Patents by Inventor Suo-Win Liu

Suo-Win Liu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Genetically stable plasmid expressing PDH and FDH enzymes
    Patent number: 8158394
    Abstract: Bi-cistronic plasmids used for the expression of formate dehydrogenase (FDH) and modified phenylalanine dehydrogenase (PDHmod) are provided.
    Type: Grant
    Filed: April 8, 2010
    Date of Patent: April 17, 2012
    Assignee: Bristol-Myers Squibb Company
    Inventors: Jonathan Basch, Thomas Franceschini, Suo Win Liu, Shu-Jen Chiang
  • Genetically Stable Plasmid Expressing PDH and FDH Enzymes
    Publication number: 20100261236
    Abstract: Bi-cistronic plasmids used for the expression of formate dehydrogenase (FDH) and modified phenylalanine dehydrogenase (PDHmod) are provided.
    Type: Application
    Filed: April 8, 2010
    Publication date: October 14, 2010
    Applicant: BRISTOL-MYERS SQUIBB CO.
    Inventors: Jonathan Basch, Thomas Franceschini, Suo Win Liu, Shu-Jen Chiang
  • Compositions and methods for hydroxylating epothilones
    Patent number: 7214527
    Abstract: Isolated nucleic acid sequences and polypeptides encoded thereby for epothilone B hydroxylase and mutants and variants thereof and a ferredoxin located downstream from the epothilone B hydroxylase gene are provided. Also provided are vectors and cells containing these vectors. In addition, methods for producing recombinant microorganisms, methods for using these recombinant microorganism to produce hydroxyalkyl-bearing epothilones and an epothilone analog produced by a mutant of epothilone B hydroxylase are provided.
    Type: Grant
    Filed: August 9, 2004
    Date of Patent: May 8, 2007
    Assignee: Bristol-Myers Squibb Company
    Inventors: Jonathan David Basch, Shu-Jen David Chiang, Suo-Win Liu, Akbar Nayeem, Yuhua Sun, Li You
  • Compositions and methods for hydroxylating epothilones
    Publication number: 20050208620
    Abstract: Isolated nucleic acid sequences and polypeptides encoded thereby for epothilone B hydroxylase and mutants and variants thereof and a ferredoxin located downstream from the epothilone B hydroxylase gene are provided. Also provided are vectors and cells containing these vectors. In addition, methods for producing recombinant microorganisms, methods for using these recombinant microorganism to produce hydroxyalkyl-bearing epothilones and an epothilone analog produced by a mutant of epothilone B hydroxylase are provided.
    Type: Application
    Filed: August 9, 2004
    Publication date: September 22, 2005
    Inventors: Jonathan Basch, Shu-Jen Chiang, Suo-Win Liu, Akbar Nayeem, Yuhua Sun, Li You
  • Glutaryl cephalosporin amidase from Pseudomonas diminuta BS-203
    Patent number: 6942990
    Abstract: The invention provides a glutaryl 7-ACA amidase from Pseudomonas diminuta strain BS-203, which catalyzes the hydrolysis of 7-?-(4-carboxybutanamido)-cephalosporanic acid to 7-aminocephalosporanic acid and glutaric acid. The invention also provides nucleic acid sequences, vectors, and host cells useful in the production of this amidase. The glutaryl 7-ACA amidase can be used for the preparation of 7-aminocephalosporanic acid.
    Type: Grant
    Filed: January 17, 2003
    Date of Patent: September 13, 2005
    Assignee: Bristol Myers Squibb Company
    Inventors: Ross Binder, Joanne L. Brown, Thomas J. Franceschini, William V. Burnett, Michael Politino, Suo Win Liu, Sean M. Tonzi
  • Compositions and methods for hydroxylating epothilones
    Patent number: 6884608
    Abstract: Isolated nucleic acid sequences and polypeptides encoded thereby for epothilone B hydroxylase and mutants and variants thereof and a ferredoxin located downstream from the epothilone B hydroxylase gene are provided. Also provided are vectors and cells containing these vectors. In addition, methods for producing recombinant microorganisms, methods for using these recombinant microorganism to produce hydroxyalkyl-bearing epothilones and an epothilone analog produced by a mutant of epothilone B hydroxylase are provided.
    Type: Grant
    Filed: December 17, 2002
    Date of Patent: April 26, 2005
    Assignee: Bristol-Myers Squibb Company
    Inventors: Jonathan David Basch, Shu-Jen David Chiang, Suo-Win Liu, Akbar Nayeem, Yuhua Sun, Li You
  • Compositions and methods for hydroxylating epothilones
    Publication number: 20030180760
    Abstract: Isolated nucleic acid sequences and polypeptides encoded thereby for epothilone B hydroxylase and mutants and variants thereof and a ferredoxin located downstream from the epothilone B hydroxylase gene are provided. Also provided are vectors and cells containing these vectors. In addition, methods for producing recombinant microorganisms, methods for using these recombinant microorganism to produce hydroxyalkyl-bearing epothilones and an epothilone analog produced by a mutant of epothilone B hydroxylase are provided.
    Type: Application
    Filed: December 17, 2002
    Publication date: September 25, 2003
    Inventors: Jonathan David Basch, Shu-Jen David Chiang, Suo-Win Liu, Akbar Nayeem, Yuhua Sun, Li You
  • Glutaryl cephalosporin amidase from pseudomonas diminuta BS-203
    Publication number: 20030143715
    Abstract: The invention provides a glutaryl 7-ACA amidase from Pseudomonas diminuta strain BS-203, which catalyzes the hydrolysis of 7-&bgr;-(4-carboxybutanamido)-cephalosporanic acid to 7-aminocephalosporanic acid and glutaric acid. The invention also provides nucleic acid sequences, vectors, and host cells useful in the production of this amidase. The glutaryl 7-ACA amidase can be used for the preparation of 7-aminocephalosporanic acid.
    Type: Application
    Filed: January 17, 2003
    Publication date: July 31, 2003
    Inventors: Ross Binder, Joanne L. Brown, Thomas J. Franceschini, William V. Burnett, Michael Politino, Suo Win Liu, Sean M. Tonzi
  • Glutaryl cephalosporin amidase from Pseudomonas diminuta BS-203
    Patent number: 6528300
    Abstract: The invention provides a glutaryl 7-ACA amidase from Pseudomonas diminuta strain BS-203, which catalyzes the hydrolysis of 7-&bgr;-(4-carboxybutanamido)-cephalosporanic acid to 7-aminocephalosporanic acid and glutaric acid. The invention also provides nucleic acid sequences, vectors, and host cells useful in the production of this amidase. The glutaryl 7-ACA amidase can be used for the preparation of 7-aminocephalosporanic acid.
    Type: Grant
    Filed: September 21, 2001
    Date of Patent: March 4, 2003
    Assignee: Bristol-Myers Squibb Co.
    Inventors: Ross Binder, Joanne L. Brown, Thomas J. Franceschini, William V. Burnett, Michael Politino, Suo Win Liu, Sean M. Tonzi
  • Glutaryl cephalosporin amidase from pseudomonas diminuta BS-203
    Publication number: 20020160500
    Abstract: The invention provides a glutaryl 7-ACA amidase from Pseudomonas diminuta strain BS-203, which catalyzes the hydrolysis of 7-&bgr;-(4-carboxybutanamido)-cephalosporanic acid to 7-aminocephalosporanic acid and glutaric acid. The invention also provides nucleic acid sequences, vectors, and host cells useful in the production of this amidase. The glutaryl 7-ACA amidase can be used for the preparation of 7-aminocephalosporanic acid.
    Type: Application
    Filed: September 21, 2001
    Publication date: October 31, 2002
    Inventors: Ross Binder, Joanne L. Brown, Thomas J. Franceschini, William V. Burnett, Michael Politino, Suo Win Liu, Sean M. Tonzi