Abstract: A method for preparing a novel crystal form F of trelagliptin includes: adding a mediating protein into the trelagliptin to obtain a mixture, and introducing a mechanochemical action on the mixture for transformation of a crystal form of the trelagliptin to obtain the novel crystal form F of trelagliptin. The preparation method does not require any organic solvent and thus will not lead to an organic solvent residue to affect the safety of medication. In addition, the preparation method is less time-consuming than a solvent crystallization method, is easy to allow green industrial production, and has characteristics such as simplicity, high efficiency, safety, and environmental friendliness.

Abstract: A method for preparing a novel crystal form F of trelagliptin includes: adding a mediating protein into the trelagliptin to obtain a mixture, and introducing a mechanochemical action on the mixture for transformation of a crystal form of the trelagliptin to obtain the novel crystal form F of trelagliptin. The preparation method does not require any organic solvent and thus will not lead to an organic solvent residue to affect the safety of medication. In addition, the preparation method is less time-consuming than a solvent crystallization method, is easy to allow green industrial production, and has characteristics such as simplicity, high efficiency, safety, and environmental friendliness.