Publication number: 20210171538
Abstract: The present invention relates to nimbolide analogs useful as anti-cancer agents and preparation thereof. Particularly the present invention relates to nimbolide analogs of general formula I. wherein, ring M is any ring selected from the group consisting of substituted or unsubstituted aryl, heteroaryl, cycloalkyl and heterocyclic; A and B are selected from the group consisting of C, O, N, S and H; R1, R2, R3, R4, R5 and R6 are selected from the group consisting of C1-C6 alkyl, aryl, heteroaryl, C1-C7 cycloalkyl, heteroalkyl, hydrogen, hydroxy, alkoxy, nitro, halogen, amino, alkylamino, aryl amino and cyano; wherein each of these groups may be further substituted with one or more substituents selected from the group consisting of hydrogen, hydroxy, halogen, cyano, alkyl amino, aryl amino, alkoxy, amino, nitro, aldehyde, carboxylic acid and ester.
Type:
Application
Filed:
February 9, 2021
Publication date:
June 10, 2021
Applicant:
Council of Scientific & Industrial Research
Inventors:
Srivari Chandrasekhar, Prathama Satyendra Mainkar, Karre Nagaraju, Togapur Pavan Kumar, Ummanni Ramesh, Kanchanapally Tejaswini, Jerald Mahesh Kumar, Katragadda Suresh Babu, Boggavarapu Subrahmanya Sastry, Debabrata Mukhopadhyay