Patents by Inventor Sung-Uk Chung

Sung-Uk Chung has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Anti-inflammatory composition containing macrolactin A and a derivative thereof as active ingredients
    Patent number: 9089543
    Abstract: The present invention relates to an anti-inflammatory use of macrolactin compounds such as macrolactin A, 7-O-malonyl macrolactin A and 7-O-succinyl macrolactin A, which are produced from a novel Bacillus strain of Bacillus polyfermenticus KJS-2 (KCCM10769P). The macrolactin compounds provided by the present invention were confirmed to greatly suppress the expression and formation of inducible nitric oxide synthetase (iNOS) and cyclooxygenase-2 (COX-2) which are proteins related to the formation of inflammatory mediators, and to accordingly inhibit the formation of nitric oxide (NO) and of prostaglandin E2 (PGE2) which are the metabolites of the proteins. In addition, the macrolactin compounds provided by the present invention were confirmed to have excellent effects in inhibiting the formation of tumor necrosis factor-alpha (TNF-?), interleukin-1? (IL-1?), interleukin-6 (IL-6) and granulocyte macrophage colony-stimulating factor (GM-CSF), which are pro-inflammatory cytokines.
    Type: Grant
    Filed: May 24, 2010
    Date of Patent: July 28, 2015
    Assignee: DAEWOO PHARMACEUTICAL IND. CO., LTD.
    Inventors: Young-Hoon Ji, Dong-Hee Kim, Jae-Seon Kang, Chun-Gyu Kim, Sung-Uk Chung, Sung-Woo Hwang, Kyung-Ran Kang
  • Anti-angiogenic composition containing macrolactin A and a derivative thereof as active ingredients
    Patent number: 8940788
    Abstract: The present invention relates to an anti-angiogenic composition containing macrolactin compounds such as macrolactin A, 7-O-malonyl macrolactin A, and 7-O-succinyl macrolactin A as active ingredients. The macrolactin compounds according to the present invention strongly suppress angiogenesis in in vivo experiments and can be used as a pharmaceutical composition for preventing or treating diseases caused by angiogenesis.
    Type: Grant
    Filed: July 15, 2013
    Date of Patent: January 27, 2015
    Assignee: Daewoo Pharmaceutical Ind. Co., Ltd.
    Inventors: Young-Hoon Ji, Dong-Hee Kim, Jung-Ae Kim, Jae-Seon Kang, Sung-Uk Chung, Sung-Woo Hwang, Kyung-Ran Kang, You-Ra Kang
  • ANTI-ANGIOGENIC COMPOSITION CONTAINING MACROLACTIN A AND A DERIVATIVE THEREOF AS ACTIVE INGREDIENTS
    Publication number: 20130303600
    Abstract: The present invention relates to an anti-angiogenic composition containing macrolactin compounds such as macrolactin A, 7-O-malonyl macrolactin A, and 7-O-succinyl macrolactin A as active ingredients. The macrolactin compounds according to the present invention strongly suppress angiogenesis in in vivo experiments and can be used as a pharmaceutical composition for preventing or treating diseases caused by angiogenesis.
    Type: Application
    Filed: July 15, 2013
    Publication date: November 14, 2013
    Applicant: DAEWOO PHARMACEUTICAL IND. CO., LTD.
    Inventors: Young-Hoon JI, Dong-Hee KIM, Jung-Ae KIM, Jae-Seon KANG, Sung-Uk CHUNG, Sung-Woo HWANG, Kyung-Ran KANG, You-Ra KANG
  • ANTI-ANGIOGENIC COMPOSITION CONTAINING MACROLACTIN A AND A DERIVATIVE THEREOF AS ACTIVE INGREDIENTS
    Publication number: 20130109745
    Abstract: The present invention relates to an anti-angiogenic composition containing macrolactin compounds such as macrolactin A, 7-O-malonyl macrolactin A, and 7-O-succinyl macrolactin A as active ingredients. The macrolactin compounds according to the present invention strongly suppress angiogenesis in in vivo experiments and can be used as a pharmaceutical composition for preventing or treating diseases caused by angiogenesis.
    Type: Application
    Filed: February 23, 2011
    Publication date: May 2, 2013
    Inventors: Young-Hoon Ji, Dong-Hee Kim, Jung-Ae Kim, Jae-Seon Kang, Sung-Uk Chung, Sung-Woo Hwang, Kyung-Ran Kang, You-Ra Kang
  • ANTI-INFLAMMATORY COMPOSITION CONTAINING MACROLACTIN A AND A DERIVATIVE THEREOF AS ACTIVE INGREDIENTS
    Publication number: 20120071549
    Abstract: The present invention relates to an anti-inflammatory use of macrolactin compounds such as macrolactin A, 7-O-malonyl macrolactin A and 7-O-succinyl macrolactin A, which are produced from a novel Bacillus strain of Bacillus polyfermenticus KJS-2 (KCCM10769P). The macrolactin compounds provided by the present invention were confirmed to greatly suppress the expression and formation of inducible nitric oxide synthetase (iNOS) and cyclooxygenase-2 (COX-2) which are proteins related to the formation of inflammatory mediators, and to accordingly inhibit the formation of nitric oxide (NO) and of prostaglandin E2 (PGE2) which are the metabolites of the proteins. In addition, the macrolactin compounds provided by the present invention were confirmed to have excellent effects in inhibiting the formation of tumor necrosis factor-alpha (TNF-?), interleukin-1? (IL-1?), interleukin-6 (IL-6) and granulocyte macrophage colony-stimulating factor (GM-CSF), which are pro-inflammatory cytokines.
    Type: Application
    Filed: May 24, 2010
    Publication date: March 22, 2012
    Applicant: DAEWOO PHARMACEUTICAL IND. CO., LTD.
    Inventors: Young-Hoon Ji, Dong-Hee Kim, Jae-Seon Kang, Chun-Gyu Kim, Sung-Uk Chung, Sung-Woo Hwang, Kyung-Ran Kang