Patents by Inventor Suresh Gadde

Suresh Gadde has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Nanoparticles for targeted delivery of multiple therapeutic agents and methods of use
    Patent number: 9931410
    Abstract: Provided herein are compositions that contain a nanoparticle containing a plurality of polymers, wherein at least a fraction of the polymers comprise a hydrophobic polymer, a topoisomerase inhibitor, and a Pt-containing chemotherapeutic agent, where the polymers self-assemble in an aqueous liquid to form the nanoparticle, and where the Pt-containing chemotherapeutic agent and the topoisomerase inhibitor are present within the hydrophobic core of the nanoparticle in a ratio of between about 24:1 to about 1:24. Also provided are methods of reducing the proliferation of a cancer cell and methods of treating cancer in a subject that include the use of these compositions. Also provided are methods of making these nanoparticles.
    Type: Grant
    Filed: October 9, 2013
    Date of Patent: April 3, 2018
    Assignees: The Brigham and Women's Hospital, Inc., Massachusetts Institute of Technology
    Inventors: Pedro M. Valencia, Eric M. Pridgen, Suresh Gadde, Rohit Karnik, Robert S. Langer, Stephen J. Lippard, Omid C. Farokhzad
  • Nanoparticles For Targeted Delivery of Multiple Therapeutic Agents and Methods of Use
    Publication number: 20150265716
    Abstract: Provided herein are compositions that contain a nanoparticle containing a plurality of polymers, wherein at least a fraction of the polymers comprise a hydrophobic polymer, a topoisomerase inhibitor, and a Pt-containing chemotherapeutic agent, where the polymers self-assemble in an aqueous liquid to form the nanoparticle, and where the Pt-containing chemotherapeutic agent and the topoisomerase inhibitor are present within the hydrophobic core of the nanoparticle in a ratio of between about 24:1 to about 1:24. Also provided are methods of reducing the proliferation of a cancer cell and methods of treating cancer in a subject that include the use of these compositions. Also provided are methods of making these nanoparticles.
    Type: Application
    Filed: October 9, 2013
    Publication date: September 24, 2015
    Inventors: Pedro M. Valencia, Eric M. Pridgen, Suresh Gadde, Rohit Karnik, Robert S. Langer, Stephen J. Lippard, Omid C. Farokhzad