device to receive a lane change command from a driver of the vehicle, and a control circuit to be electrically connected with the sensor and the input device. The control circuit may receive the lane change command using the input device, calculate a minimum operation speed for lane change control, and determine whether to accelerate the vehicle based on a distance between a preceding vehicle which is traveling on the same lane as the vehicle and the vehicle, when a driving speed of the vehicle is lower than the minimum operation speed when receiving the lane change command.

Abstract: An apparatus for providing a safety strategy in a vehicle is provided. The apparatus includes a sensor configured to obtain information about a driver of the vehicle, an output device configured to output a notification to the driver, and a control circuit configured to be electrically connected with the sensor and the output device. The control circuit is configured to recognize a state of the driver based on the information obtained by the sensor, set a route toward a safety zone, when the state of the driver meets a specified condition, and control the vehicle to change a lane where the vehicle is traveling to a lane adjacent to the safety zone.

Abstract: An apparatus for controlling a lane change of a vehicle includes: a sensor to sense an external vehicle, an input device to receive a lane change command from a driver of the vehicle, and a control circuit to be electrically connected with the sensor and the input device. The control circuit may receive the lane change command using the input device, calculate a minimum operation speed for lane change control, and determine whether to accelerate the vehicle based on a distance between a preceding vehicle which is traveling on the same lane as the vehicle and the vehicle, when a driving speed of the vehicle is lower than the minimum operation speed when receiving the lane change command.

Abstract: Implantable apparatuses are provided, where the implantable apparatus includes a first electrode, a second electrode, an electrode signal transceiver connected to the first electrode and the second electrode, an antenna, a wireless power receiver connected to the antenna, and a conductor case configured to protect the electrode signal transceiver and the wireless power receiver. The antenna be spaced apart from the conductor case and encloses the conductor case, and a plane in which the antenna is disposed is at a same level or at a higher level than a top surface of the conductor case.

Abstract: An apparatus for controlling a lane change of a vehicle includes: a sensor to sense an external vehicle, an input device to receive a lane change command from a driver of the vehicle, and a control circuit to be electrically connected with the sensor and the input device. The control circuit may receive the lane change command using the input device, calculate a minimum operation speed for lane change control, and determine whether to accelerate the vehicle based on a distance between a preceding vehicle which is traveling on the same lane as the vehicle and the vehicle, when a driving speed of the vehicle is lower than the minimum operation speed when receiving the lane change command.

Abstract: A small-sized motor apparatus for a vehicle, includes: a frame; a drive shaft mounted to the frame, a driven shaft to rotate dependently on the drive shaft, the driven shaft including a second worm gear; a cover coupled to the frame; a plate-shaped washer member; and a gap spring member preventing an axial movement of the driven shaft, the gap spring member being assembled in a radial direction of the driven shaft and installed such that one side of the gap spring member is contact-supported by the plate-shaped washer member and the other side of the gap spring member is supported by the frame, wherein the frame includes a slide groove that accommodates both ends of the gap spring member and the plate-shaped washer member and restricts the gap spring member from moving in an axial direction of the driven shaft.

Abstract: An apparatus for controlling a lane change of a vehicle includes: a sensor to sense an external vehicle, an input device to receive a lane change command from a driver of the vehicle, and a control circuit to be electrically connected with the sensor and the input device. The control circuit may receive the lane change command using the input device, calculate a minimum operation speed for lane change control, and determine whether to accelerate the vehicle based on a distance between a preceding vehicle which is traveling on the same lane as the vehicle and the vehicle, when a driving speed of the vehicle is lower than the minimum operation speed when receiving the lane change command.

Abstract: The present invention relates to a cosmetic composition for whitening comprising a Caragana sinica root extract, and more specifically relates to a cosmetic composition having an outstanding skin-whitening effect, the composition comprising a Caragana sinica root extract, a fraction thereof or ?-viniferin isolated therefrom. In the present invention, the Caragana sinica root extract, fraction thereof or ?-viniferin isolated therefrom inhibits tyrosinase activity and suppresses melanin production and is therefore effective in skin whitening.

Abstract: An apparatus for controlling a lane change of a vehicle includes: a sensor to sense an external vehicle, an input device to receive a lane change command from a driver of the vehicle, and a control circuit to be electrically connected with the sensor and the input device. The control circuit may receive the lane change command using the input device, calculate a minimum operation speed for lane change control, and determine whether to accelerate the vehicle based on a distance between a preceding vehicle which is traveling on the same lane as the vehicle and the vehicle, when a driving speed of the vehicle is lower than the minimum operation speed when receiving the lane change command.

Abstract: Provided is a catheter including a shaft having a distal end and a loop disposed near the distal end and configured to curl around a tissue and receive, via the shaft, energy to denervate at least a portion of the tissue. The loop includes: a first film capable of bending to curl around the tissue; a plurality of electrodes disposed on the first film and arranged in parallel to each other with a predetermined distance; a sensor disposed at a position corresponding to a position between the plurality of electrodes.

Abstract: An apparatus for controlling a lane change of a vehicle includes: a sensor to sense an external vehicle, an input device to receive a lane change command from a driver of the vehicle, and a control circuit to be electrically connected with the sensor and the input device. The control circuit may receive the lane change command using the input device, calculate a minimum operation speed for lane change control, and determine whether to accelerate the vehicle based on a distance between a preceding vehicle which is traveling on the same lane as the vehicle and the vehicle, when a driving speed of the vehicle is lower than the minimum operation speed when receiving the lane change command.

Abstract: A lithium secondary battery is provided which includes a cylindrical jelly roll in which an electrode assembly having a stacked structure including a positive electrode is wound cylindrically, wherein a semi-cylindrical first winding core and second winding core are spaced apart from each other by a predetermined interval, the positive electrode includes a non-coated portion sheet having a positive electrode tab fused thereto and a coated portion sheet, and the non-coated portion sheet and the coated portion sheet are attached by a tape to provide the positive electrode, one end of the positive electrode is positioned at the core portion of the cylindrical jelly roll, and a portion of the positive electrode having the tape is positioned around a circumference of the winding core member such that it avoids a portion where the first winding core is spaced apart from the second winding core by the predetermined interval.

Abstract: Gamma-butyrolactone (“GBL”) and Gamma-hydroxybutyrate (“GHB”) having a unique carbon footprint as defined by the percent modern carbon (pmc) are described herein. The percent modern carbon can be controlled by varying the amounts of biobased, renewable starting materials and petroleum-based starting materials to prepare GBL or GHB having a defined pmc or by preparing mixtures of GBL or GHB prepared from biobased renewable starting materials and GBL or GHB prepared from petroleum-based starting materials.

Abstract: Provided is a catheter including a shaft having a distal end removably connected to a distal portion and a proximal end coupled to a holder; a loop disposed near the distal end and configured to curl around a tissue and receive, via the shaft, energy to denervate at least a portion of the tissue; a loop control disposed on a butt of the holder and configured to deliver a mechanical bending force to the loop. The loop includes at least a portion made of a shape-memory alloy whose shape changes at a critical temperature. In a first mode, the loop is configured to curl around the tissue at a first curvature at a temperature below the critical temperature by the mechanical bending force. In a second mode, the loop is configured to curl around the tissue at a second curvature at a temperature above the critical temperature.

Abstract: Provided is a cosmetic composition for skin moisturization containing a hydrolyzate extract obtained by adding a protease to the fruit of Cicer arietinum, a Rhododendron chrysanthum leaf extract and a Tricholoma matsutake extract. The cosmetic composition exhibits excellent effects on cell moisturization, intercellular moisturization and skin-barrier moisturization. In addition, the cosmetic composition is harmless to the human body and has excellent stability because it uses natural substances.