Abstract: The present invention provides a combination of PDE4 inhibitors or pharmaceutically acceptable salts thereof along with at least one secondary therapeutic agent. The present invention also provides process for the preparation of topical pharmaceutical composition of said combination with one or more pharmaceutically acceptable excipients. The present invention further relates to use of topical pharmaceutical composition for the treatment of atopic dermatitis.

Abstract: Determining when to perform preventative maintenance is an important consideration for maximizing the revenue of a wind turbine. For example, performing preventative maintenance may be cheaper than replacing turbine components when they fail. When determining to perform preventative maintenance, a maintenance scheduler may consider multiple factors. These factors may include the probability of failure, the predicted price of energy, predicted wind power production, resource constraints, and the like. Specifically, the maintenance scheduler may predict the future values of these factors which are then integrated into a net present value (NPV) for each of the components. Based on the respective NPVs, the maintenance scheduler may determine which maintenance actions to perform and in what order.

Abstract: Method, power plant, and computer program product for use in controlling power output by a power plant. The power plant includes a wind farm with a plurality of wind turbines, a grid power converter (such as one or more HVDC links), a sensor to measure the frequency of a power grid, and a supervisory controller. The supervisory controller implements a control algorithm that adjusts the power output from the power plant in response to the frequency of the power grid dropping below a first target frequency by changing the pitch of the blades of at least one wind turbine, increasing the level of a portion of the power contributed by at least one wind turbine, or increasing the level of the power output by the grid power converter.

Abstract: Method, power plant, and computer program product for use in controlling power output by a power plant. The power plant includes a wind farm with a plurality of wind turbines, a grid power converter (such as one or more HVDC links), a sensor to measure the frequency of a power grid, and a supervisory controller. The supervisory controller implements a control algorithm that adjusts the power output from the power plant in response to the frequency of the power grid dropping below a first target frequency by changing the pitch of the blades of at least one wind turbine, increasing the level of a portion of the power contributed by at least one wind turbine, or increasing the level of the power output by the grid power converter.

Abstract: A wind power plant comprising a plurality of wind turbine converters coupled to a High Voltage Direct Current (HVDC) converter via an internal grid and a power plant controller. The power plant controller is configured to monitor a voltage of the internal grid, and allocate responsibility for generating reactive power to the HVDC converter and the wind turbine converters to maintain the voltage of the internal grid at a desired voltage.

Abstract: A wind power plant comprising a plurality of wind turbine converters coupled to a High Voltage Direct Current (HVDC) converter via an internal grid and a power plant controller. The power plant controller is configured to monitor a voltage of the internal grid, and allocate responsibility for generating reactive power to the HVDC converter and the wind turbine converters to maintain the voltage of the internal grid at a desired voltage.

Abstract: A contaminated aqueous composition is withdrawn from a groundwater extraction well and the groundwater is treated in a pump and treat system to remove a contaminant. The treating of the aqueous composition is monitored from a location remote from the groundwater extraction well and the treating is adjusted to remove a contaminant in accordance with the monitoring. A system to treat a contaminated aqueous composition comprises a capture zone to intercept a contaminated aqueous composition and a surface pump and treat system to receive and treat the contaminated aqueous composition from the capture zone. The system also includes a sensor that senses a contaminant in the contaminated aqueous composition and a monitor to receive information concerning the contaminant from the sensor and to consequently control the pump and treat system to treat the contaminated aqueous composition. The monitor is situated at a location remote from the pump and treat system.

Abstract: An on-line sparging sampling system and method sparges polar and non-polar volatile organic compounds from aqueous discharge. The system comprises a network of tubular members that are interconnected to each other to define a fluid passage, in which the network of tubular members comprises an inlet for influent aqueous discharge into the network of tubular members and an outlet for discharge of aqueous discharge from the on-line sparging sampling and monitoring system; a sparger disposed in the network of tubular members, in which the sparger is disposed between the inlet and the outlet of the aqueous discharge so that aqueous discharge flows by the sparger, the sparger providing inert non-reactive gas to the on-line sparging sampling and monitoring system; and at least one analytic device connected to the on-line sparging sampling and monitoring system for analyzing volatile organic compounds in the aqueous discharge.

Abstract: In a method for treating a contaminated fluid stream, a characteristic of a flow of the composition to a carbon adsorption zone is sensed. The sensing is remotely monitored to determine a treatment for the contaminated fluid stream. The contaminated fluid stream is then treated according to the monitoring. A system for treating a contaminated fluid stream comprises a sensor that senses a characteristic of a flow of a contaminated fluid stream prior to treatment and a monitor to receive information concerning the characteristic from the sensor and to consequently control the carbon adsorption zone to treat the contaminated fluid stream. The monitor is situated at a location remote from the carbon adsorption zone.

Abstract: A headspace sampling system monitors materials in wastewater. The headspace sampling system comprises a sample receptacle that can contain a wastewater sample; a sparger chamber vapor column; a sample receptacle cover assembly that connects the sparger chamber vapor column to the sample receptacle; a sparger tube; at least one sensing device; and at least one analytic device. The sparger tube and the sample receptacle define a headspace. The sparger chamber vapor column is in communication with the sample receptacle and is closed by a sparger chamber vapor column cover at a second end that is opposed to the sample receptacle. The sparger tube extends into the sample receptacle and the wastewater sample in the sample receptacle. The sparger tube is connected to a source of inert gas at a first end opposed to the sample receptacle and comprises a dispersion device at an end opposed to the first end. The sensing device is disposed in the headspace sampling system in the headspace.

Abstract: A sampling device can monitor contaminants in groundwater. The sampling device comprises a semi-permeable membrane for contact with groundwater, in which the semi-permeable membrane is permeable to contaminants and impermeable to groundwater; an inner chamber formed by the semi-permeable membrane for containing the contaminants from the groundwater that diffuse through the semi-permeable membrane; and a sensor device communicating with the inner chamber. The sensor device is in contact with the contaminants contained within the inner chamber for monitoring the contaminants.

Abstract: A process for making bis(ether anhydrides) employs alkylamines having low melting temperatures thus allowing for novel intermediate process steps for preparing bis(ether anhydrides). The alkylamines have alkyl groups which contain at least three carbon atoms and have boiling temperatures in the range of 48 to 250.degree. C. at atmospheric pressure. As a result of using these amines, liquid alkylamines now can be employed in the imidization process step. The N-alkyl nitrophthalimides prepared from the recovered imidization product according to this invention can now be purified using liquid/liquid extraction or vacuum distillation. The alkyl nitrophthalimides prepared according to this invention provide for displacement reactions which now can be run at a high solids level. Likewise, the exchange reaction can be run at a higher solids level, and thus achieves an efficiency level which is higher than conventional processes.

Abstract: An improved method and apparatus for monitoring the concentration of contaminants, including volatile organic compounds, in groundwater is provided comprising a semipermeable membrane defining an inner chamber. The chamber is carried within a mesh protective sleeve of cover to prevent abrasion or puncture of the chamber. The membrane is permeable to contaminants but impermeable to a reference fluid, which is distilled water. The method of sampling comprises placing the semipermeable membrane chamber, which contains the reference fluid, in contact with contaminated groundwater, thereby allowing contaminants to diffuse through the semipermeable membrane.

Abstract: A process for making bis(ether anhydrides) employs alkylamines having low melting temperatures thus allowing for novel intermediate process steps for preparing bis(ether anhydrides). The alkylamines have alkyl groups which contain at least three carbon atoms and have boiling temperatures in the range of 48 to 250.degree. C. at atmospheric pressure. As a result of using these amines, liquid alkylamines now can be employed in the imidization process step. The N-alkyl nitrophthalimides prepared from the recovered imidization product according to this invention can now be purified using liquid/liquid extraction or vacuum distillation. The alkyl nitrophthalimides prepared according to this invention provide for displacement reactions which now can be run at a high solids level. Likewise, the exchange reaction can be run at a higher solids level, and thus achieves an efficiency level which is higher than conventional processes.

Abstract: The instant invention relates to a novel process for the hydrolysis of the by-products produced during the manufacture of methyldichlorosilanes comprising combining the by-products with an aqueous medium, optionally comprising a surfactant, at a pH range of at least about 7 and at a temperature of above about 0.degree. C. to produce a solid material in which copper and other metals are retained in a solid phase thereby resulting in a product with a high copper content.

Abstract: A process for making bis(ether anhydrides) employs alkylamines having low melting temperatures thus allowing for novel intermediate process steps for preparing bis(ether anhydrides). The alkylamines have alkyl groups which contain at least three carbon atoms and have boiling temperatures in the range of 48.degree. to 250.degree. C. at atmospheric pressure. As a result of using these amines, liquid alkylamines now can be employed in the imidization process step. The N-alkyl nitrophthalimides prepared from the recovered imidization product according to this invention can now be purified using liquid/liquid extraction or vacuum distillation. The alkyl nitrophthalimides prepared according to this invention provide for displacement reactions which now can be run at a high solids level. Likewise, the exchange reaction can be run at a higher solids level, and thus achieves an efficiency level which is higher than conventional processes.

Abstract: Reactions between a solid polar and a non-polar compound, especially nucleophilic aromatic substitution reactions between an alkali metal salt of a hydroxyaromatic compound or thio analog thereof and an activated halo- or nitro-substituted aromatic compound, are conducted in a non-polar organic solvent such as toluene or xylene, in the presence of a hexaalkylguanidinium or .alpha.,.omega.-bis(pentaalkylguanidinium)alkane salt, or a corresponding heterocyclic salt, as a phase transfer catalyst. The method is particularly useful for the preparation of bisimides from bisphenol A or 4,4'-biphenol salts and 4-nitro- or 4-halophthalimides.