Abstract: A sodium-ion pouch cell belongs to the technical field of new energy materials and devices. The pouch cell and comprises a cathode piece, a diaphragm, a presodiated anode piece, an electrolyte, a tab and an aluminum plastic film package, and is obtained by sequentially laminating 1 to 30 cathode pieces and 2 to 31 presodiated anode pieces in a Z-shaped manner, adding the electrolyte and packaging, the sodium-ion pouch cell is characterized in that: the cathode piece contains an O3 layered oxide cathode material, a chemical formula is NaaNibZncFedMneTi(1-b-c-d-e)O2, 0.8?a?1, 0.2<b?0.5, 0<c?0.1, 0<d?0.2, 0.2<e?0.5, the presodiated anode piece contains a hard carbon anode material, and a double-sided density of the cathode piece is 28 mg/cm2 to 33 mg/cm2; and a double-sided density of the anode piece is 14 mg/cm2 to 16 mg/cm2, and a battery capacity is 0.1 Ah to 10 Ah.

Abstract: The present invention provides use of Tadalafil as a protein arginine methyltransferase 5 (PRMT5) inhibitor. The present invention finds out that Tadalafil is a PRMT5 inhibitor by virtually screening active compounds targeting PRMT5 based on crystal structure and information about active sites of PRMT5. The present invention not only confirms that Tadalafil can inhibit an enzymatic activity of PRMT5, but also confirms that Tadalafil alone can inhibit tumor growth in breast cancer and improve sensitivity to chemotherapy for breast cancer.

Abstract: The present invention provides use of Tadalafil as a protein arginine methyltransferase 5 (PRMT5) inhibitor. The present invention finds out that Tadalafil is a PRMT5 inhibitor by virtually screening active compounds targeting PRMT5 based on crystal structure and information about active sites of PRMT5. The present invention not only confirms that Tadalafil can inhibit an enzymatic activity of PRMT5, but also confirms that Tadalafil alone can inhibit tumor growth in breast cancer and improve sensitivity to chemotherapy for breast cancer.