Abstract: A method for producing a coil includes winding a wire in order to produce a wound coil, and stretching the wound coil from an initial state into a stretched state with an increased spread. The method includes providing the wound coil, in the stretched state, with a coating, and transferring the wound coil from the stretched state back into a state of smaller spread.

Abstract: The invention relates to a segmented coil carrier (20; 20?) for an electric machine (2), comprising a plurality of separately formed, interconnected segments (1) with in each case one carrier (10) with a shaft (100) and a coil (11) surrounding the shaft (100), a groove (N) being formed between two adjacent carriers (10); and a groove wedge arranged in the groove (N).

Abstract: Embodiments for creating transactional consistent snapshot copies of SQL server containers in a Kubernetes system for copy reuse on different clusters to facilitate processing local snapshots for secondary workloads without impacting production quality of service. A copy data management (CDM) tool acts as an orchestrator, while a backup toolkit is deployed in the namespace of the production cluster containers. A container storage interface (CSI) plugin supplies persistent storage to the containers. Before taking a copy, the process posts the toolkit in the container and a quiesce/unquiesce operation is then performed. The databases are first quiesced, the snapshot copy is taken, and then the databases are unquiesced. The toolkit is then removed, thus producing a transactional consistent backup in a different namespace.

Abstract: The invention provides implantable drug delivery devices comprising a core comprising a polymer (or polymer blend) and one or more drugs or pharmaceutical substances, and an outer shell comprising a polymer (or polymer blend) and one or more porogen materials. The invention reduces burst release of drug. Pharmaceuticals such as triiodothyronine (T3) or ropinirole can be delivered by the devices.

Abstract: Methods, systems, and apparatus, including computer programs encoded on computer storage media, for generating models. In some implementations, a system obtains data that comprises promotions and parameters for an opportunity. The system generates transformation spaces based on the promotions and the parameters, wherein each transformation space comprises states, each state is based on the parameters for a particular promotion. The system iterates over a number of iterations. For each transformation space, the system adjusts a state of the transformation space based on actions. The system generates a model by combining each adjusted state. The system generates an entropy for the model. The system compares the entropy to a threshold value, wherein the threshold value corresponds to one of the parameters. In response to determining that the entropy exceeds the threshold value, the system iterates. The system provides the generated model for output.

Abstract: The invention provides implantable drug delivery devices comprising a core comprising a polymer (or polymer blend) and one or more drugs or pharmaceutical substances, and an outer shell comprising a polymer (or polymer blend) and one or more porogen materials. The invention reduces burst release of drug. Pharmaceuticals such as triiodothyronine (T3) or ropinirole can be delivered by the devices.

Abstract: Implants are described which comprise lipophilic pharmaceutical substances. Excipients are used which provide appropriate and controllable/tunable release of the lipophilic drug from the matrix of the implant. The implants can be implanted into a patient for release of the pharmaceutical substances. Methods of making and using such implants are also described.

Abstract: The invention provides implantable drug delivery devices comprising a core comprising a polymer (or polymer blend) and one or more drugs or pharmaceutical substances, and an outer shell comprising a polymer (or polymer blend) and one or more porogen materials. The invention reduces burst release of drug. Pharmaceuticals such as triiodothyronine (T3) or ropinirole can be delivered by the devices.

Abstract: The invention provides methods, compositions, and kits for treatment or prevention of biofilm-associated infections in an individual. Methods of the invention include administration of a gallium-containing composition for treatment of an established biofilm or prevention of formation of a biofilm. Some methods include administration of a gallium-containing composition in conjunction with an antibiotic substance. Some methods include treatment or prevention of an orally-associated biofilm with a gallium-containing composition in the form of a dentrifice, mouthwash, or chewing gum composition.

Abstract: The invention provides methods and compositions for treating adverse conditions of the liver in an individual. A pharmaceutical composition including gallium, in the form of a coordination complex of gallium (III), a salt of gallium (III), an inorganic gallium (III) compound other than a gallium salt, or protein-bound gallium (III), together with a pharmaceutically acceptable carrier, is administered to the individual in an amount sufficient to provide a therapeutically or prophylactically effective serum gallium level.

Abstract: An oxyalkylene group containing histone deacetylase(s) inhibitor is used sequentially with another antineoplastic agent to increase antitumor activity in cells and mammals.

Abstract: Methods are provided for the use of gallium in the treatment or prevention of inflammatory arthritis conditions such as rheumatoid arthritis.