Abstract: A cancer test includes: processing a suspect tissue sample (10) acquired from a subject (6) to generate a suspect whole genome sequence (WGS) (20); processing a normal tissue sample (12) acquired from the subject to generate a normal WGS (22); computing a WGS comparison metric comparing the suspect WGS with the normal WGS; and identifying whether the suspect tissue sample comprises cancer tissue based on the computed WGS comparison metric. A tumor delineation method comprises: acquiring a plurality of probative tissue samples (104) from a subject (6) in or near a tumor (100); recording the sampling locations of the probative tissue samples; classifying each probative tissue sample respective to cancer based on genetic testing of the probative tissue sample; and delineating a boundary (110) of the tumor based on the classifications of the probative tissue samples and the recorded sampling locations.