Patents by Inventor Sunil Kumar Saini

Sunil Kumar Saini has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for producing an examination reagent and kit for analysing a T-cell frequency
    Patent number: 11698375
    Abstract: A method for producing an examination reagent includes adding a helper ligand to a receptor protein which is unfolded in an initial solution so as to provide a pre-solution of the examination reagent with a receptor protein which is folded. The receptor protein which is folded comprises a bonded helper ligand which can be exchanged with an examination peptide.
    Type: Grant
    Filed: July 1, 2019
    Date of Patent: July 11, 2023
    Assignee: CONSTRUCTOR UNIVERSITY BREMEN GGMBH
    Inventors: Sebastian Hartmut Springer, Sunil Kumar Saini
  • HIGH THROUGHPUT EPITOPE IDENTIFICATION AND T CELL RECEPTOR SPECIFICITY DETERMINATION USING LOADABLE DETECTION MOLECULES
    Publication number: 20230147726
    Abstract: The present invention relates to detection of interactions between antigenic peptides and binding partners, such as T cell receptors (TCR) and antigenic peptide responsive T cells. In particular, the present invention relates to the provision of loadable detection molecules with peptide-free MHC molecules utilized for high throughput epitope identification and TCR specificity determination.
    Type: Application
    Filed: September 26, 2019
    Publication date: May 11, 2023
    Inventors: Sine Reker Hadrup, Søren Nyboe Jakobsen, Sunil Kumar Saini
  • SCAFFOLDS WITH STABILIZED MHC MOLECULES FOR IMMUNE-CELL MANIPULATION
    Publication number: 20230138095
    Abstract: The present invention relates to artificial antigen presenting cell (aAPC) scaffolds to provide cells with specific functional stimulation to obtain phenotypic and functional properties ideal to mediate tumor regression or viral clearance. In particular, the scaffolds of the present invention comprise stabilized MHC class I molecules comprising a heavy chain comprising an alpha-1 domain and an alpha-2 domain connected by a disulfide bridge, wherein said MHC class I molecules are free of antigenic peptide. The scaffolds can be loaded with antigenic peptide on demand, providing an agile platform for effective expansion and functional stimulation of specific T cells in a peptide-MHC-directed fashion.
    Type: Application
    Filed: June 19, 2019
    Publication date: May 4, 2023
    Inventors: Sine Reker Hadrup, Søren Nyboe Jakobsen, Sunil Kumar Saini
  • METHOD FOR PRODUCING AN EXAMINATION REAGENT AND KIT FOR ANALYSING A T-CELL FREQUENCY
    Publication number: 20190331681
    Abstract: A method for producing an examination reagent includes adding a helper ligand to a receptor protein which is unfolded in an initial solution so as to provide a pre-solution of the examination reagent with a receptor protein which is folded. The receptor protein which is folded comprises a bonded helper ligand which can be exchanged with an examination peptide.
    Type: Application
    Filed: July 1, 2019
    Publication date: October 31, 2019
    Applicant: JACOBS UNIVERSITY BREMEN GGMBH
    Inventors: SEBASTIAN HARTMUT SPRINGER, SUNIL KUMAR SAINI
  • Method for producing an examination reagent and kit for analysing a T-cell frequency
    Patent number: 10386367
    Abstract: A method for producing an examination reagent includes adding a helper ligand to an unfolded receptor protein in an initial solution so as to provide a pre-solution of the examination reagent with a folded receptor protein. The folded receptor protein comprises a bonded helper ligand which can be exchanged with an examination peptide.
    Type: Grant
    Filed: January 3, 2013
    Date of Patent: August 20, 2019
    Assignee: JACOBS UNIVERSITY BREMEN GGMBH
    Inventors: Sebastian Hartmut Springer, Sunil Kumar Saini
  • METHOD FOR PRODUCING AN EXAMINATION REAGENT AND KIT FOR ANALYSING A T-CELL FREQUENCY
    Publication number: 20140370524
    Abstract: A method for producing an examination reagent includes adding a helper ligand to an unfolded receptor protein in an initial solution so as to provide a pre-solution of the examination reagent with a folded receptor protein. The folded receptor protein comprises a bonded helper ligand which can be exchanged with an examination peptide.
    Type: Application
    Filed: January 3, 2013
    Publication date: December 18, 2014
    Inventors: Sebastien Hartmut Springer, Sunil Kumar Saini