Abstract: The polymeric carrier for delivering nucleic acid material to a cell is provided herein. The polymeric carrier can include a dendrimer group having 2 to 8 termini, each of the termini having an arginine-grafted bioreducible polymer attached thereto. In one embodiment, only a portion of the termini can have an arginine-grafted bioreducible polymer attached thereto.

Abstract: Improved poly(amido ethylenimine) copolymers for gene delivery are disclosed. One illustrative embodiment includes polyethylene glycol (PEG) covalently bonded to a branched poly(triethyenetetramine/cystamine bisacrylamide) copolymer (poly(TETA/CBA)). The polyethylene glycol can be linear or branched. Another illustrative embodiment includes an RGD peptide covalently bonded to the poly(TETA/CBA)-PEG conjugate. Still another illustrative embodiment includes a method of using these compositions for transfecting a cell with a nucleic acid.

Abstract: The treatment device for hemiplegia comprises a robot which is putted on the hemiplegic side of the body of a subject; a motion measurement unit for measuring the motion of the healthy side of the body of the subject; and a control which is connected with the robot and the motion measurement unit, wherein the control unit is configured to receive the healthy side's motion measured by the motion measurement unit and to control the robot, whereby the hemiplegic side having the robot put thereon moves in accordance with the motion of the healthy side of the body.

Abstract: Provided is a method of online advertising using a free advertising website, including: a first step of enabling the free advertising website to join as a member using a user terminal; a second step of accessing the free advertising website, checking the advertisement posted on the first page of the website, and executing either an advertisement posting category or an advertisement search category using the user terminal; a third step of, if the advertisement posting category is selected, being activated as an advertisement provider, posting an advertisement, and paying points for the posted advertisement and questionnaire on the advertisement; and a fourth step of, if the advertisement search category is selected, being activated as an advertisement viewer, searching advertisements, executing and viewing the found advertisement, answering the questionnaire on the advertisement, and getting points for viewing the advertisement and answering the questionnaire.

Abstract: The present invention discloses a laser emission system comprising a laser emission device for irradiation a laser to an area of a targeted object; a monitoring device; a display unit for displaying an image captured by the monitoring device; and a control unit connected to the monitoring device and the display unit. Here, the control unit receives the information on a movement direction and a moving distance of the laser emission device and distinguishes between an area emitted with a laser by the laser emission device and an area which is not emitted with a laser, and then displays them on the display unit. Regardless of the perceived skill of the operator, the present invention prevents the irradiation of the area from being omitted and prevents the area from being excessively or insufficiently emitted in the laser treatment.

Abstract: Polyplex formulations were prepared using p(TETA/CBA), its PEGylated analog, p(TETA/CBA)-g-PEG2k, and mixtures of the two species at 10/90 and 50/50 wt %, respectively. Increasing PEG wt % inhibited polyplex formation. This work demonstrates the feasibility of preparing homogenous polyplexes by altering the PEG wt % using a mixture of p(TETA/CBA) and p(TETA/CBA)-g-PEG2k products. Further, a single-step method of making p(TETA/CBA)-g-PEG2k is disclosed.

Abstract: A biologic ventricular assist device that also has the capability to capture, grow, and administer stem cells to regenerate and restore damaged myocardium in the heart. The device works in conjunction with a traditional ventricular assist device and possesses an additional external path or tube that is in-line with the path of the ventricular assist device. The external path allows for the administration of stem cells, genes, genetically modified cells or other therapeutic biologic or pharmacologic agents, as well as leading to a stem cell collecting accessory that captures circulating stem cells. The stem cell collecting accessory is also associated with a chamber for culturing the captured stem cells.

Abstract: A pellicle frame, including aluminum, aluminum oxide, and a transition metal.

Abstract: A biologic ventricular assist device that also has the capability to capture, grow, and administer stem cells to regenerate and restore damaged myocardium in the heart. The device works in conjunction with a traditional ventricular assist device and possesses an additional external path or tube that is in-line with the path of the ventricular assist device. The external path allows for the administration of stem cells, genes, genetically modified cells or other therapeutic biologic or pharmacologic agents, as well as leading to a stem cell collecting accessory (14) that captures circulating stem cells. The stem cell collecting accessory is also associated with a chamber (39) for culturing the captured stem cells.

Abstract: An arginine-grafted bioreducible poly(disulfide amine) (“ABP”) as a reagent for efficient and nontoxic gene delivery is described. ABP forms positively charged nano-particles of less than 200 nm with plasmid DNA. ABP is biodegraded under reducing conditions, such as the cytoplasm. ABP exhibits much higher transfection efficiency than polyethyleneimine in mammalian cells and exhibits no cytotoxicity.

Abstract: An arginine-grafted bioreducible poly(disulfide amine) (“ABP”) as a reagent for efficient and nontoxic gene delivery is described. ABP forms positively charged nano-particles of less than 200 nm with siRNA. ABP is biodegraded under reducing conditions, such as in the cytoplasm. ABP exhibits much higher transfection efficiency than polyethyleneimine in mammalian cells and exhibits no cytotoxicity. ABP is an effective delivery vehicle for gene silencing with siRNA and may be used for treating cancer.

Abstract: Provided are a method for providing a personalized internet phone, and a terminal using the same.

Abstract: A carrier for delivering small interfering RNA (siRNA) into cells includes a cholesterol residue covalently bonded to oligoarginine. Mixing the siRNA with the carrier produces a complex-containing composition. Contacting a cell with the complex-containing composition results in delivery of the siRNA into the cell. Delivery of an siRNA targeted to vascular endothelial growth factor is a treatment for cancer. Methods of making the carrier and complex are also disclosed.

Abstract: Poly(disulfide amine)s, methods of making, and methods of use are described. Illustrative embodiments of the poly(disulfide amine)s include poly(N,N?-cystaminebisacrylamide-spermine), poly(N,N?-cystaminebisaciylamide-N,N?-bis(3-aminopropyl)1,3-propanediamine), poly(N,N?-cystaminebisacrylamide-N,N?-bis(3-amino-propyl)ethylenediamine), poly(N,N?-cystaminebisacrylamide-N,N?-bis(2-aminoethyl)-1,3-propanediamine), and poly(N,N?-cystaminebisacrylamide-triethylenetetramine). These compositions are made by Michael addition between N,N?-cystaminebisacrylamide and protected oligoamine monomers, followed by deprotection. Complexes are formed by mixing the poly(disulfide amine)s with a nucleic acid. Delivery of the nucleic acid into cells is carried out by contacting the cells with the nucleic acid/poly(disulfide amine) complexes.

Abstract: Plasmids useful for treating ischemic disease, such as ischemic heart disease, are described. The plasmids express vascular endothelial growth factor (VEGF) under the control of a promoter (RTP801) that is up-regulated under hypoxic conditions. Pharmaceutical compositions for treating ischemic disease include mixtures of the hypoxia-regulated VEGF plasmids and pharmaceutically acceptable carriers. Methods for treating ischemic disease include administering such pharmaceutical compositions to a person in need of such treatment.

Abstract: A demodulator capable of compensating for an offset voltage of a radio frequency (RF) signal, and a method of compensating for the offset voltage of the RF signal are provided. The demodulator includes an analog-to-digital conversion (ADC) unit for converting a first analog signal corresponding to a difference between the RF signal comprising the offset voltage and an analog reference signal into a first digital signal, and a compensation voltage generation unit for converting the first digital signal into an offset compensation voltage. The ADC unit converts a second analog signal corresponding to a difference between the RF signal comprising the offset voltage and the offset compensation voltage into a second digital signal. Accordingly, the offset voltage included in the RF signal is compensated for, and thus distortion and a signal-to-noise ratio (SNR) of the RF signal are reduced. This leads to an improvement of the reception sensitivity of an RF receiver.

Abstract: A pellicle frame, including aluminum, aluminum oxide, and a transition metal.

Abstract: Plasmids useful for treating ischemic disease, such as ischemic heart disease, are described. The plasmids express vascular endothelial growth factor (VEGF) under the control of a promoter (RTP801) that is up-regulated under hypoxic conditions. Pharmaceutical compositions for treating ischemic disease include mixtures of the hypoxia-regulated VEGF plasmids and pharmaceutically acceptable carriers. Methods for treating ischemic disease include administering such pharmaceutical compositions to a person in need of such treatment.

Abstract: Linear polyethylenimine was modified with sterols, such as cholesterol, in three different geometries: linear shaped (L), T-shaped (T), and a combined linear- and T-shaped (LT), to result in linear polyethylenimine-sterol conjugates. These conjugates were mixed with nucleic acids to form complexes for delivery of the nucleic acids into cells. Mammalian cells transfected with these complexes showed protein expression levels higher than linear polyethylenimine alone, and twice that of branched polyethylenimine, but without any significant loss in cell viability. Methods of making these compositions and methods of using them for gene delivery are also described.

Abstract: A demodulator capable of compensating for an offset voltage of a radio frequency (RF) signal, and a method of compensating for the offset voltage of the RF signal are provided. The demodulator includes an analog-to-digital conversion (ADC) unit for converting a first analog signal corresponding to a difference between the RF signal comprising the offset voltage and an analog reference signal into a first digital signal, and a compensation voltage generation unit for converting the first digital signal into an offset compensation voltage. The ADC unit converts a second analog signal corresponding to a difference between the RF signal comprising the offset voltage and the offset compensation voltage into a second digital signal. Accordingly, the offset voltage included in the RF signal is compensated for, and thus distortion and a signal-to-noise ratio (SNR) of the RF signal are reduced. This leads to an improvement of the reception sensitivity of an RF receiver.