Patents by Inventor Sunil Acharya
Sunil Acharya has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240408203Abstract: Embodiments of the disclosure encompass particular chimeric antigen receptor constructs that comprise optionally a hinge, one of the CD28 transmembrane domain or the DAP10 transmembrane domain, DAP10 costimulatory domain, and CD3zeta. In particular embodiments, the chimeric antigen receptor is expressed by natural killer (NK) cells, and in some cases the NK cells are further modified, such as to express one or more cytokines and optionally a suicide gene.Type: ApplicationFiled: October 19, 2022Publication date: December 12, 2024Applicant: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEMInventors: Katy REZVANI, May DAHER, Rafet BASAR, Sunil ACHARYA, Nadima UPRETY, Ana Karen NUNEZ CORTES, Emily ENSLEY
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Publication number: 20240382593Abstract: Aspects of the present disclosure are directed to immune cells comprising polynucleotides encoding genetically engineered receptors (e.g., chimeric antigen receptors, T-cell receptors) and having anti-CD20 antibodies (or fragments thereof) attached to their surface. Certain aspects are directed to preactivated and/or expanded natural killer cells having anti-CD20 antibodies (or fragments thereof) attached to their surface. Also disclosed are compositions comprising such cells, and methods for using such compositions to treat an individual having CD20-positive cancer. Further aspects encompass methods for cell preparation comprising culturing natural killer cells with cytokines (e.g., IL-12, IL-15, and/or IL-18) and incubating the cells with an anti-CD20 antibody.Type: ApplicationFiled: September 29, 2022Publication date: November 21, 2024Applicant: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEMInventors: Katy REZVANI, Elizabeth J. SHPALL, Rafet BASAR, Sunil ACHARYA, David MARIN COSTA
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Publication number: 20240325444Abstract: Embodiments of the disclosure include methods and compositions related to targeting of TROP-2-expressing cells with particular engineered receptors. In specific embodiments, NK cells are specifically engineered to bind TROP-2 using particular chimeric antigen receptor constructs. In certain embodiments, vectors that express the TROP-2-targeting CARs also express a particular suicide gene and/or one or more particular cytokines.Type: ApplicationFiled: July 8, 2022Publication date: October 3, 2024Applicant: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEMInventors: Katy REZVANI, Sunil ACHARYA, Funda MERIC-BERNSTAM, Nadima UPRETY, Rafet BASAR, David MARIN COSTA
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Publication number: 20240269285Abstract: Embodiments of the present disclosure include methods and compositions related to CD70-targeting polypeptides. In certain aspects, anti-CD70 antibodies are disclosed. In some aspects, disclosed are chimeric receptors engineered to bind to CD70. Also disclosed are immune cell engagers comprising a CD70-binding region and one or more immune cell binding regions. Cells (e.g., NNK cells, T cells) expressing CD70-targeting peptides are described. Also described are therapeutic methods using polypeptides of the disclosure.Type: ApplicationFiled: June 29, 2022Publication date: August 15, 2024Applicant: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEMInventors: Katy REZVANI, Laura del Carmen BOVER, Rafet BASAR, Sunil ACHARYA, Long VIEN, Nadima UPRETY, Emily ENSLEY
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Publication number: 20240252539Abstract: Embodiments of the disclosure include methods and compositions related to targeting of HLA-G-expressing cells with particular engineered receptors. In specific embodiments, NK cells are specifically engineered to bind HLA-G using particular chimeric antigen receptor constructs. In certain embodiments, vectors that express the HLA-G-targeting CARs also express particular a suicide gene and/or one or more particular cytokines.Type: ApplicationFiled: May 26, 2022Publication date: August 1, 2024Applicant: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEMInventors: Katy REZVANI, Elizabeth J. SHPALL, Rafet BASAR, Sunil ACHARYA, Nadima UPRETY, David MARIN COSTA, Emily ENSLEY
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Publication number: 20240189357Abstract: Embodiments of the disclosure include methods and compositions related to targeting of CD5-expressing cells with particular engineered receptors. In specific embodiments, NK cells are specifically engineered to bind the CD5 antigen using particular chimeric antigen receptor constructs. In certain embodiments, vectors that express the CD5-targeting CARs also express particular a suicide gene and/or one or more particular cytokines.Type: ApplicationFiled: April 14, 2022Publication date: June 13, 2024Inventors: Katy REZVANI, Elizabeth SHPALL, Rafet BASAR, May DAHER, Sunil ACHARYA, Nadima UPRETY, Ana Karen NUNEZ CORTES, Emily ENSLEY, David MARIN COSTA
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Patent number: 11406643Abstract: Provided herein are methods for the treatment of brain metastasis by administering a kinase inhibitor targeted to a metastasis-promoting kinase identified by an in vivo kinase screen.Type: GrantFiled: August 10, 2018Date of Patent: August 9, 2022Assignee: Board of Regents, The University of Texas SystemInventors: Dihua Yu, Frank Lowery, Chenyu Zhang, Sunil Acharya, Ping Li
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Publication number: 20200197407Abstract: Provided herein are methods for the treatment of brain metastasis by administering a kinase inhibitor targeted to a metastasis-promoting kinase identified by an in vivo kinase screen.Type: ApplicationFiled: August 10, 2018Publication date: June 25, 2020Inventors: Dihua YU, Frank LOWERY, Chenyu ZHANG, Sunil ACHARYA, Ping LI
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Patent number: 9442186Abstract: Embodiments disclosed herein are directed to time-of-flight (TOF) systems, and methods for use therewith, that substantially reduce interference that the TOF system may cause to at least one other system that is configured to wirelessly receive and respond to IR light signals. Some such embodiments involve emitting IR light having a low frequency (LF) power envelope that is shaped to substantially reduce frequency content within at least one frequency range known to be used by at least one other system that may be in close proximity to the TOF system. Such embodiments can also involve detecting at least a portion of the emitted RF modulated IR light that has reflected off one or more objects. A TOF system can produce depth images in dependence on results of the detecting, as well as update an application in dependence on the depth images.Type: GrantFiled: October 16, 2013Date of Patent: September 13, 2016Assignee: MICROSOFT TECHNOLOGY LICENSING, LLCInventors: Andrew Payne, Cyrus Bamji, Dawson Yee, Barry Thompson, Zhanping Xu, Brock Roland, Larry Prather, Travis Perry, Mike Fenton, Sunil Acharya, Algird Gudaitis, Matthew Morris
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Publication number: 20140333917Abstract: Embodiments disclosed herein are directed to time-of-flight (TOF) systems, and methods for use therewith, that substantially reduce interference that the TOF system may cause to at least one other system that is configured to wirelessly receive and respond to IR light signals. Some such embodiments involve emitting IR light having a low frequency (LF) power envelope that is shaped to substantially reduce frequency content within at least one frequency range known to be used by at least one other system that may be in close proximity to the TOF system. Such embodiments can also involve detecting at least a portion of the emitted RF modulated IR light that has reflected off one or more objects. A TOF system can produce depth images in dependence on results of the detecting, as well as update an application in dependence on the depth images.Type: ApplicationFiled: October 16, 2013Publication date: November 13, 2014Applicant: Microsoft CorporationInventors: Andrew Payne, Cyrus Bamji, Dawson Yee, Barry Thompson, Zhanping Xu, Brock Roland, Larry Prather, Travis Perry, Mike Fenton, Sunil Acharya, Algird Gudaitis, Matthew Morris
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Patent number: 8681124Abstract: A system recognizes user-object gesture interactions with the surface of a monitor display, with hover space defined spaced-apart from the display surface, or in virtual scroll regions defined on the periphery of the monitor display. The system recognizes user-object interactions, e.g., gestures, and can affect what is displayed commensurately. The system includes at least a first time-of-flight (TOF) system and at least one of a second TOF, a two-dimensional camera, and a mirror, each TOF system processing at least one of z-depth data and A-brightness data. User-object interactions, e.g., touching(s) of the display surface, location(s) in a hover region, or location(s) in a virtual scroll region, are recognized passively in that the user-object need not have capacitance, resistance, exert force, or deform during gesture interaction. The system may be attached retroactively to the monitor, which may be a large (>22 cm) monitor, or a small cell phone sized monitor.Type: GrantFiled: September 22, 2009Date of Patent: March 25, 2014Assignee: Microsoft CorporationInventors: Cyrus Bamji, Sunil Acharya
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Patent number: 8589033Abstract: Time-of-flight (TOF) three-dimensional sensing systems are deployed on or in a motor vehicle to image contact zones associated with potential contact between an avoidable object and the vehicle or vehicle frame and/or remotely controllable motorized moving door or liftgate. An algorithm processes depth data acquired by each TOF system to determine whether an avoidable object is in the associated contact zone. If present, a control signal issues to halt or reverse the mechanism moving the door. A stored database preferably includes a depth image of the contact zone absent any object, an image of the door, and volume of the door. Database images are compared to newly acquired depth images to identify pixel sensors whose depth values are statistically unlikely to represent background or the door. Pixels within the contact zone so identified are an object, and the control signal is issued.Type: GrantFiled: January 11, 2008Date of Patent: November 19, 2013Assignee: Microsoft CorporationInventors: Abbas Rafii, Richard New, Sunil Acharya, Timothy Droz
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Publication number: 20120011454Abstract: The present invention mines or extracts data present during interaction between at least two participants, for example in a chat session, a video session, etc. via the Internet. The data, which can include participant web camera generated video, audio, keyboard typed information, handwriting recognized information, is analyzed. Based upon the analysis, content-dependent information is determined and may be displayed to one or more participants in the chat session. In one aspect, a video foreground based upon a participant's generated video is combined with a customized computer generated background that is based upon data mined from the chat session. The customized background preferably is melded seamlessly with the participant's foreground data, preferably via background substitution that combines RGB video with depth data that predicts what background may substituted with new imagery. Content-based targeted information can include advertisement(s).Type: ApplicationFiled: April 30, 2009Publication date: January 12, 2012Inventors: Timothy Droz, Sunil Acharya, Cyrus Bamji
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Publication number: 20110295469Abstract: Time-of-flight (TOF) three-dimensional sensing systems are deployed on or in a motor vehicle to image contact zones associated with potential contact between an avoidable object and the vehicle or vehicle frame and/or remotely controllable motorized moving door or liftgate. An algorithm processes depth data acquired by each TOF system to determine whether an avoidable object is in the associated contact zone. If present, a control signal issues to halt or reverse the mechanism moving the door. A stored database preferably includes a depth image of the contact zone absent any object, an image of the door, and volume of the door. Database images are compared to newly acquired depth images to identify pixel sensors whose depth values are statistically unlikely to represent background or the door. Pixels within the contact zone so identified are an object, and the control signal is issued.Type: ApplicationFiled: January 11, 2008Publication date: December 1, 2011Applicant: CANESTA, INC.Inventors: Abbas Rafii, Richard New, Sunil Acharya, Timothy Droz
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Publication number: 20110291988Abstract: A system recognizes user-object gesture interactions with the surface of a monitor display, with hover space defined spaced-apart from the display surface, or in virtual scroll regions defined on the periphery of the monitor display. The system recognizes user-object interactions, e.g., gestures, and can affect what is displayed commensurately. The system includes at least a first time-of-flight (TOF) system and at least one of a second TOF, a two-dimensional camera, and a mirror, each TOF system processing at least one of z-depth data and A-brightness data. User-object interactions, e.g., touching(s) of the display surface, location(s) in a hover region, or location(s) in a virtual scroll region, are recognized passively in that the user-object need not have capacitance, resistance, exert force, or deform during gesture interaction. The system may be attached retroactively to the monitor, which may be a large (>22 cm) monitor, or a small cell phone sized monitor.Type: ApplicationFiled: September 22, 2009Publication date: December 1, 2011Applicant: CANESTA, INC.Inventors: Cyrus Bamji, Sunil Acharya
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Publication number: 20110292181Abstract: User interaction with a device is sensed using a three-dimensional imaging system. The system preferably includes a library of user profiles and upon acquiring a three-dimensional images of a user can uniquely identify the user, and activate appliances according to user preferences in the user profile. The system can also use data from the acquired image of the user's face to confirm identity of the user, for purposes of creating a robust biometric password. Acquired three dimensional data can measure objects to provide automated, rapid and accurate measurement data, can provide image stabilization data for cameras and the like, and can create virtual three-dimensional avatars that mimic a user's movements and expressions and can participate in virtual world activities. Three-dimensional imaging enables a user to directly manipulate a modeled object in three-dimensional space.Type: ApplicationFiled: April 16, 2009Publication date: December 1, 2011Inventors: Sunil Acharya, Steve Ackroyd
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Patent number: 6437262Abstract: A handle operating assembly suitable for use with an electric disconnect switch assembly having a circuit breaker. The handle operating assembly comprises a handle operator extending outward from the electric disconnect switch and movable between an ON and an OFF position and a face plate having a slot therein. The handle operator slidably moves in the slot between the OFF position and the ON position. The face plate mounts to the electric disconnect switch assembly and is positionable between a first position to prevent access to the circuit breaker and a second position to provide access to the circuit breaker. The handle operating assembly provides ease of accessibility to the electrical disconnect switch and ease of assembly.Type: GrantFiled: February 28, 2001Date of Patent: August 20, 2002Assignee: General Electric CompanyInventors: Pankaj Gupta, Ranjit Sunil Acharya, Amit Narang, John Joseph Struble, Jr., Edgar Yee, David Edward Thorn, Elwood Rau Combs
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Patent number: 6423913Abstract: A locking device for use on an electric disconnect switch having a handle operator assembly. The locking device includes a slide plate slidably positioned within the housing and a first lock arranged to engage said slide plate and secure the handle operator assembly in an engaged position.Type: GrantFiled: February 28, 2001Date of Patent: July 23, 2002Assignee: General Electric CompanyInventors: Pankaj Gupta, Ranjit Sunil Acharya, Amit Narang, John Joseph Struble, Jr., Edgar Yee, David Edward Thorn, Elwood Rau Combs