Patents by Inventor Surendra Gokhale

Surendra Gokhale has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for producing 2-isoquinoline compounds
    Patent number: 5256783
    Abstract: 1,2,3,4-Tetrahydro-2-isoquinoline-derivatives of the formula ##STR1## wherein R signifies hydroxy, lower alkylamino, lower alkoxy or phenyl-C.sub.2-6 -alkoxy which can carry one or more lower alkyl or lower alkoxy substituents on the phenyl ring,can be manufactured by cyclizing a phenethylamine derivative of the formula ##STR2## wherein Z signifies benzyloxycarbonyl and R" signifies hydroxy, lower alkylamino, lower alkoxy or phenyl-lower-alkoxy which can carry one or more lower alkyl or lower alkoxy substituents on the phenyl ring,with formaldehyde in the presence of sulphuric acid in acetic acid to a corresponding tetrahydroisoquinoline derivative of the formula ##STR3## and cleaving off the group Z in the compound obtained.
    Type: Grant
    Filed: September 2, 1992
    Date of Patent: October 26, 1993
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Surendra Gokhale, Markus Schlageter