Abstract: Methods, systems and devices for detecting the presence of a pathogen, for example, a virus (e.g., SARS-COV-2), or its molecular components, in health care-related samples and/or environmental samples are disclosed. An example system for improving detection of a pathogen includes biosensor device comprising a detection chip and at least one probe that specifically recognizes a pathogen, where the detection chip comprises a graphene field-effect transistor (FET) chip and the probe, which comprises an aptamer, specifically binds to a DNA, RNA, or protein associated with the pathogen.

Abstract: Methods, systems and devices for detecting the presence of a pathogen, for example, a virus (e.g., SARS-CoV-2), or its molecular components, in health care-related samples and/or environmental samples are disclosed. An example system for improving detection of a pathogen includes biosensor device comprising a detection chip and at least one probe that specifically recognizes a pathogen, where the detection chip comprises a graphene field-effect transistor (FET) chip and the probe, which comprises an aptamer, specifically binds to a DNA, RNA, or protein associated with the pathogen.

Abstract: A system for creating thrust for flying machines with Vertical Take Off and Landing (VTOL) including a first propulsion unit, a second propulsion unit, a top winget, a bottom winget, two or more tracks running over said first and second propulsion units, and wherein the two or more tracks are configured to mount said top and bottom wingets.

Abstract: Systems and methods are provided for evaluating an eye using retinal fluid volumes to provide a clinical parameter. An optical coherence tomography (OCT) image of an eye of a patient is obtained. The OCT image is segmented to produce a total retinal volume and one or both of a subretinal fluid volume and an intraretinal fluid volume for a region of interest within the eye. A metric is generated as a function of the total retinal volume and one or both of the subretinal fluid volume and the intraretinal fluid volume. A clinical parameter for the patient is determined from the metric. The determined clinical parameter is provided to a user at a display.

Abstract: Methods, systems and devices for detecting the presence of a pathogen, for example, a virus (e.g., SARS-CoV-2), or its molecular components, in health care-related samples and/or environmental samples are disclosed. An example system for improving detection of a pathogen includes biosensor device comprising a detection chip and at least one probe that specifically recognizes a pathogen, where the detection chip comprises a graphene field-effect transistor (FET) chip and the probe, which comprises an aptamer, specifically binds to a DNA, RNA, or protein associated with the pathogen.

Abstract: Embodiments facilitate prediction of anti-vascular endothelial growth (anti-VEGF) therapy response in DME or RVO patients. A first set of embodiments discussed herein relates to training of a machine learning classifier to determine a prediction for response to anti-VEGF therapy based on a vascular network organization via Hough transform (VaNgOGH) descriptor generated based on FA images of tissue demonstrating DME or RVO. A second set of embodiments discussed herein relates to determination of a prediction of response to anti-VEGF therapy for a DME or RVO patient (e.g., non-rebounder vs. rebounder, response vs. non-response) based on a VaNgOGH descriptor generated based on FA imagery of the patient.

Abstract: Embodiments facilitate prediction of anti-vascular endothelial growth (anti-VEGF) therapy response in DME patients. A first set of embodiments discussed herein relates to training of a machine learning classifier to determine a prediction for response to anti-VEGF therapy based on a set of graph-network features and a set of morphological features generated based on FA images of tissue demonstrating DME. A second set of embodiments discussed herein relates to determination of a prediction of response to anti-VEGF therapy for a DME patient (e.g., non-rebounder vs. rebounder, response vs. non-response) based on a set of graph-network features and a set of morphological features generated based on FA imagery of the patient.

Abstract: Systems and methods are provided for evaluating an eye using retinal fluid volumes to provide a clinical parameter. An optical coherence tomography (OCT) image of an eye of a patient is obtained. The OCT image is segmented to produce a total retinal volume and one or both of a subretinal fluid volume and an intraretinal fluid volume for a region of interest within the eye. A metric is generated as a function of the total retinal volume and one or both of the subretinal fluid volume and the intraretinal fluid volume. A clinical parameter for the patient is determined from the metric. The determined clinical parameter is provided to a user at a display.

Abstract: Systems and methods are provided for evaluating an eye of a patient from a set of OCT data. A layer segmentation component is configured to identify and segment a plurality of retinal layers within the set of OCT data. The plurality of layers include a layer of interest. A mapping component is configured to generate at least one of an en face representation of the layer of interest and a three-dimensional reconstruction of the layer of interest from the segmented plurality of layers. A parameter generator is configured to derive at least one parameter, representing a thickness of the layer of interest, from the at least one of the en face representation of the layer of interest and the three-dimensional reconstruction of the layer of interest. A user interface is configured to provide the determined at least one parameter to a display.

Abstract: Systems and methods are provided for evaluating an eye of a patient. A first imager interface receives a first image of at least a portion of the eye generated via a first imaging modality, and a second imager interface receives a second image of at least a portion of the eye generated via a second imaging modality. A first feature extractor extracts a first set of numerical features from the first image, with one feature representing a spatial extent of one of a tissue layer, a tissue structure, and a pathological feature. A second feature extractor extracts a second set of numerical features from the second image, with one feature representing one of a number and a location of vascular irregularities within the eye. A pattern recognition component evaluates the first plurality of features and the second plurality of features to assign a clinical parameter to the eye.

Abstract: Systems and methods are provided for evaluating an eye of a patient. A first imager interface receives a first image of at least a portion of the eye generated via a first imaging modality, and a second imager interface receives a second image of at least a portion of the eye generated via a second imaging modality. A first feature extractor extracts a first set of numerical features from the first image, with one feature representing a spatial extent of one of a tissue layer, a tissue structure, and a pathological feature. A second feature extractor extracts a second set of numerical features from the second image, with one feature representing one of a number and a location of vascular irregularities within the eye. A pattern recognition component evaluates the first plurality of features and the second plurality of features to assign a clinical parameter to the eye.

Abstract: Systems and methods are provided for evaluating an eye of a patient from a set of OCT data. A layer segmentation component is configured to identify and segment a plurality of retinal layers within the set of OCT data. The plurality of layers include a layer of interest. A mapping component is configured to generate at least one of an en face representation of the layer of interest and a three-dimensional reconstruction of the layer of interest from the segmented plurality of layers. A parameter generator is configured to derive at least one parameter, representing a thickness of the layer of interest, from the at least one of the en face representation of the layer of interest and the three-dimensional reconstruction of the layer of interest. A user interface is configured to provide the determined at least one parameter to a display.

Abstract: An apparatus and method for using nanostructures, such as nanopores, nanofibers, nanowells, or nanocones as carriers for drugs, biomarkers and/or biomolecules. The apparatus and method for use on implant surfaces to retain and release drugs, biomarkers and/or biomolecules on command by an external stimulus.

Abstract: An approach for establishing secure communication among multiple multicast groups using a multi-master directory is disclosed. The multi-master directory is on a per object and per attribute access controls basis. The event service nodes, which can implemented as event servers, are distributed throughout an enterprise domain. The attributes of the event service nodes include the group session key and the private keys of the event service nodes. A standardized authentication service is used to register publishers and subscribers. These publishers and subscribers can individually belong to multiple multicast groups under a readily scalable, secure network architecture.

Abstract: An approach for establishing secure multicast communication among multiple multicast proxy service nodes is disclosed. The multicast proxy service nodes, which can be distributed throughout an enterprise domain, are organized in a logical tree that mimics the logical tree arrangement of domains in a directory server system. The attributes of the multicast proxy service nodes include the group session keys that are members of the secure multicast or broadcast groups. Because keys as well as key version information are housed in the directory, multicast security can be achieved over any number of network domains across the entire enterprise. Key information is stored in, and the logical tree is supported by, a directory service. Replication of the directory accomplishes distribution of keys. Multicast proxy service nodes may obtain current key information from a local copy of the replicated directory.

Abstract: A router for routing data from a client through load-balancing nodes to a selected load-balanced server among a plurality of servers in a network involves: receiving, at a last load balancing node associated with a selected server among the plurality of servers, a first packet of a server reply to a request from the client; storing identifiers of ingress interfaces on which the packet arrives, in a send path list for server load balancing, as the first packet of the server reply is routed from the last load balancing node to the client using hop-by-hop decisions; receiving subsequent packets of the client request; and forwarding the subsequent packets to the selected server only on a route that is defined by the send path list and without hop-by-hop routing decisions. Packet flows are routed from the same client to the same server without hop-by-hop routing decisions or repeated load-balancing decisions.

Abstract: An approach for establishing secure multicast communication among multiple multicast proxy service nodes is disclosed. The multicast proxy service nodes, which can be distributed throughout an enterprise domain, are organized in a logical tree that mimics the logical tree arrangement of domains in a directory server system. The attributes of the multicast proxy service nodes include the group session key and the private keys of the multicast proxy service nodes that are members of the multicast or broadcast groups. The private keys provide unique identification values for the multicast proxy service nodes, thereby facilitating distribution of such keys. Because keys as well as key version information are housed in the directory, multicast security can be achieved over any number of network domains across the entire enterprise. Key information is stored in, and the logical tree is supported by, a directory service. Replication of the directory accomplishes distribution of keys.

Abstract: This invention relates to the purification of sucralose by contacting a mixture containing crude sucralose with organic and/or aqueous organic solvents. The mixture may be crystallized from aqueous organic solvents using pure sucralose seed crystals.

Abstract: An approach for establishing secure communication among multiple multicast groups using a multi-master directory is disclosed. The multi-master directory is on a per object and per attribute access controls basis. The event service nodes, which can implemented as event servers, are distributed throughout an enterprise domain. The attributes of the event service nodes include the group session key and the private keys of the event service nodes. A standardized authentication service is used to register publishers and subscribers. These publishers and subscribers can individually belong to multiple multicast groups under a readily scalable, secure network architecture.

Abstract: A method of routing data from a client through one or more load-balancing routers to a selected load-balanced server among a plurality of servers in a network involves: receiving, at a load balancing node in a path from the client to the plurality of servers, a first packet of a request from a client; creating and storing a mapping of flow identifying information, associated with the first packet, to a client stickiness identifier; pushing the client stickiness label into a sending path list that is stored in association with the first packet; storing the client stickiness label in a mapping of client stickiness labels to server identifiers at a last load balancing node associated with the plurality of servers, wherein the mapping associates the client stickiness label with a server identifier that uniquely identifies a selected server that has been selected from among the plurality of servers to receive the client request; and forwarding all subsequent packets associated with the client request to the same s