Abstract: Disclosed herein are DNA amplification methods for quantifying DNA fragments of a target DNA in a sample by size. This can be used, for example, to detect tumor-derived viral DNA in blood sample and distinguish it from larger viral DNA from non-tumor sources. In particular, disclosed herein are methods of detecting, monitoring or treating a human papilloma virus (HPV)-associated malignancy in a subject that involves detecting a presence or absence of at least one circulating tumor-derived HPV DNA in a sample from the subject. Kits for accomplishing the same are also provided.

Abstract: Aspects of the subject technology relate to a system configured to receive a set of network snapshot segments from an output stream of a stream processing service, compile the set of network snapshot segments from the set of messages into a first network snapshot and a second network snapshot, and compare the first network snapshot and the second network snapshot to identify a difference between the first network snapshot and the second network snapshot.

Abstract: The present disclosure provides methods and compositions of modified oligonucleotide primer and probe combinations, structurally modified with locked nucleic acids, quenchers, and dyes, effective to detect tumor-derived Human Papilloma Virus (HPV) and tumor-derived Epstein-Barr virus (EBV) and, especially, to distinguish viral DNA derived from tumors from viral DNA derived from infectious viral particles.

Abstract: A shutdown criterion is determined to be met with respect to a cluster. Responsive to determining that the shutdown criterion is met, a request router is configured to route requests addressed to the cluster to a destination that indicates that the cluster is unavailable. A request to shut down the cluster is transmitted. A request to start the cluster is received. The request is initiated via the destination that indicates that the cluster is unavailable. In response to receiving the request to start the cluster, the cluster is started and the request router is configured to direct, to the cluster, requests addressed to the cluster.

Abstract: A system for intra-operatively registering a pelvis comprising an acetabulum with a computer model of the pelvis in a coordinate system. The system may include: a) a surgical navigation system including a tracking device; and b) at least one computing device in communication with the surgical navigation system. The at least one computing device: i) receiving first data points from first intra-operatively collected points on an articular surface of the acetabulum, the first data points collected with the tracking device; ii) receiving a second data point from a second intra-operatively collected point on the pelvis, the second data point collected with the tracking device, the second data point corresponding in location to a second virtual data point on the computer model; and iii) determining an intra-operative center of rotation of the femur relative to the pelvis from the first data points.

Abstract: A registration system including a bone pin guide and a bone pin clamp. The bone pin guide may include a guide body, a first guide including a first guide through-hole having a first longitudinal axis, and a second guide including a second guide through-hole having a second longitudinal axis. The bone pin guide may guide first and second bone pins into a bone via the first and second guides. The bone pin clamp may include a clamp body, first, second, and third clamp through-holes extending through the clamp body, a plurality of registration indents defined on the clamp body, and a clamping mechanism including at least one adjustable fastener. The bone pin clamp may receive the first and second bone pins in the first and third clamp through-holes and guide a third bone pin into the bone via the second clamp through-hole.

Abstract: A system for intra-operatively registering a pelvis comprising an acetabulum with a computer model of the pelvis in a coordinate system. The system may include: a) a surgical navigation system including a tracking device; and b) at least one computing device in communication with the surgical navigation system. The at least one computing device: i) receiving first data points from first intra-operatively collected points on an articular surface of the acetabulum, the first data points collected with the tracking device; ii) receiving a second data point from a second intra-operatively collected point on the pelvis, the second data point collected with the tracking device, the second data point corresponding in location to a second virtual data point on the computer model; and iii) determining an intra-operative center of rotation of the femur relative to the pelvis from the first data points.

Abstract: A method and/or system for dynamic generation of charts in a personalized video content is disclosed. A client device may receive user data, a video template and a metadata associated with the video template over a computer network. The dynamic generation of the personalized video is performed at the client device by transforming the user data to a graphical overlay elements using charting libraries by generating an enriched data object based on the user data and the metadata. The graphical overlay elements are overlaid dynamically on top of the video template while playing the video template at the client device.

Abstract: A method and/or system for dynamic generation of personalized video content in a conversational interface is disclosed. A chat application at a client device receives input from user which is communicated to chatbot platform. The chatbot platform composes a response in a data package and communicates to the chat application. If the format of the data package is of the type ‘Personalized Smart Video’, then a personalized video generation engine may generate a personalized video using a video template by displaying the video template and dynamically overlaying transformed user data on top of dedicated placeholders in the video template, thereby enhancing the user experience by rendering messages in form of personalized video at the client device and eliminating the need of creating a separate video file for each target user.

Abstract: The disclosed technology relates to intent driven network management. A system is configured to maintain an inventory store comprising records for a set of network entities in a network, wherein each network entity in the set of network entities is associated with a record in the inventory store. The system receives a user intent statement comprising an action and a flow filter representing network data flows on which the action is to be applied and queries, based on the flow filter, the inventory store to identify a plurality of network entities in the set of network entities to which the user intent statement applies. The system generates a plurality of network policies that implement the user intent statement based on the plurality of network entities and the action and enforces the plurality network policies.

Abstract: A registration system including a bone pin guide and a bone pin clamp. The bone pin guide may include a guide body, a first guide including a first guide through-hole having a first longitudinal axis, and a second guide including a second guide through-hole having a second longitudinal axis. The bone pin guide may guide first and second bone pins into a bone via the first and second guides. The bone pin clamp may include a clamp body, first, second, and third clamp through-holes extending through the clamp body, a plurality of registration indents defined on the clamp body, and a clamping mechanism including at least one adjustable fastener. The bone pin clamp may receive the first and second bone pins in the first and third clamp through-holes and guide a third bone pin into the bone via the second clamp through-hole.

Abstract: A system for controlling access to equipment. The system establishes that a user of a mobile device has authorization to access an equipment and generates an encrypted digital key. The system sends the encrypted digital key to the mobile device. The system also sends an encrypted corresponding digital key to a controlling unit of the equipment. When a distance between the mobile device and the controlling unit is within a threshold, and the encrypted digital key transmitted by the mobile device is authenticated by the encrypted corresponding key on the controlling unit, the controlling unit unlocks the equipment so that the user of the mobile device takes control of the equipment in accordance with terms and conditions as set forth in a contract for operating the equipment between the user and an owner of the system.

Abstract: Disclosed is a system for vascular access, where the system allows for transitions between retrograde and antegrade access without generation of multiple access sites and without inducing extensive vascular damage. In embodiments, the system can include a vascular access portion including a body with a first lumen for preferentially providing access in a retrograde direction into a vessel, and a second lumen for preferentially providing access in an antegrade direction into the vessel. The body can be transitioned (e.g., by way of expansion, contraction, or other deformation mode) between a retrograde delivery mode and an antegrade delivery mode.

Abstract: The disclosed technology relates to intent driven network management. A system is configured to maintain an inventory store comprising records for a set of network entities in a network, wherein each network entity in the set of network entities is associated with a record in the inventory store. The system receives a user intent statement comprising an action and a flow filter representing network data flows on which the action is to be applied and queries, based on the flow filter, the inventory store to identify a plurality of network entities in the set of network entities to which the user intent statement applies. The system generates a plurality of network policies that implement the user intent statement based on the plurality of network entities and the action and enforces the plurality network policies.

Abstract: An integrated circuit is described. The integrated circuit (IC) may include a printed circuit board (PCB). The IC may also include a system on chip (SoC) die on the PCB. The IC may further include a memory device coupled to a parallel memory interface of the SoC die. The memory device may be coupled to a parallel memory interface through parallel signal traces arranged in an asymmetric routing. In the asymmetric routing of the parallel signal traces, the signal traces are arranged according to a variable spacing is between the parallel signal traces for a majority portion of the parallel signal traces.

Abstract: Systems, methods, and computer-readable for defining host functionalities in a computing environment include obtaining two or more snapshots comprising information pertaining to two or more processes executing in two or more hosts, the two or more snapshots being obtained at two or more points in time from the two or more hosts. One or more long-running processes amongst the two or more processes are identified based on one or more criteria associated with long-running processes. One or more priorities associated with the one or more long-running processes and used for defining functionalities for at least a subset of the two or more hosts, where high priorities are assigned to long-running processes, such as web server or database server processes, which are unique to at least the subset of the two or more hosts. Resources may be provisioned based on these host functionalities.

Abstract: A system for intra-operatively registering a pelvis comprising an acetabulum with a computer model of the pelvis in a coordinate system. The system may include: a) a surgical navigation system including a tracking device; and b) at least one computing device in communication with the surgical navigation system. The at least one computing device: i) receiving first data points from first intra-operatively collected points on an articular surface of the acetabulum, the first data points collected with the tracking device; ii) receiving a second data point from a second intra-operatively collected point on the pelvis, the second data point collected with the tracking device, the second data point corresponding in location to a second virtual data point on the computer model; and iii) determining an intra-operative center of rotation of the femur relative to the pelvis from the first data points.

Abstract: A method and/or system for dynamic generation of personalized video content in a conversational interface is disclosed. A chat application at a client device receives input from user which is communicated to chatbot platform. The chatbot platform composes a response in a data package and communicates to the chat application. If the format of the data package is of the type ‘Personalized Smart Video’, then a personalized video generation engine may generate a personalized video using a video template by displaying the video template and dynamically overlaying transformed user data on top of dedicated placeholders in the video template, thereby enhancing the user experience by rendering messages in form of personalized video at the client device and eliminating the need of creating a separate video file for each target user.

Abstract: The disclosed technology relates to a network agent for generating platform specific network policies. A network agent is configured to receive a platform independent network policy from a network policy system, determine implementation characteristics of the network entity, generate platform specific policies from the platform independent network policy based on the implementation characteristics of the network entity, and implement the platform specific policies on the network entity.

Abstract: A system for intra-operatively registering a pelvis comprising an acetabulum with a computer model of the pelvis in a coordinate system. The system may include: a) a surgical navigation system including a tracking device; and b) at least one computing device in communication with the surgical navigation system. The at least one computing device: i) receiving first data points from first intra-operatively collected points on an articular surface of the acetabulum, the first data points collected with the tracking device; ii) receiving a second data point from a second intra-operatively collected point on the pelvis, the second data point collected with the tracking device, the second data point corresponding in location to a second virtual data point on the computer model; and iii) determining an intra-operative center of rotation of the femur relative to the pelvis from the first data points.