Patents by Inventor Surendra N. Sehgal

Surendra N. Sehgal has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20040097538
    Abstract: This invention provides a method of treating or inhibiting cardiovascular, cerebral vascular, or peripheral vascular disease in a mammal in need thereof, which comprises providing said mammal with an effective amount of a rapamycin.
    Type: Application
    Filed: October 29, 2003
    Publication date: May 20, 2004
    Applicant: Wyeth
    Inventors: Neal I. Azrolan, Surendra N. Sehgal, Uma Sehgal, Steven J. Adelman
  • Patent number: 6670355
    Abstract: This invention provides a method of treating or inhibiting cardiovascular, cerebral vascular, or peripheral vascular disease in a mammal in need thereof, which comprises providing said mammal with an effective amount of a rapamycin.
    Type: Grant
    Filed: December 6, 2002
    Date of Patent: December 30, 2003
    Assignee: Wyeth
    Inventors: Neal I. Azrolan, Steven J. Adelman, Surendra N. Sehgal
  • Publication number: 20030149070
    Abstract: This invention provides a method of treating or inhibiting cardiovascular, cerebral vascular, or peripheral vascular disease in a mammal in need thereof, which comprises providing said mammal with an effective amount of a rapamycin.
    Type: Application
    Filed: December 6, 2002
    Publication date: August 7, 2003
    Applicant: Wyeth
    Inventors: Neal I. Azrolan, Surendra N. Sehgal, Steven J. Adelman
  • Publication number: 20020013335
    Abstract: This invention provides a method of treating or inhibiting cardiovascular, cerebral vascular, or peripheral vascular disease in a mammal in need thereof, which comprises providing said mammal with an effective amount of a rapamycin.
    Type: Application
    Filed: June 13, 2001
    Publication date: January 31, 2002
    Applicant: American Home Products Corporation
    Inventors: Neal I. Azrolan, Surendra N. Sehgal, Steven J. Adelman
  • Patent number: 5622963
    Abstract: This invention relates to a technique for treating a mammal with rapamycin which comprises removal of blood from the patient, treatment of the formed blood elements with rapamycin which binds rapidly and reversibly with erythrocytes, and returning the treated blood cells to the circulatory system of the patient for the treatment of any of the diseases, syndromes, conditions, or immune responses which respond to treatment with rapamycin. Alternatively, blood to be treated with rapamycin can be obtained from a hematologically compatible donor mammal.
    Type: Grant
    Filed: April 18, 1995
    Date of Patent: April 22, 1997
    Assignee: American Home Products Corporation
    Inventors: Jay J. Armstrong, Surendra N. Sehgal
  • Patent number: 5547959
    Abstract: This invention relates to a technique for treating a mammal with rapamycin which comprises removal of blood from the patient, treatment of the formed blood elements with rapamycin which binds rapidly and reversibly with erythrocytes, and returning the treated blood cells to the circulatory system of the patient for the treatment of any of the diseases, syndromes, conditions, or immune responses which respond to treatment with rapamycin. Alternatively, blood to be treated with rapamycin can be obtained from a hematologically compatible donor mammal.
    Type: Grant
    Filed: April 18, 1995
    Date of Patent: August 20, 1996
    Assignee: American Home Products Corporation
    Inventors: Jay J. Armstrong, Surendra N. Sehgal
  • Patent number: 5543418
    Abstract: This invention relates to a technique for treating a mammal with rapamycin which comprises removal of blood from the patient, treatment of the formed blood elements with rapamycin which binds rapidly and reversibly with erythrocytes, and returning the treated blood cells to the circulatory system of the patient for the treatment of any of the diseases, syndromes, conditions, or immune responses which respond to treatment with rapamycin. Alternatively, blood to be treated with rapamycin can be obtained from a hematologically compatible donor mammal.
    Type: Grant
    Filed: April 18, 1995
    Date of Patent: August 6, 1996
    Assignee: American Home Products Corporation
    Inventors: Jay J. Armstrong, Surendra N. Sehgal
  • Patent number: 5482945
    Abstract: This invention relates to a technique for treating a mammal with rapamycin which comprises removal of blood from the patient, treatment of the formed blood elements with rapamycin which binds rapidly and reversibly with erythrocytes, and returning the treated blood cells to the circulatory system of the patient for the treatment of any of the diseases, syndromes, conditions, or immune responses which respond to treatment with rapamycin. Alternatively, blood to be treated with rapamycin can be obtained from a hematologically compatible donor mammal.
    Type: Grant
    Filed: December 22, 1992
    Date of Patent: January 9, 1996
    Assignee: American Home Products Corporation
    Inventors: Jay J. Armstrong, Surendra N. Sehgal
  • Patent number: 5441977
    Abstract: A compound which is 21-norrapamycin or a pharmaceutically acceptable salt thereof, which is useful as an immunosuppressive, anti-inflammatory, antifungal, antitumor, and antiproliferative agent. 21-Norrapamycin has the following structure.
    Type: Grant
    Filed: March 1, 1994
    Date of Patent: August 15, 1995
    Assignee: American Home Products Corporation
    Inventors: Ralph J. Russo, Stanley R. Howell, Surendra N. Sehgal
  • Patent number: 5321009
    Abstract: This invention provides a method of prophylactically preventing the onset, preventing the development, and arresting the progression of insulin dependent diabetes mellitus in a mammal by administering an effective amount of rapamycin either alone or in combination with insulin.
    Type: Grant
    Filed: November 14, 1991
    Date of Patent: June 14, 1994
    Assignee: American Home Products Corporation
    Inventors: William L. Baeder, Surendra N. Sehgal, Laurel M. Adams, Thomas J. Caggiano
  • Patent number: 5286730
    Abstract: This invention provides a method of treating immunionflammatory skin disease in a mammal in need thereof which comprises administering an antiimmunoinflammatory amount of rapamycin, alone or in combination with cyclosporin A, orally, parenterally, intranasally, intrabronchially, topically, transdermally, or rectally. As such, rapamycin, alone or in combination with cyclosporin A, is useful in treating skin diseases such as psoriasis, atopic dermatitis, contact dermatitis, eczematous dermatitis, seborrheic dermatitis, Lichen planus, Pemphigus, bulus pemphigoid, Epidermolysis bullosa, urticaria, angioedemas, vasculitides, erythemas, cutaneous eosinphilias, and the like.
    Type: Grant
    Filed: August 17, 1992
    Date of Patent: February 15, 1994
    Assignee: American Home Products Corporation
    Inventors: Craig E. Caufield, John H. Musser, Surendra N. Sehgal
  • Patent number: 5286731
    Abstract: This invention provides a method of treating immunoinflammatory bowel disease in a mammal in need thereof which comprises administering an antiimmunoinflammatory amount of rapamycin, alone or in combination with cyclosporin A. As such, rapamycin, alone or in combination with cyclosporin A, is useful in treating bowel diseases such as ulcerative colitis, Crohn's disease, ulcerative proctitis, and the like.
    Type: Grant
    Filed: August 17, 1992
    Date of Patent: February 15, 1994
    Assignee: American Home Products Corporation
    Inventors: Craig E. Caufield, John H. Musser, Surendra N. Sehgal
  • Patent number: 5206018
    Abstract: This invention provides a method of treating, inhibiting the proliferation of, reducing the size of, or eradicating malignant neoplasms in a mammal in need thereof which comprises administering an antineoplastic amount of rapamycin to said mammal. In particular, rapamycin is useful in treating, inhibiting the proliferation of, reducing the size of, or eradicating malignant mammary and skin carcinomas, and central nervous system neoplasms.
    Type: Grant
    Filed: October 29, 1991
    Date of Patent: April 27, 1993
    Assignee: Ayerst, McKenna & Harrison, Inc.
    Inventors: Surendra N. Sehgal, Claude Vezina
  • Patent number: 5066493
    Abstract: Methods of using rapamycin in the treatment of cancers or tumors are disclosed.
    Type: Grant
    Filed: April 9, 1991
    Date of Patent: November 19, 1991
    Assignee: American Home Products Corporation
    Inventors: Surendra N. Sehgal, Claude Vezina
  • Patent number: 4994381
    Abstract: Disclosed herein are N-[[6-methoxy-5-(trifluoromethyl)-1-naphthalenyl]-thioxmethyl]-N-methylgly cine S-oxide (tolrestat S-oxide) and the amine thereof and methods of their preparation. The S-oxides are new aldose reductase inhibitors useful for the treatment or prevention of diabetic complications.
    Type: Grant
    Filed: March 20, 1989
    Date of Patent: February 19, 1991
    Assignee: American Home Products Corporation
    Inventors: Eckhardt S. Ferdinandi, Michael S. Malamas, Kazimir Sestanj, Surendra N. Sehgal
  • Patent number: 4853484
    Abstract: Disclosed herein are N-[[6-methoxy-5-(trifluoromethyl)-1-naphthalenyl]thioxomethyl]-N-methylgly cine S-oxide (tolrestat S-oxide) and the amide thereof and methods of their preparation. The S-oxides are new aldose reductase inhibitors useful for the treatment or prevention of diabetic complications.
    Type: Grant
    Filed: October 28, 1987
    Date of Patent: August 1, 1989
    Assignee: American Home Products Corporation
    Inventors: Eckhardt S. Ferdinandi, Michael S. Malamas, Kazimir Sestanj, Surendra N. Sehgal
  • Patent number: 4734435
    Abstract: Disclosed herein are N-[[6-methoxy-5-(trifluoromethyl)-1-naphthalenyl]-thioxomethyl]-N-methylgl ycine S-oxide (tolrestat S-oxide) and the amide thereof and methods of their preparation. The S-oxides are new aldose reductase inhibitors useful for the treatment of prevention of diabetic complications.
    Type: Grant
    Filed: November 25, 1986
    Date of Patent: March 29, 1988
    Assignee: American Home Products Corp.
    Inventors: Eckhardt S. Ferdinandi, Michael S. Malamas, Kazimir Sestanj, Surendra N. Sehgal
  • Patent number: 4375463
    Abstract: Ravidomycin is produced by culturing Streptomyces ravidus NRRL 11,300 in an aqueous nutrient medium. Ravidomycin is useful as an antibacterial and antitumor agent. Methods for its preparation and use are disclosed.
    Type: Grant
    Filed: March 13, 1981
    Date of Patent: March 1, 1983
    Assignee: Ayerst, McKenna & Harrison, Inc.
    Inventors: Surendra N. Sehgal, Claude Vezina
  • Patent number: 4375464
    Abstract: Antibiotic AY24,668 is producible by culturing Streptomyces hygroscopicus NRRL 5491 in an aqueous nutrient medium. AY24,668 has antifungal properties. Methods for its preparation and use are disclosed.
    Type: Grant
    Filed: November 19, 1981
    Date of Patent: March 1, 1983
    Assignee: Ayerst, McKenna & Harrison Inc.
    Inventors: Surendra N. Sehgal, Claude Vezina
  • Patent number: 4230692
    Abstract: Ravidomycin is produced by culturing Streptomyces ravidus NRRL 11,300 in an aqueous nutrient medium. Ravidomycin is useful as an antibacterial agent. Methods for its preparation and use are disclosed.
    Type: Grant
    Filed: November 3, 1978
    Date of Patent: October 28, 1980
    Assignee: Ayerst McKenna & Harrison, Inc.
    Inventors: Surendra N. Sehgal, Claude Vezina