Patents by Inventor Suo W. Liu

Suo W. Liu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for preparing dideoxyinosine using adenosine deaminase enzyme
    Publication number: 20040175804
    Abstract: A method of making didanosine (ddI) including the steps of: (a) obtaining an enzyme expressing ddA deaminase activity; (b) immobilizing the enzyme onto an insoluble support; (c) contacting the enzyme with a dideoxyadenosine (ddA) solution of at least about 4% weight volume ddA in water for a time and under conditions to produce a ddI solution; and (d) isolating the ddI from the ddI solution. Optionally, the ddI mother liquor is reused in subsequent runs to improve yield.
    Type: Application
    Filed: February 26, 2004
    Publication date: September 9, 2004
    Inventors: Paul M. Skonezny, Michael Politino, Suo W. Liu, Alfred W. Boyle, Jason G. Chen, Gregory L. Stein, Thomas Franceschini, Wendy L. Anderson
  • High expression Escherichia coli expression vector
    Patent number: 6068991
    Abstract: High expression vectors for expression of heterologous genes in Escherichia coli. The expression vectors contain, the tac promoter, an intergenic region, a restriction site, and, optionally, groES DNA.
    Type: Grant
    Filed: December 4, 1998
    Date of Patent: May 30, 2000
    Assignee: Bristol-Myers Squibb Company
    Inventors: Suo W. Liu, Thomas J. Franceschini
  • D-amino acid oxidase promoter from T. variabilis
    Patent number: 6025159
    Abstract: A D-amino acid oxidase promoter isolated from T. variabilis has been incorporated into S. cerevisiae expression vectors to increase the expression of heterologous genes. The heterologous promoter has been placed upstream of selective markers, auxotrophic nutritional and/or dominant selectable markers. Because the promoter is from another yeast specie, it is weakly recognized by and S. cerevisiae. To compensate for the weak transcripts of selectable marker genes transcribed from the weak heterologous promoter, the plasmid containing the gene of the interest is amplified leading to a higher expression of protein of interest.
    Type: Grant
    Filed: June 18, 1998
    Date of Patent: February 15, 2000
    Assignee: Bristol-Myers Squibb Company
    Inventors: Suo W. Liu, Thomas Franceschini