Patents by Inventor Suresh Gangadevi

Suresh Gangadevi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20210388455
    Abstract: The present disclosure relates to an in-silico analysis for inhibitors of Severe Acute Respiratory Syndrome Corona Virus 2 (SARS-CoV-2). The in-silico screening of Kobophenol A confirmed the effective binding at two positions, firstly at ACE2/Spike interface and secondly at the hydrophobic pocket by destabilizing the complex formation. Kobophenol A inhibited the cell death caused by viral infection without inducing cell toxicity in the absence of viral infection. The molecular dynamics of Kobophenol A indicated the stability of binding of Kobophenol A through hydrogen bond and stabilized at Y495 and K353 with an average distance of 2.95 ?. The binding affinity of Kobophenol A to the ACE2/Spike interface region and the ACE2 hydrophobic pocket is computed to be ?19.0±4.3 and ?24.9±6.9 kcal/mol respectively. Kobophenol A is useful as a potential drug for treatment of COVID-19.
    Type: Application
    Filed: June 14, 2021
    Publication date: December 16, 2021
    Inventors: Suresh Gangadevi, Yin Na, Wang Ke, Vishnu Nayak Badavath