Patents by Inventor Sung-Su Lim

Sung-Su Lim has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11421237
    Abstract: The present disclosure relates to a vector pair for screening TDP-43 (TAR DNA-binding protein 43 or TransActive Response DNA-binding protein 43) oligomer formation, a cell line transfected with the vector pair, and a method of monitoring TDP-43 oligomer formation using the cell line. More specifically, the vector pair includes: a first vector including a first TDP-43 gene and a first fluorescence protein gene; and a second vector including a second TDP-43 gene and a second fluorescence protein gene, wherein a protein expressed from the first fluorescence protein gene and a protein expressed from the second fluorescence protein gene bind to each other to display fluorescence, by association between a protein expressed from the first TDP-43 gene and a protein expressed from the second TDP-43 gene. The vector pair is effective in that it makes it possible to monitor TDP-43 oligomer formation in living cells.
    Type: Grant
    Filed: April 23, 2020
    Date of Patent: August 23, 2022
    Assignee: Korea Institute of Science and Technology
    Inventors: Sung Su Lim, Seul Gi Shin, Yun Kyung Kim
  • Publication number: 20210255203
    Abstract: Disclosed are a compound with near-infrared fluorescence that selectively binds to tau aggregates, a method for preparing the same, a tau-targeting near-infrared fluorescent probe including the compound, a composition for detecting a tau fiber protein containing the near-infrared fluorescent probe as an active ingredient, and the use of the composition for the diagnosis of tauopathy. In particular, the compound does not bind to an amyloid beta protein and has high selectivity to a tau aggregate, specifically reported as an etiology of the initial state of tauopathy, thus being useful as a near-infrared fluorescent detector for detecting a tau fiber protein for early diagnosis of a tauopathy including Alzheimer's disease.
    Type: Application
    Filed: September 15, 2020
    Publication date: August 19, 2021
    Inventors: Ghil Soo NAM, Hyun Ah CHOO, Ahmed A. Elbatrawy, Gyo Chang KEUM, Yun Kyung KIM, Sung Su LIM, Jae Kyun LEE, Eun Kyoung BANG
  • Publication number: 20200340001
    Abstract: The present disclosure relates to a vector pair for screening TDP-43 (TAR DNA-binding protein 43 or TransActive Response DNA-binding protein 43) oligomer formation, a cell line transfected with the vector pair, and a method of monitoring TDP-43 oligomer formation using the cell line. More specifically, the vector pair includes: a first vector including a first TDP-43 gene and a first fluorescence protein gene; and a second vector including a second TDP-43 gene and a second fluorescence protein gene, wherein a protein expressed from the first fluorescence protein gene and a protein expressed from the second fluorescence protein gene bind to each other to display fluorescence, by association between a protein expressed from the first TDP-43 gene and a protein expressed from the second TDP-43 gene. The vector pair is effective in that it makes it possible to monitor TDP-43 oligomer formation in living cells.
    Type: Application
    Filed: April 23, 2020
    Publication date: October 29, 2020
    Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY
    Inventors: Sung Su LIM, Seul Gi SHIN, Yun Kyung KIM
  • Patent number: 10544427
    Abstract: Disclosed is a vector pair for screening tau oligomer formation, a mouse embryo introduced with the vector pair, a transgenic model mouse of neurological disease, obtained from the mouse embryo, and a method of screening a tau oligomer formation inhibitor candidate using the transgenic model mouse. More specifically, the present invention provides vector pair for screening tau oligomer formation, comprising: a first vector comprising a first tau gene, a first fluorescence protein gene and a first neuron-specific promoter; and a second vector comprising a second tau gene, a second fluorescence protein gene and a second neuron-specific promoter, wherein a protein expressed from the first fluorescence protein gene and a protein expressed from the second fluorescence protein gene bind to each other to display fluorescence, by association between a protein expressed from the first tau gene and a protein expressed from the second tau gene.
    Type: Grant
    Filed: September 20, 2017
    Date of Patent: January 28, 2020
    Assignee: Korea Institute of Science and Technology
    Inventors: Do Hee Kim, Seul Gi Shin, Sung Su Lim, Ae Nim Pae, Dong Jin Kim, Yun Kyung Kim
  • Patent number: 9962384
    Abstract: Disclosed is a levosimendan compound, an optically active isomer thereof, or a pharmaceutically acceptable salt thereof, which is used for the prevention and/or treatment of diseases caused by tau aggregation or phosphorylation, such as neurodegenerative diseases (e.g., Alzheimer disease). In accordance with yet another aspect of the present invention, there is provided a health functional food for preventing or treating tau aggregation-related diseases, containing a levosimendan compound or a pharmaceutically acceptable salt, stereoisomer or solvate thereof.
    Type: Grant
    Filed: September 7, 2017
    Date of Patent: May 8, 2018
    Assignee: Korea Institute of Science and Technology
    Inventors: Yun Kyung Kim, Sung Su Lim, Do Hee Kim, Md. Mamunul Haque, Seul Gi Shin, Ha Eun Lee, Tae Hun Kim, Sang Min Lim, Ae Nim Pae
  • Publication number: 20180119169
    Abstract: Disclosed is a vector pair for screening tau oligomer formation, a mouse embryo introduced with the vector pair, a transgenic model mouse of neurological disease, obtained from the mouse embryo, and a method of screening a tau oligomer formation inhibitor candidate using the transgenic model mouse. More specifically, the present invention provides vector pair for screening tau oligomer formation, comprising: a first vector comprising a first tau gene, a first fluorescence protein gene and a first neuron-specific promoter; and a second vector comprising a second tau gene, a second fluorescence protein gene and a second neuron-specific promoter, wherein a protein expressed from the first fluorescence protein gene and a protein expressed from the second fluorescence protein gene bind to each other to display fluorescence, by association between a protein expressed from the first tau gene and a protein expressed from the second tau gene.
    Type: Application
    Filed: September 20, 2017
    Publication date: May 3, 2018
    Applicant: Korea Institute of Science and Technology
    Inventors: Do Hee KIM, Seul Gi Shin, Sung Su Lim, Ae Nim Pae, Dong Jin Kim, Yun Kyung Kim
  • Patent number: 5869477
    Abstract: A .beta.-methylcarbapenem compound of formula (I), a salt or an ester thereof, a process for the preparation thereof and a anti-bacterial composition containing same: ##STR1## wherein: R.sup.1 is a C.sub.1-6 alkyl, C.sub.2-6 alkenyl, cycloalkyl, aryl or heterocyclic aryl group.
    Type: Grant
    Filed: December 4, 1996
    Date of Patent: February 9, 1999
    Assignee: Korea Research Institute of Chemistry Technology
    Inventors: Cheol-Hae Lee, Dong-Ha Lee, Kyung-Sook Kim, Jae-Hak Kim, Young-Sook Kim, Yu-Sung Jun, Sung-Su Lim, Eun-Mi Bae, Bong-Jin Kim