Abstract: Disclosed are novel compounds of Chemical Formula 1, optical isomers of the compounds, and pharmaceutically acceptable salts of the compounds or the optical isomers. The compounds, isomers, and salts exhibit excellent activity as GLP-1 receptor agonists. In particular, they, as GLP-1 receptor agonists, exhibit excellent glucose tolerance, thus having a great potential to be used as therapeutic agents for metabolic diseases. Moreover, they exhibit excellent pharmacological safety for cardiovascular systems.

Abstract: A method for reducing metal artifacts in computed tomography (CT) is disclosed. The method for reducing metal artifacts in CT includes: obtaining a sinogram reduced in size from an original sinogram; setting up a linear algebraic equation according to remaining data excluding data damaged by a metal based on the obtained sinogram; restoring a low-resolution image based on the set up linear algebraic equation; calculating a sinogram from the restored low-resolution image; restoring a sinogram by disposing the calculated sinogram data in the original sinogram and by utilizing the calculated sinogram data as pre-information; and restoring a final CT image from the restored sinogram. Through introduction of a novel metal artifact reduction (MAR) technique referred to as an algebraic correction technique (ACT) using an intermediate image of an attenuation coefficient of an outside of a metal area, an image closest to an original image can be obtained by minimizing metal artifacts in CT.

Abstract: An apparatus and method for computed tomography image processing is provided. The apparatus includes: an X-ray detection unit that detects an X-ray beam having passed through a subject and outputs an energy value thereof; a line integral calculation unit that calculates line integral values of attenuation coefficients representing attenuation of the energy value of the X-ray beam having passed through the subject and been detected, based on the energy value; an image processing unit that reconstructs a tomogram based on the line integral values; and an image output unit that outputs the tomogram. The apparatus and method for computed tomography image processing can calculate line integral values of attenuation coefficients constituting an integrand of an X-ray projection function using the mean value theorem for integrals in order to restore an image of a subject from an X-ray beam detected in computed tomography image processing.

Abstract: A method for reducing metal artifacts in computed tomography (CT) is disclosed. The method for reducing metal artifacts in CT includes: obtaining a sinogram reduced in size from an original sinogram; setting up a linear algebraic equation according to remaining data excluding data damaged by a metal based on the obtained sinogram; restoring a low-resolution image based on the set up linear algebraic equation; calculating a sinogram from the restored low-resolution image; restoring a sinogram by disposing the calculated sinogram data in the original sinogram and by utilizing the calculated sinogram data as pre-information; and restoring a final CT image from the restored sinogram. Through introduction of a novel metal artifact reduction (MAR) technique referred to as an algebraic correction technique (ACT) using an intermediate image of an attenuation coefficient of an outside of a metal area, an image closest to an original image can be obtained by minimizing metal artifacts in CT.

Abstract: An apparatus and method for computed tomography image processing is provided. The apparatus includes: an X-ray detection unit that detects an X-ray beam having passed through a subject and outputs an energy value thereof; a line integral calculation unit that calculates line integral values of attenuation coefficients representing attenuation of the energy value of the X-ray beam having passed through the subject and been detected, based on the energy value; an image processing unit that reconstructs a tomogram based on the line integral values; and an image output unit that outputs the tomogram. The apparatus and method for computed tomography image processing can calculate line integral values of attenuation coefficients constituting an integrand of an X-ray projection function using the mean value theorem for integrals in order to restore an image of a subject from an X-ray beam detected in computed tomography image processing.

Abstract: The present invention relates to a method of isolating and culturing mesenchymal stem cells using umbilical cord blood that is most ideal for cell therapy. The method comprises adding an anti-coagulant to umbilical cord blood having a volume of more than 45 ml per unit, which is obtained within 24 hours after parturition; diluting the resulting mixture of the anti-coagulant and umbilical cord blood with an ?MEM (alpha-minimum essential medium), followed by centrifugation to harvest monocytes; and subjecting the obtained monocytes into suspension culture in the ?MEM containing Stem Cell Factor, GM-CSF (granulocyte-macrophage colony-stimulating factor), G-CSF (granulocyte colony-stimulating factor), IL-3 (interleukin-3) and IL-6 (interleukin-6).

Abstract: The present invention relates to a method of isolating and culturing mesenchymal stem cells using cryopreserved umbilical cord blood that is most ideal for cell therapy. The method comprises thawing cryopreserved umbilical cord blood and adding ?MEM (alpha-minimum essential medium) thereto, followed by centrifugation to harvest monocytes; isolating CD133 positive cells from the obtained monocytes; and subjecting the isolated cells into suspension culture in the ?MEM containing Stem Cell Factor, GM-CSF (granulocyte-macrophage colony-stimulating factor), G-CSF (granulocyte colony-stimulating factor), IL-3 (interleukin-3) and IL-6 (interleukin-6).

Abstract: The present invention relates to a method of isolating and culturing mesenchymal stem cells using cryopreserved umbilical cord blood that is most ideal for cell therapy. The method comprises thawing cryopreserved umbilical cord blood and adding ?MEM (alpha-minimum essential medium) thereto, followed by centrifugation to harvest monocytes; isolating CD133 positive cells from the obtained monocytes; and subjecting the isolated cells into suspension culture in the ?MEM containing Stem Cell Factor, GM-CSF (granulocyte-macrophage colony-stimulating factor), G-CSF (granulocyte colony-stimulating factor), IL-3 (interleukin-3) and IL-6 (interleukin-6).

Abstract: The present invention relates to a method of isolating and culturing mesenchymal stem cells using umbilical cord blood that is most ideal for cell therapy. The method comprises adding an anti-coagulant to umbilical cord blood having a volume of more than 45 ml per unit, which is obtained within 24 hours after parturition; diluting the resulting mixture of the anti-coagulant and umbilical cord blood with an ?MEM (alpha-minimum essential medium), followed by centrifugation to harvest monocytes; and subjecting the obtained monocytes into suspension culture in the ?MEM containing Stem Cell Factor, GM-CSF (granulocyte-macrophage colony-stimulating factor), G-CSF (granulocyte colony-stimulating factor), IL-3 (interleukin-3) and IL-6 (interleukin-6).