Abstract: The present invention relates to a method for extending a half-life of a protein, comprising substituting one lysine residue in each of the amino acid sequences in two proteins, or to a protein having an extended half-life. The protein in which lysine residues have been substituted according to the present invention remains in the body for an extended period of time, and exhibits excellent treatment results. In addition, two proteins can be produced and provided in a single production process.

Abstract: The present invention relates to a method for prolonging half-life of a protein or a (poly)peptide by replacing one or more amino acid residues of the protein. Further, the present invention is about the protein having a prolonged half-life prepared by the method above.

Abstract: The present invention relates to a method for prolonging half-life of a protein or a (poly)peptide by replacing one or more amino acid residues of the protein. Further, the present invention is about the protein having a prolonged half-life prepared by the method above.

Abstract: The present invention relates to a method for prolonging half-life of a protein or a (poly)peptide by replacing one or more amino acid residues of the protein. Further, the present invention is about the protein having a prolonged half-life prepared by the method above.

Abstract: The present invention relates to a method for prolonging half-life of a protein or a (poly)peptide by replacing one or more amino acid residues of the protein. Further, the present invention is about the protein having a prolonged half-life prepared by the method above.

Abstract: The present invention relates to a method for prolonging half-life of a protein or a (poly)peptide by replacing one or more amino acid residues of the protein. Further, the present invention is about the protein having a prolonged half-life prepared by the method above.

Abstract: The present invention relates to a method for prolonging half-life of a protein or a (poly)peptide by replacing one or more amino acid residues of the protein. Further, the present invention is about the protein having a prolonged half-life prepared by the method above.

Abstract: The present invention relates to a method for prolonging half-life of a protein or a (poly)peptide by replacing one or more amino acid residues of the protein. Further, the present invention is about the protein having a prolonged half-life prepared by the method above.

Abstract: The present disclosure provides a heavy-duty tire including: a tread part configured to come into contact with a road surface; a steel belt part including one or more steel belts formed inside the tread part; and a reinforcing belt part inserted between the one or more steel belts or between the tread part and the steel belt part, in which the reinforcing belt part is manufactured as a rolling product made by winding a steel cord in a circumferential direction of the tire.

Abstract: The present invention relates to a method for prolonging the half-life of a protein, the method comprising substituting at least one lysine residue present in the amino acid sequence of the protein, and to a protein having an extended half-life. The protein of the present invention, in which the lysine residue has been substituted, remains in the human body for a long time and exhibits an excellent therapeutic effect. The protein of the present invention includes EGF, PDGFA and PDGFB, GM-CSF, FSH-alpha and FSH-beta, and ANGPT-1.

Abstract: The present invention relates to a method for prolonging half-life of a protein or a (poly)peptide by replacing one or more amino acid residues of the protein. Further, the present invention is about the protein having a prolonged half-life prepared by the method above.

Abstract: An ultra super single tire for heavy duty includes a tread that contacts the road surface; a carcass that constitutes the skeleton of the tire; and a belt layer that is disposed between the tread and the carcass, in which the belt layer is composed of a first belt to a fourth belt that are laminated sequentially from the carcass toward the tread, the first belt includes an extender belt, and the second belt is a wide spiral coil belt. Thus, an excessive increase in weight, the occurrence of excessive heat generation, and deterioration of durability can be prevented, while enhancing the ground contact length at the ground contacting center, and further enhancing the durability at belt layer edges.