Abstract: The present invention relates to a novel heterocyclic compound and a composition, for preventing or treating a cancer, an autoimmune disease, and an inflammatory disease, comprising same. The novel heterocyclic compound of the present invention is a bifunctional compound having a Bruton's tyrosine kinase (BTK) degradation function via a ubiquitin proteasome pathway, and may be utilized as a composition for preventing or treating a cancer, an autoimmune disease, and Parkinson's disease.

Abstract: The present invention relates to a novel heterocyclic compound and a composition, for preventing or treating a cancer, an autoimmune disease, and an inflammatory disease, comprising same. The novel heterocyclic compound of the present invention is a bifunctional compound having a Bruton's tyrosine kinase (BTK) degradation function via a ubiquitin proteasome pathway, and may be utilized as a composition for preventing or treating a cancer, an autoimmune disease, and Parkinson's disease.

Abstract: A semiconductor memory device, and a method of manufacturing the same, includes a lower stack in which a plurality of first interlayer insulating layers and first conductive layers are alternately stacked, a plurality of cell plugs passing through the lower stack in a vertical direction, an upper stack in which a plurality of second interlayer insulating layers and at least one second conductive layer are alternately stacked on the lower stack, a plurality of drain select plugs passing through the upper stack and being in contact with an upper portion of the plurality of cell plugs, and a separation pattern separating adjacent drain select plugs among the plurality of drain select plugs, wherein the separation pattern is in contact with a sidewall of each of the adjacent drain select plugs.

Abstract: A multilayer electronic component includes a body including a capacitance formation portion including a dielectric layer and an internal electrode, alternately disposed in a first direction, and a cover portion disposed on both end surfaces of the capacitance formation portion opposing each other in the first direction; and an external electrode disposed outside the body and connected to the internal electrode, wherein the cover portion contains fluorine (F), and A1 and A2 satisfy A2>A1, where A1 is an average size of a dielectric grain included in the cover portion, and A2 is an average size of a dielectric grain included in the dielectric layer.

Abstract: A semiconductor memory device, and a method of manufacturing the same, includes a lower stack in which a plurality of first interlayer insulating layers and first conductive layers are alternately stacked, a plurality of cell plugs passing through the lower stack in a vertical direction, an upper stack in which a plurality of second interlayer insulating layers and at least one second conductive layer are alternately stacked on the lower stack, a plurality of drain select plugs passing through the upper stack and being in contact with an upper portion of the plurality of cell plugs, and a separation pattern separating adjacent drain select plugs among the plurality of drain select plugs, wherein the separation pattern is in contact with a sidewall of each of the adjacent drain select plugs.

Abstract: A multilayer electronic component includes a body including a capacitance formation portion including a dielectric layer and internal electrodes alternately disposed in a first direction, and a cover portion disposed on both surfaces of the capacitance formation portion opposing each other in the first direction; and an external electrode disposed on the body and connected to the internal electrode, wherein the cover portion includes polydopamine.

Abstract: An electronic device and a method of measuring an amount of user physical activity by an electronic device are provided. The method includes establishing short range communication among a plurality of electronic devices, determining one of the plurality of electronic devices as a primary device, communicating state information of remaining electronic devices to the primary device, activating a sensor on a device having a highest priority among the plurality of electronic devices according to the state information, recording physical activity information according to physical activity sensed by the sensor, communicating the physical activity information to the primary device, calculating an amount of physical activity according to the communicated physical activity information, and synchronizing the amount of physical activity among the plurality of electronic devices.

Abstract: Liquid-crystalline (LC) media having positive dielectric anisotropy and liquid-crystal displays (LCDs) containing these media, especially displays addressed by an active matrix and in particular energy saving LC displays of the TN, PS-TN, STN, TN-TFT, OCB, IPS, PS-IPS, FFS, HB-FFS, XB-FFS, PS-FFS, SA-HB-FFS, SA-XB-FFS, polymer stabilised SA-HB-FFS, polymer stabilised SA-XB-FFS, positive VA or positive PS-VA type. The media have an improved long-term stability against UV radiation and elevated temperatures.

Abstract: The present invention relates to treatment of dry eye syndrome using a tanfanercept-containing ophthalmic composition. According to the present invention, as a result of clinical trial on dry eye syndrome, the tanfanercept-containing ophthalmic composition demonstrated excellent effects with regard to improvement of a central corneal staining score (CCSS) and a total corneal staining score (TCSS), which is clinically important. Further, such improvement of a central corneal staining score (CCSS) and a total corneal staining score (TCSS) was more significantly demonstrated in the patients with moderate-to-severe severity of dry eye. In addition, the patients with higher ocular discomfort score or higher eye dryness score, which are subjective symptoms, also showed greater improvement. Even though the same dose of tanfanercept was used, the tanfanercept-containing ophthalmic composition showed superior efficacy in the patient having more serious or severe baseline sign or symptom scores.

Abstract: Provided herein are compounds that promote targeted degradation of IKZF2, a protein whose activity is implicated in the pathology of certain cancers (e.g., acute myeloid leukemia). Also provided are pharmaceutical compositions comprising the compounds. Also provided are methods of treating cancer, and methods of promoting the degradation of IKZF2 in a subject or biological sample by administering a compound or composition described herein.

Abstract: There are provided a semiconductor device and a manufacturing method of a semiconductor device. The semiconductor device includes: a gate structure including conductive layers and insulating layers, which are alternately stacked; channel structures penetrating the gate structure, the channel structures being arranged in a first direction; and a cutting structure extending in the first direction, the cutting structure consecutively penetrating the channel structures. Each of the channel structures includes a first channel structure and a second channel structure, which are isolated from each other by the cutting structure.

Abstract: The present invention is directed to a method for producing induced electricity which prevents a collision by guiding induced electromagnetic force generated from a power generation coil as electricity is produced in the power generation coil to a predetermined location deviating from the path of power generation magnetic force which proceeds to be interlinked with the power generation coil to thus prevent power generation resistance from occurring and also produces electricity by interlinking the induced electromagnetic force with the power generation coil. The present invention is also directed to a “method for producing electricity using the induced electromagnetic force of a power generation coil” which uses an energy source for the production of electricity without conversion, so that there are no loss of energy during an energy conversion process and maintenance and management are easy, thereby reducing costs.

Abstract: A semiconductor memory device, and a method of manufacturing the same, includes a lower stack in which a plurality of first interlayer insulating layers and first conductive layers are alternately stacked, a plurality of cell plugs passing through the lower stack in a vertical direction, an upper stack in which a plurality of second interlayer insulating layers and at least one second conductive layer are alternately stacked on the lower stack, a plurality of drain select plugs passing through the upper stack and being in contact with an upper portion of the plurality of cell plugs, and a separation pattern separating adjacent drain select plugs among the plurality of drain select plugs, wherein the separation pattern is in contact with a sidewall of each of the adjacent drain select plugs.

Abstract: An electronic device and a method of measuring an amount of user physical activity by an electronic device are provided. The method includes establishing short range communication among a plurality of electronic devices, determining one of the plurality of electronic devices as a primary device, communicating state information of remaining electronic devices to the primary device, activating a sensor on a device having a highest priority among the plurality of electronic devices according to the state information, recording physical activity information according to physical activity sensed by the sensor, communicating the physical activity information to the primary device, calculating an amount of physical activity according to the communicated physical activity information, and synchronizing the amount of physical activity among the plurality of electronic devices.

Abstract: An electronic device and a method of measuring an amount of user physical activity by an electronic device are provided. The method includes establishing short range communication among a plurality of electronic devices, determining one of the plurality of electronic devices as a primary device, communicating state information of remaining electronic devices to the primary device, activating a sensor on a device having a highest priority among the plurality of electronic devices according to the state information, recording physical activity information according to physical activity sensed by the sensor, communicating the physical activity information to the primary device, calculating an amount of physical activity according to the communicated physical activity information, and synchronizing the amount of physical activity among the plurality of electronic devices.

Abstract: The present invention relates to an L-lysine-producing microorganism of the genus Corynebacterium and a method for producing L-lysine using the same.

Abstract: The present invention is directed to a method for producing induced electricity which prevents a collision by guiding induced electromagnetic force generated from a power generation coil as electricity is produced in the power generation coil to a predetermined location deviating from the path of power generation magnetic force which proceeds to be interlinked with the power generation coil to thus prevent power generation resistance from occurring and also produces electricity by interlinking the induced electromagnetic force with the power generation coil. The present invention is also directed to a “method for producing electricity using the induced electromagnetic force of a power generation coil” which uses an energy source for the production of electricity without conversion, so that there are no loss of energy during an energy conversion process and maintenance and management are easy, thereby reducing costs.

Abstract: The present invention relates to an L-lysine-producing microorganism of the genus Corynebacterium and a method for producing L-lysine using the same.