Patents by Inventor Sunil J. Advani

Sunil J. Advani has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Tumor radiosensitization with monomethyl auristatin E (MMAE) and derivatives thereof
    Patent number: 10596259
    Abstract: Disclosed herein, the invention pertains to methods and compositions that find use in radiosensitization of tumors and tumor samples based on the ability of a tumor sample to cleave a MTS molecule of the present invention. The MTS molecules of the present invention have a formula as disclosed herein and wherein A is a peptide with a sequence comprising 5 to 9 consecutive acidic amino acids, wherein the amino acids are selected from: aspartates and glutamates; B is a peptide with a sequence comprising 5 to 20 consecutive basic amino acids; X and Y are linkers; P is an optional pre-targeting moiety; M is an optional macromolecular carrier; and T is a radiosensitization agent for delivery to a target, including for example a therapeutic compound.
    Type: Grant
    Filed: May 20, 2016
    Date of Patent: March 24, 2020
    Assignee: The Regents of the University of California
    Inventors: Elamprakash N. Savariar, Sunil J. Advani, Roger Y. Tsien
  • TUMOR RADIOSENSITIZATION WITH ANTIBODY CONJUGATES
    Publication number: 20180140703
    Abstract: Disclosed herein, the invention pertains to methods and compositions that find use in radiosensitization of tumors and tumor samples based on the ability of a tumor sample to cleave a MTS molecule of the present invention. The MTS molecules of the present invention have a formula as disclosed herein and wherein A is a peptide with a sequence comprising 5 to 9 consecutive acidic amino acids, wherein the amino acids are selected from: aspartates and glutamates; B is a peptide with a sequence comprising 5 to 20 consecutive basic amino acids; X and Y are linkers; P is an optional pre-targeting moiety; M is an optional macromolecular carrier; and T is a radiosensitization agent for delivery to a target, including for example a therapeutic compound, wherein T is not an auristatin, including MMAE, or a derivative thereof.
    Type: Application
    Filed: November 17, 2017
    Publication date: May 24, 2018
    Inventors: Sunil J. Advani, Stephen Adams, Roger Y. Tsien
  • TUMOR RADIOSENSITIZATION WITH MONOMETHYL AURISTATIN E (MMAE) AND DERIVATIVES THEREOF
    Publication number: 20170080088
    Abstract: Disclosed herein, the invention pertains to methods and compositions that find use in radiosensitization of tumors and tumor samples based on the ability of a tumor sample to cleave a MTS molecule of the present invention. The MTS molecules of the present invention have a formula as disclosed herein and wherein A is a peptide with a sequence comprising 5 to 9 consecutive acidic amino acids, wherein the amino acids are selected from: aspartates and glutamates; B is a peptide with a sequence comprising 5 to 20 consecutive basic amino acids; X and Y are linkers; P is an optional pre-targeting moiety; M is an optional macromolecular carrier; and T is a radiosensitization agent for delivery to a target, including for example a therapeutic compound.
    Type: Application
    Filed: May 20, 2016
    Publication date: March 23, 2017
    Inventors: Elamprakash N. Savariar, Sunil J. Advani, Roger Y. Tsien