Abstract: A novel mutation in the SCN5A gene is associated with loss of cardiac sodium channel function. Analysis of the novel mutation provides an early diagnosis of subjects with cardiac diseases or disorders caused by loss of cardiac sodium channel function, particularly Brugada syndrome. Diagnostic methods include analyzing the sequences of the SCN5A gene or protein of an individual to be tested and comparing them with the sequences of the native, nonvariant SCN5A gene or protein. Pre-symptomatic diagnosis of these syndromes will enable practitioners to treat these disorders using existing medical therapy, e.g., using sodium channel blockers or through electrical stimulation.

Abstract: A non-impact printing method wherein pulsed light is transmitted through a mask containing enlarged characters. The characters are optically reduced and are focused on a document in back of a heat-sensitive or thermal magnetic ink ribbon. Heat energy projected by the pulsed light causes ink transfer from the ribbon onto the paper.