Abstract: The present invention relates to benzimidazole derivatives having the general formula I, wherein n is 0 or 1; X1 and X2 are independently, at each occurrence, CR5 or N; Y is C1-C6 alkylene, wherein alkylene is optionally substituted with one to two C1-C3 alkyl groups; R1 is selected from the group consisting of hydrogen, halogen, C1-C6 alkoxy, —NH2, —NHR6, —NR7R8 and —NH—(R9)n—R10, n being 0 or 1; R2 is selected from the group consisting of hydrogen, halogen, C1-C6 alkyl, —NH2, —NHR6, —NR7R8 and —NH—(R9)n—R10; R3 is selected from the group consisting of hydrogen, hydroxyl, OR11, —NR7R8, C1-C6 alkoxy, C1-C6 alkyl, C3-C10 cycloalkyl, C1-C3 haloalkyl, —C(O)NHR11, aryl, heteroaryl and heterocyclyl, wherein each of said cycloalkyl, aryl, heteroaryl and heterocyclyl is optionally and independently substituted with one to four Ra groups; and R4 is selected from the group consisting of —NH2, —N(R12)(V)pR13, —NH(V)p—OR14, —NHC(O)R15, and groups of formula 1a shown below, and their use in the treatment of diseases, in

Abstract: The present invention relates to benzimidazole derivatives having the general formula I, wherein n is 0 or 1; X1 and X2 are independently, at each occurrence, CR5 or N; Y is C1-C6 alkylene, wherein alkylene is optionally substituted with one to two C1-C3 alkyl groups; R1 is selected from the group consisting of hydrogen, halogen, C1-C6 alkoxy, —NH2, —NHR6, —NR7R8 and —NH—(R9)n—R10, n being 0 or 1; R2 is selected from the group consisting of hydrogen, halogen, C1-C6 alkyl, —NH2, —NHR6, —NR7R8 and —NH—(R9)n—R10; R3 is selected from the group consisting of hydrogen, hydroxyl, OR11, —NR7R8, C1-C6 alkoxy, C1-C6 alkyl, C3- C10 cycloalkyl, C1-C3 haloalkyl, —C(O)NHR11, aryl, heteroaryl and heterocyclyl, wherein each of said cycloalkyl, aryl, heteroaryl and heterocyclyl is optionally and independently substituted with one to four Ra groups; and R4 is selected from the group consisting of —NH2, —N(R12)(V)pR13, —NH(V)p—OR14, —NHC(O)R15, and groups of formula 1a shown below, and their use in the treatment of diseases, in

Abstract: The present invention refers to: a compound having the general formula (I), wherein n is 0, 1, 2 or; m is 0, 1, 2 or 3; o is 0, 1, 2 or 3; W, X, Y and Z are independently selected from CH, N or N-oxide; A is NR4, C?O, C?S, OP(O)(O), P?O, CH2, or a heteroarly selected from the group consisting of (a), (b), (c), (d), (e), (f), (g); V is C?O, O, S, CH2, or NR5; as well as its use in treating inflammatory diseases such as asthma, COPD, inflammation post infection, arthritis, atherosclerosis, pain and dermatitis.

Abstract: A safety device for a vehicle, which provides a more simple optimized mechanism to function as a load limiter having stable operation characteristics, and allows a reference load for releasing the webbing to vary depending on a change in collision speed, thereby providing increased protection to an occupant. More specifically, the safety device includes a roller, an electric generator, a magnetic force generator and a resistance generator. The roller comes in contact with a webbing and is configured to rotate with movement of the webbing. The electric generator generates electric current via the rotation of the roller, and the magnetic force generator generates a magnetic force via the electric current generated by the electric generator. The resistance force generator provides a resistance force to the rotation of the roller based on a shear force altered by the magnetic force generated by the magnetic force generator.

Abstract: A safety device for a vehicle, which provides a more simple optimized mechanism to function as a load limiter having stable operation characteristics, and allows a reference load for releasing the webbing to vary depending on a change in collision speed, thereby providing increased protection to an occupant. More specifically, the safety device includes a roller, an electric generator, a magnetic force generator and a resistance generator. The roller comes in contact with a webbing and is configured to rotate with movement of the webbing. The electric generator generates electric current via the rotation of the roller, and the magnetic force generator generates a magnetic force via the electric current generated by the electric generator. The resistance force generator provides a resistance force to the rotation of the roller based on a shear force altered by the magnetic force generated by the magnetic force generator.

Abstract: The present invention refers to: a compound having the general formula (I), wherein n is 0, 1, 2 or; m is 0, 1, 2 or 3; o is 0, 1, 2 or 3; W, X, Y and Z are independently selected from CH, N or N-oxide; A is NR4, C?O, C?S, OP(O)(O), P?O, CH2, or a heteroarly selected from the group consisting of (a), (b), (c), (d), (e), (f), (g); V is C?O, O, S, CH2, or NR5; as well as its use in treating inflammatory diseases such as asthma, COPD, inflammation post infection, arthritis, atherosclerosis, pain and dermatitis.

Abstract: An anchor pre-tensioner for seat belt of vehicle improves phenomenon in which a webbing of seat belt is caught in belly of passengers during collision by the vehicle. The anchor pre-tensioner may include: first second wires connected to a lower end of the webbing respectively; a driving cylinder having a piston coupled to ends of the first and second wires; a gas generator supplying a gas pressure for the forward movement of the piston; a first roller supporting the first wire to move in the direction oblique against the bottom of the vehicle during the forward movement of the piston; and a second roller supporting the second wire to move downward when the piston moves forward; wherein the forward movement of the piston pulls the webbing of the seat belt in the direction where the first wire moves and at the same time in the direction perpendicular thereto.

Abstract: An anchor pre-tensioner for seat belt of vehicle improves phenomenon in which a webbing of seat belt is caught in belly of passengers during collision by the vehicle.