Patents by Inventor Sunita Chaudhary
Sunita Chaudhary has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 8722384Abstract: The present invention relates to fatty acid desaturases able to catalyze the conversion of oleic acid to linoleic acid, linoleic acid to ?-linolenic acid, or of alpha-linolenic acid to stearidonic acid. Nucleic acid sequences encoding desaturases, nucleic acid sequences which hybridize thereto, DNA constructs comprising a desaturase gene, and recombinant host microorganism or animal expressing increased levels of a desaturase are described. Methods for desaturating a fatty acid and for producing a desaturated fatty acid by expressing increased levels of a desaturase are disclosed. Fatty acids, and oils containing them, which have been desaturated by a desaturase produced by recombinant host microorganisms or animals are provided. Pharmaceutical compositions, infant formulas or dietary supplements containing fatty acids which have been desaturated by a desaturase produced by a recombinant host microorganism or animal also are described.Type: GrantFiled: March 30, 2009Date of Patent: May 13, 2014Assignees: Calgene LLC, Abbott LaboratoriesInventors: Deborah Knutzon, Pradip Mukerji, Yung-Sheng Huang, Jennifer Thurmond, Sunita Chaudhary, Amanda Eun-Yeong Leonard
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Publication number: 20110256260Abstract: The present invention relates to fatty acid desaturases able to catalyze the conversion of oleic acid linoleic acid, linoleic acid to ?-linolenic acid, or of alpha-linolenic acid to stearidonic acid. Nucleic acid sequences encoding desaturases, nucleic acid sequences which hybridize thereto, DNA constructs comprising a desaturase gene, and recombinant host microorganism or animal expressing increased levels of a desaturase are described. Methods for desaturating a fatty acid and for producing a desaturated fatty acid by expressing increased levels of a desaturase are disclosed. Fatty acids, and oils containing them, which have been desaturated by a desaturase produced by recombinant host microorganisms or animals are provided. Pharmaceutical compositions, infant formulas or dietary supplements containing fatty acids which have been desaturated by a desaturase produced by a recombinant host microorganism or animal also are described.Type: ApplicationFiled: March 30, 2009Publication date: October 20, 2011Applicants: Calgene LLC, Abbott LaboratoriesInventors: Deborah Knutzon, Pradip Mukerji, Yung-Sheng Huang, Jennifer Thurmond, Sunita Chaudhary, Amanda Leonard
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Publication number: 20100310710Abstract: The present invention relates to fatty acid desaturases able to catalyze the conversion of oleic acid linoleic acid, linoleic acid to ?-linolenic acid, or of alpha-linolenic acid to stearidonic acid. Nucleic acid sequences encoding desaturases, nucleic acid sequences which hybridize thereto, DNA constructs comprising a desaturase gene, and recombinant host microorganism or animal expressing increased levels of a desaturase are described. Methods for desaturating a fatty acid and for producing a desaturated fatty acid by expressing increased levels of a desaturase are disclosed. Fatty acids, and oils containing them, which have been desaturated by a desaturase produced by recombinant host microorganisms or animals are provided. Pharmaceutical compositions, infant formulas or dietary supplements containing fatty acids which have been desaturated by a desaturase produced by a recombinant host microorganism or animal also are described.Type: ApplicationFiled: March 30, 2009Publication date: December 9, 2010Applicant: MONSANTO TECHNOLOGY LLCInventors: Deborah Knutzon, Pradip Mukerji, Yung-Sheng Huang, Jennifer Thurmond, Sunita Chaudhary, Amanda Eun-Yeong Leonard
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Patent number: 7745694Abstract: The present invention relates to compositions and methods for preparing polyunsaturated long chain fatty acids in plants, plant parts and plant cells, such as leaves, roots, fruits and seeds. Nucleic acid sequences and constructs encoding fatty acid desaturases, including ?5-desaturases, ?6-desaturases and ?12-desaturases, are used to generate transgenic plants, plant parts and cells which contain and express one or more transgenes encoding one or more desaturases. Expression of the desaturases with different substrate specificities in the plant system permit the large scale production of polyunsaturated long chain fatty acids such as docosahexaenoic acid, eicosapentaenoic acid, ?-linolenic acid, gamma-linolenic acid, arachidonic acid and the like for modification of the fatty acid profile of plants, plant parts and tissues. Manipulation of the fatty acid profiles allows for the production of commercial quantities of novel plant oils and products.Type: GrantFiled: April 10, 1998Date of Patent: June 29, 2010Assignee: Monsanto Technology LLCInventors: Deborah Knutzon, Pradip Mukerji, Yung-Sheng Huang, Jennifer Thurmond, Sunita Chaudhary, Amanda Eun-Yeong Leonard
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Patent number: 7531347Abstract: The present invention relates to fatty acid desaturases able to catalyze the conversion of oleic acid to linoleic acid, linoleic acid to ?-linolenic acid, or of alpha-linolenic acid to stearidonic acid. Nucleic acid sequences encoding desaturases, nucleic acid sequences which hybridize thereto, DNA constructs comprising a desaturase gene, and recombinant host microorganism or animal expressing increased levels of a desaturase are described. Methods for desaturating a fatty acid and for producing a desaturated fatty acid by expressing increased levels of a desaturase are disclosed. Fatty acids, and oils containing them, which have been desaturated by a desaturase produced by recombinant host microorganisms or animals are provided. Pharmaceutical compositions, infant formulas or dietary supplements containing fatty acids which have been desaturated by a desaturase produced by a recombinant host microorganism or animal also are described.Type: GrantFiled: April 10, 1998Date of Patent: May 12, 2009Assignees: Abbott Laboratories, Calgene, LLCInventors: Deborah Knutzon, Pradip Mukerji, Yung-Sheng Huang, Jennifer Thurmond, Sunita Chaudhary, Amanda Eun-Yeong Leonard
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Patent number: 6589767Abstract: The present invention relates to a fatty acid &Dgr;5-desaturase able to catalyze the conversion of dihomo-gamma-linolenic acid to arachidonic acid. Nucleic acid sequences encoding a &Dgr;5-desaturase, nucleic acid sequences which hybridize thereto, DNA constructs comprising a &Dgr;5-desaturase gene, and recombinant host microorganism or animal expressing increased levels of a &Dgr;5-desaturase are described. Methods for desaturating a fatty acid at the &Dgr;5 position and for producing arachidonic acid by expressing increased levels of a &Dgr;5 desaturase are disclosed. Fatty acids, and oils containing them, which have been desaturated by a &Dgr;5-desaturase produced by recombinant host microorganisms or animals are provided. Pharmaceutical compositions, infant formulas or dietary supplements containing fatty acids which have been desaturated by a &Dgr;5-desaturase produced by a recombinant host microorganism or animal also are described.Type: GrantFiled: August 19, 1999Date of Patent: July 8, 2003Assignees: Abbott Laboratories, Calgene, LLCInventors: Deborah Knutzon, Pradip Mukerji, Yung-Sheng Huang, Jennifer Thurmond, Sunita Chaudhary
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Patent number: 6410288Abstract: The present invention relates to fatty acid desaturases able to catalyze the conversion of oleic acid to linoleic acid, linoleic acid to gamma-linolenic acid, or of alpha-linolenic acid to stearidonic acid. Nucleic acid sequences encoding desaturases, nucleic acid sequences which hybridize thereto, DNA constructs comprising a desaturase gene, and recombinant host microorganism or animal expressing increased levels of a desaturase are described. Methods for desaturating a fatty acid and for producing a desaturated fatty acid by expressing increased levels of a desaturase are disclosed. Fatty acids, and oils containing them, which have been desaturated by a desaturase produced by recombinant host microorganisms or animals are provided. Pharmaceutical compositions, infant formulas or dietary supplements containing fatty acids which have been desaturated by a desaturase produced by a recombinant host microorganism or animal also are described.Type: GrantFiled: July 29, 1999Date of Patent: June 25, 2002Assignees: Calgene, Inc., Abbott LaboratoriesInventors: Deborah Knutzon, Pradip Mukerji, Yung-Sheng Huang, Jennifer Thurmond, Sunita Chaudhary
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Patent number: 6287866Abstract: The subject invention relates to &bgr;-casein expressing constructs which have significant stability when introduced into host cells. These constructs, for purposes of the present invention, have been designated as pRAB-84-69 and pRSB-14. Each construct comprises an isolated DNA sequence comprising i) a nucleotide sequence encoding a protein, wherein said nucleotide sequence is operably linked to a promoter, ii) a nucleotide sequence encoding a first subunit of a kinase, iii) a nucleotide sequence encoding a second subunit of a kinase, iv) a nucleotide encoding a peptidase and v) a nucleotide sequence encoding a bacterial resistance marker. These constructs, once introduced into a host cell, may be used in the production of, for example, recombinant human beta-casein.Type: GrantFiled: August 7, 1998Date of Patent: September 11, 2001Assignee: Abbott LaboratoriesInventors: Pradip Mukerji, Steven A. Lemmel, Amanda Eun-Yeong Leonard, Sunita Chaudhary
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Patent number: 6136574Abstract: The present invention relates to fatty acid desaturases able to catalyze the conversion of oleic acid to linoleic acid, linoleic acid to gamma-linolenic acid, or of alpha-linolenic acid to stearidonic acid. Nucleic acid sequences encoding desaturases, nucleic acid sequences which hybridize thereto, DNA constructs comprising a desaturase gene, and recombinant host microorganism or animal expressing increased levels of a desaturase are described. Methods for desaturating a fatty acid and for producing a desaturated fatty acid by expressing increased levels of a desaturase are disclosed. Fatty acids, and oils containing them, which have been desaturated by a desaturase produced by recombinant host microorganisms or animals are provided. Pharmaceutical compositions, infant formulas or dietary supplements containing fatty acids which have been desaturated by a desaturase produced by a recombinant host microorganism or animal also are described.Type: GrantFiled: July 29, 1999Date of Patent: October 24, 2000Assignees: Abbott Laboratories, Calgene LLCInventors: Deborah Knutzon, Pradip Mukerji, Yung-Sheng Huang, Jennifer Thurmond, Sunita Chaudhary
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Patent number: 6075183Abstract: The present invention relates to compositions and methods for preparing poly-unsaturated long chain fatty acids in plants, plant parts and plant cells, such as leaves, roots, fruits and seeds. Nucleic acid sequences and constructs encoding fatty acid desaturases, including .DELTA.5-desaturases, .DELTA.6-desaturases and .DELTA.12-desaturases, are used to generate transgenic plants, plant parts and cells which contain and express one or more transgenes encoding one or more desaturases. Expression of the desaturases with different substrate specificities in the plant system permit the large scale production of poly-unsaturated long chain fatty acids such as docosahexaenoic acid, eicosapentaenoic acid, .alpha.-linoleic acid, gamma-linolenic acid, arachidonic acid and the like for modification of the fatty acid profile of plants, plant parts and tissues. Manipulation of the fatty acid profiles allows for the production of commercial quantities of novel plant oils and products.Type: GrantFiled: April 11, 1997Date of Patent: June 13, 2000Assignees: Abbott Laboratories, Calgene LLCInventors: Deborah Knutzon, Pradip Mukerji, Yung-Sheng Huang, Jennifer Thurmond, Sunita Chaudhary
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Patent number: 5972664Abstract: The present invention relates to a fatty acid .DELTA.5-desaturase able to catalyze the conversion of dihomo-gamma-linolenic acid to arachidonic acid. Nucleic acid sequences encoding a .DELTA.5-desaturase, nucleic acid sequences which hybridize thereto, DNA constructs comprising a .DELTA.5-desaturase gene, and recombinant host microorganism or animal expressing increased levels of a .DELTA.5-desaturase are described. Methods for desaturating a fatty acid at the .DELTA.5 position and for producing arachidonic acid by expressing increased levels of a .DELTA.5 desaturase are disclosed. Fatty acids, and oils containing them, which have been desaturated by a .DELTA.5-desaturase produced by recombinant host microorganisms or animals are provided. Pharmaceutical compositions, infant formulas or dietary supplements containing fatty acids which have been desaturated by a .DELTA.5-desaturase produced by a recombinant host microorganism or animal also are described.Type: GrantFiled: April 11, 1997Date of Patent: October 26, 1999Assignees: Abbott Laboratories, Calgene, Inc.Inventors: Deborah Knutzon, Pradip Mukerji, Yung-Sheng Huang, Jennifer Thurmond, Sunita Chaudhary
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Patent number: 5968809Abstract: The present invention relates to fatty acid desaturases able to catalyze the conversion of oleic acid to linoleic acid, linoleic acid to gamma-linolenic acid, or of alpha-linolenic acid to stearidonic acid. Nucleic acid sequences encoding desaturases, nucleic acid sequences which hybridize thereto, DNA constructs comprising a desaturase gene, and recombinant host microorganism or animal expressing increased levels of a desaturase are described. Methods for desaturating a fatty acid and for producing a desaturated fatty acid by expressing increased levels of a desaturase are disclosed. Fatty acids, and oils containing them, which have been desaturated by a desaturase produced by recombinant host microorganisms or animals are provided. Pharmaceutical compositions, infant formulas or dietary supplements containing fatty acids which have been desaturated by a desaturase produced by a recombinant host microorganism or animal also are described.Type: GrantFiled: April 11, 1997Date of Patent: October 19, 1999Assignees: Abbot Laboratories, Calgene Inc.Inventors: Deborah Knutzon, Pradip Mukerji, Yung-Sheng Huang, Jennifer Thurmond, Sunita Chaudhary