Patents by Inventor Sunghoon Kwon

Sunghoon Kwon has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20230334662
    Abstract: The present invention relates to a method and apparatus for analyzing pathology patterns of whole-slide images based on graph deep learning, which may include: a whole-slide image (WSI) compression step of compressing WSI into a superpatch graph; a graph neural networks (GNN) analysis step of embedding node features and context features into the superpatch graph through a GNN model and calculating contributions for each node and edge; a biomarker acquisition step of classifying and grouping the superpatch graph according to the contributions for each node, connecting the classified and grouped superpatch graph in units of groups to generate connected graphs, normalizing and clustering features of the connected graphs, and acquiring environmental graph biomarkers for each group; and a diagnostic information extraction step of extracting and providing diagnostic information on the WSI based on the environmental graph biomarker for each group.
    Type: Application
    Filed: March 7, 2023
    Publication date: October 19, 2023
    Inventors: Sunghoon Kwon, Yongju Lee, Kyoungseob Shin, Kyung Chul Moon, Jeong Hwan Park, Sohee Oh
  • Publication number: 20210395346
    Abstract: Described are stereotypic-naïve SARS-CoV-2 neutralizing antibodies that inhibit that SARS-CoV-2 virus replication. The antibodies comprise variable heavy chain (VH) clonotypes, encoded by either immunoglobulin heavy variable (IGHV)3-53 or IGHV3-66 and immunoglobulin heavy joining (IGHJ)6, and were identified in IgM, IgG3, IgG1, IgA1, IgG2, and IgA2 subtypes, with minimal somatic mutations, and could be paired with diverse light chains, resulting in binding to the SARS-CoV-2 receptor-binding domain (RBD). One of these clonotypes potently inhibited viral replication.
    Type: Application
    Filed: June 21, 2021
    Publication date: December 23, 2021
    Inventors: Junho CHUNG, Sang iL Kim, Sujeong Kim, Jinsung Noh, Younggeun Choi, Duck Kyun Yoo, Yonghee Lee, Hyunho Lee, Wan Beom Park, Myoung-don oh, Sunghoon Kwon
  • Patent number: 11062828
    Abstract: Provided is a color encoding method including providing a composition including a liquid medium and magnetic nanoparticles dispersed in the liquid medium; applying a magnetic field to the composition to align the magnetic nanoparticles; and applying a patterned energy source to the composition to solidify the composition, wherein more than one region of the composition are sequentially solidified with varying magnetic field strength to fix a plurality of color codes.
    Type: Grant
    Filed: December 20, 2016
    Date of Patent: July 13, 2021
    Assignee: SNU R&DB FOUNDATION
    Inventors: Sunghoon Kwon, Howon Lee, Junhoi Kim, Hyoki Kim
  • Patent number: 10947575
    Abstract: Provided are a rapid antimicrobial susceptibility test, based on an analysis of changes in morphology and growth pattern of a microbial cell under different concentrations of various antimicrobial agents, and an automated cell image analysis system therefor. The antimicrobial susceptibility test is rapidly performed based on an analysis of changes in morphology and growth pattern of a microbial cell under different concentrations of various antimicrobial agents, and this makes it possible to obtain highly reliable test results faster by six to seven times than the standard method recommended by Clinical and Laboratory Standards Institute (CLSI).
    Type: Grant
    Filed: November 27, 2018
    Date of Patent: March 16, 2021
    Assignee: QUANTAMATRIX INC.
    Inventors: Yong-Gyun Jung, Eun-Geun Kim, Jung Heon Yoo, Sunghoon Kwon, Jungil Choi, Hee Chan Kim, Jung Chan Lee, Eui Jong Kim, Sang Hoon Song, Sei Ick Joo, Ji Soo Lee
  • Patent number: 10929039
    Abstract: Disclosed is a storage method of DNA digital data, including: encoding a plurality of bit data to a plurality of base sequences including at least one degenerate base; and synthesizing at least two types of bases constituting the at least one degenerate base on a substrate based on a mixing ratio.
    Type: Grant
    Filed: September 21, 2018
    Date of Patent: February 23, 2021
    Assignees: UNIVERSITY-INDUSTRY COOPERATION GROUP OF KYUNG HEE UNIVERSITY, SEOUL NATIONAL UNIVERSITY R&DB FOUNDATION
    Inventors: Sunghoon Kwon, Wook Park, Yeongjae Choi, Taehoon Ryu, Suk-Heung Song, Hyeli Kim, Seojoo Kim
  • Patent number: 10883136
    Abstract: Provided is a method of isolating biochemical molecules on a microarray substrate, the method including providing a microarray substrate to which clusters of different kinds of biochemical molecules being classified by individual spot units are attached, the individual spots being regularly arranged thereon; obtaining location information of the individual spot in which a desired cluster among clusters of the biochemical molecules locates; locating an extraction tool for applying energy to isolate the desired cluster according to the location information; and isolating the desired cluster from the microarray substrate by applying energy in a contact or non-contact manner using the extraction tool.
    Type: Grant
    Filed: December 9, 2013
    Date of Patent: January 5, 2021
    Assignee: SNU R&DB FOUNDATION
    Inventors: Sunghoon Kwon, Taehoon Ryu, Yeongjae Choi, Yushin Jung, Hyoki Kim, Howon Lee
  • Patent number: 10676776
    Abstract: A testing method is disclosed. The testing method includes: providing a mixture solution of a gelling agent and a microbe to a gelling device; solidifying the mixture solution to form a solid thin film in which the microbe is immobilized; supplying a bioactive agent to the solid thin film and allowing the bioactive agent to diffuse into the solid thin film; and imaging the individual responses of the single microbial cells to the bioactive agent, and determining the minimum inhibitory concentration (MIC) of the bioactive agent based on the analysis of the images to obtain AST results.
    Type: Grant
    Filed: August 3, 2015
    Date of Patent: June 9, 2020
    Assignee: QUANTAMATRIX INC.
    Inventors: Sunghoon Kwon, Yong-Gyun Jung, Jung Il Choi, Hun Jong Na
  • Patent number: 10557846
    Abstract: Provided are encoded polymeric microparticles and a multiplexed bioassay using the encoded polymeric microparticles. Each of the encoded polymeric microparticles includes an encoded polymeric microparticle core and a silica shell surrounding the microparticle core. Further provided is a method for producing encoded polymeric microparticles. The method includes: mixing a photocurable material with a linker having a functional group polymerizable with the photocurable material and an alkoxysilyl group; applying patterned energy to cure the mixture, followed by encoding to obtain encoded polymeric microparticle cores; and treating the encoded polymeric microparticle cores with a silica precursor to form a silica shell on each encoded polymeric microparticle core.
    Type: Grant
    Filed: November 18, 2013
    Date of Patent: February 11, 2020
    Assignee: QUANTAMATRIX INC.
    Inventors: Sunghoon Kwon, Mira Kim, Jisung Jang, Hyungjong Bae, Nari Kim
  • Patent number: 10533207
    Abstract: The present invention relates to a novel bioactivity testing structure for single cell tracking using a gelling agent and a bioactivity testing system including the testing structure. The present invention also relates to bioactivity testing, drug susceptibility testing, antibiotic screening, and diagnostic methods using the testing structure. The bioactivity testing structure of the present invention enables very rapid and simple drug susceptibility testing of bacteria, particularly Mycobacterium tuberculosis, drug screening, and bacterial diagnosis. Particularly, the use of the testing structure enables DST and diagnosis of bacteria only by pretreatment without the need to concentrate human sputum samples irrespective of inoculum effect, ensuring rapid, accurate, and simple testing compared to conventional tuberculosis diagnosis or DST systems. In addition, the testing structure of the present invention simultaneously enables the diagnosis and drug susceptibility testing of tuberculosis.
    Type: Grant
    Filed: October 16, 2014
    Date of Patent: January 14, 2020
    Assignee: QUANTAMATRIX INC.
    Inventors: Yong-Gyun Jung, Eun Guen Kim, Jung Heon Yoo, Kyung-Ock Park, Sunghoon Kwon, Jungil Choi, Hee jin Kim, Sung Weon Ryoo, Haeun Kim, Hyeon Ju Jeoung, Eun Hee Lee, Hyejin Kim
  • Publication number: 20190317684
    Abstract: Disclosed is a storage method of DNA digital data, including: encoding a plurality of bit data to a plurality of base sequences including at least one degenerate base; and synthesizing at least two types of bases constituting the at least one degenerate base on a substrate based on a mixing ratio.
    Type: Application
    Filed: September 21, 2018
    Publication date: October 17, 2019
    Inventors: Sunghoon Kwon, Wook Park, Yeongjae Choi, Taehoon Ryu, Suk-Heung Song, Hyeli Kim, Seojoo Kim
  • Publication number: 20190136289
    Abstract: Provided are a rapid antimicrobial susceptibility test, based on an analysis of changes in morphology and growth pattern of a microbial cell under different concentrations of various antimicrobial agents, and an automated cell image analysis system therefor. The antimicrobial susceptibility test is rapidly performed based on an analysis of changes in morphology and growth pattern of a microbial cell under different concentrations of various antimicrobial agents, and this makes it possible to obtain highly reliable test results faster by six to seven times than the standard method recommended by Clinical and Laboratory Standards Institute (CLSI).
    Type: Application
    Filed: November 27, 2018
    Publication date: May 9, 2019
    Inventors: Yong-Gyun JUNG, Eun-Geun KIM, Jung Heon YOO, Sunghoon KWON, Jungil CHOI, Hee Chan KIM, Jung Chan LEE, Eui Jong KIM, Sang Hoon SONG, Sei Ick JOO, Ji Soo LEE
  • Patent number: 10274504
    Abstract: Disclosed is a microcapsule encoded depending on the kind of a target substance included therein. The encoded microcapsule has a hydrophilic liquid core including the target substance and a hydrophobic shell surrounding the liquid core. The encoded microcapsule includes graphical codes introduced on the surface of the shell.
    Type: Grant
    Filed: October 28, 2013
    Date of Patent: April 30, 2019
    Assignee: QUANTAMATRIX INC.
    Inventors: Sunghoon Kwon, Younghoon Song, Taehong Kwon, Daewon Lee, Junhoi Kim
  • Patent number: 10220367
    Abstract: Provided is a method of forming a microsphere having a structural color, which includes providing a composition for generating a structural color including a curable material and magnetic nanoparticles dispersed in the curable material, forming an emulsion by adding the composition for generating a structural color to an immiscible solvent, arranging the magnetic nanoparticles located in the emulsion droplet of the curable material in a one-dimensional chain structure by applying a magnetic field to the emulsion, and fixing the chain structure by curing the emulsion droplet.
    Type: Grant
    Filed: August 9, 2016
    Date of Patent: March 5, 2019
    Assignee: SNU R&DB FOUNDATION
    Inventors: Sunghoon Kwon, Hyoki Kim, Yadong Yin, Jianping Ge
  • Publication number: 20190056294
    Abstract: Provided is a method for selectively separating samples from a substrate. The method includes: providing a substrate mounted with samples; selecting one or more desired target areas from areas of a layer of the samples; patterning an energy source so as to correspond to the target areas; and extracting energy from the patterned energy source, applying the extracted energy to the target areas such that target samples corresponding to the target areas are released from the substrate, and recovering the target samples.
    Type: Application
    Filed: October 27, 2016
    Publication date: February 21, 2019
    Inventors: Sunghoon KWON, Sungsik KIM, Yushin JUNG, Amos Chungwon LEE, Sangwook BAE, Jinhyun KIM
  • Patent number: 10208328
    Abstract: Provided are a rapid antimicrobial susceptibility test, based on an analysis of changes in morphology and growth pattern of a microbial cell under different concentrations of various antimicrobial agents, and an automated cell image analysis system therefor. The antimicrobial susceptibility test is rapidly performed based on an analysis of changes in morphology and growth pattern of a microbial cell under different concentrations of various antimicrobial agents, and this makes it possible to obtain highly reliable test results faster by six to seven times than the standard method recommended by Clinical and Laboratory Standards Institute (CLSI).
    Type: Grant
    Filed: October 14, 2015
    Date of Patent: February 19, 2019
    Assignee: QUANTAMATRIX INC.
    Inventors: Yong-Gyun Jung, Eun-Geun Kim, Jung Heon Yoo, Sunghoon Kwon, Jungil Choi, Hee Chan Kim, Jung Chan Lee, Eui Jong Kim, Sang Hoon Song, Sei Ick Joo, Ji Soo Lee
  • Patent number: 10155971
    Abstract: A testing method is disclosed. The testing method includes: providing a mixture solution of a gelling agent and a microbe to a gelling device; solidifying the mixture solution to form a solid thin film in which the microbe is immobilized; supplying a bioactive agent to the solid thin film and allowing the bioactive agent to diffuse into the solid thin film; and imaging the individual responses of the single microbial cells to the bioactive agent, and determining the minimum inhibitory concentration (MIC) of the bioactive agent based on the analysis of the images to obtain AST results.
    Type: Grant
    Filed: August 3, 2015
    Date of Patent: December 18, 2018
    Assignee: QUANTAMATRIX INC.
    Inventors: Sunghoon Kwon, Yong-Gyun Jung, Jung Il Choi, Hun Jong Na
  • Patent number: 10013647
    Abstract: Provided is a method of magnetically controlling a magnetic structure, the method including: providing a solution containing magnetic structures, each including a magnetic axis in which magnetic nanoparticles are arranged; and controlling movements of the magnetic structures by applying an external magnetic field to the solution.
    Type: Grant
    Filed: March 31, 2011
    Date of Patent: July 3, 2018
    Assignee: QUANTAMATRIX INC.
    Inventors: Sunghoon Kwon, Howon Lee, Junhoi Kim, Ji Yun Kim
  • Patent number: 9920351
    Abstract: A testing method is disclosed. The testing method includes: providing a mixture solution of a gelling agent and a microbe to a gelling device; solidifying the mixture solution to form a solid thin film in which the microbe is immobilized; supplying a bioactive agent to the solid thin film and allowing the bioactive agent to diffuse into the solid thin film; and imaging the individual responses of the single microbial cells to the bioactive agent, and determining the minimum inhibitory concentration (MIC) of the bioactive agent based on the analysis of the images to obtain AST results.
    Type: Grant
    Filed: July 8, 2015
    Date of Patent: March 20, 2018
    Assignee: QUANTAMATRIX INC.
    Inventors: Sunghoon Kwon, Yong-Gyun Jung, Jung Il Choi, Hun Jong Na
  • Patent number: 9856564
    Abstract: A technique related with a lithography system is disclosed. The lithography system includes at least one target object disposed on a substrate, a processor configured to process an image of the target object to determine an optical pattern for a coating layer of the target object, and an exposure apparatus configured to provide light having the optical pattern determined by the processor to the substrate.
    Type: Grant
    Filed: January 28, 2016
    Date of Patent: January 2, 2018
    Assignee: SNU R&DB FOUNDATION
    Inventors: Sunghoon Kwon, Sueun Chung, Seungah Lee, Jisung Jang, Sangkwon Han
  • Patent number: 9850482
    Abstract: A heterologous DNA barcoding method is provided. The method includes (a) providing a DNA microarray having DNA oligonucleotide spots, which are distinguished from each other by their barcode sequences, (b) providing a microwell array having microwells whose spatial arrangement corresponds to that of the DNA spots on the DNA microarray, (c) loading a solution of samples containing target nucleic acid sequences into the microwells, (d) assembling the DNA microarray to the microwell array to form micro reaction spaces in which the DNA spots are spatially separated by the microwells, (e) allowing the oligonucleotide sequences of the DNA spots to react with the target nucleic acid sequences of the samples in the micro reaction spaces to combine the sequence information of the DNA spots with the sequence information of the samples, and (f) separating the DNA microarray and the microwell array from each other to obtain reaction products including the barcode sequences.
    Type: Grant
    Filed: March 7, 2014
    Date of Patent: December 26, 2017
    Assignee: SEOUL NATIONAL UNIVERSITY R&DB FOUNDATION
    Inventors: Sunghoon Kwon, Junhoi Kim, Taehoon Ryu, Dongyoon Oh, Jaekyung Koh