Patents by Inventor Suresh K. Manthati

Suresh K. Manthati has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • TREATMENT OF MULTIPLE SCLEROSIS AND PSORIASIS USING PRODRUGS OF METHYL HYDROGEN FUMARATE
    Publication number: 20200087272
    Abstract: Improved methods of treating multiple sclerosis and/or psoriasis using prodrugs of methyl hydrogen fumarate are disclosed. The methods comprise administering certain prodrugs of methyl hydrogen fumarate. The methods are able to achieve high blood plasma concentrations of the active metabolite, methyl hydrogen fumarate, without causing significant gastrointestinal irritation. New prodrugs of methyl hydrogen fumarate are also disclosed.
    Type: Application
    Filed: April 29, 2019
    Publication date: March 19, 2020
    Applicant: Arbor Pharmaceuticals, LLC
    Inventors: Peter A. Virsik, David J. Wustrow, Thamil Annamalai, Suresh K. Manthati
  • Treatment of Multiple Sclerosis and Psoriasis Using Prodrugs of Methyl Hydrogen Fumarate
    Publication number: 20190256481
    Abstract: Improved methods of treating multiple sclerosis and/or psoriasis using prodrugs of methyl hydrogen fumarate are disclosed. The methods comprise administering certain prodrugs of methyl hydrogen fumarate. The methods are able to achieve high blood plasma concentrations of the active metabolite, methyl hydrogen fumarate, without causing significant gastrointestinal irritation. New prodrugs of methyl hydrogen fumarate are also disclosed.
    Type: Application
    Filed: May 3, 2019
    Publication date: August 22, 2019
    Inventors: Peter A. Virsik, David J. Wustrow, Thamil Annamalai, Suresh K. Manthati
  • Treatment of Multiple Sclerosis and Psoriasis Using Prodrugs of Methyl Hydrogen Fumarate
    Publication number: 20190256480
    Abstract: Improved methods of treating multiple sclerosis and/or psoriasis using prodrugs of methyl hydrogen fumarate are disclosed. The methods comprise administering certain prodrugs of methyl hydrogen fumarate. The methods are able to achieve high blood plasma concentrations of the active metabolite, methyl hydrogen fumarate, without causing significant gastrointestinal irritation. New prodrugs of methyl hydrogen fumarate are also disclosed.
    Type: Application
    Filed: May 3, 2019
    Publication date: August 22, 2019
    Inventors: Peter A. Virsik, David J. Wustrow, Thamil Annamalai, Suresh K. Manthati
  • TREATMENT OF MULTIPLE SCLEROSIS AND PSORIASIS USING PRODRUGS OF METHYL HYDROGEN FUMARATE
    Publication number: 20180273500
    Abstract: Improved methods of treating multiple sclerosis and/or psoriasis using prodrugs of methyl hydrogen fumarate are disclosed. The methods comprise administering certain prodrugs of methyl hydrogen fumarate. The methods are able to achieve high blood plasma concentrations of the active metabolite, methyl hydrogen fumarate, without causing significant gastrointestinal irritation. New prodrugs of methyl hydrogen fumarate are also disclosed.
    Type: Application
    Filed: May 31, 2018
    Publication date: September 27, 2018
    Applicant: XenoPort, Inc.
    Inventors: Peter A. Virsik, David J. Wustrow, Thamil Annamalai, Suresh K. Manthati
  • TREATMENT OF MULTIPLE SCLEROSIS AND PSORIASIS USING PRODRUGS OF METHYL HYDROGEN FUMARATE
    Publication number: 20180237405
    Abstract: Improved methods of treating multiple sclerosis and/or psoriasis using prodrugs of methyl hydrogen fumarate are disclosed. The methods comprise administering certain prodrugs of methyl hydrogen fumarate. The methods are able to achieve high blood plasma concentrations of the active metabolite, methyl hydrogen fumarate, without causing significant gastrointestinal irritation. New prodrugs of methyl hydrogen fumarate are also disclosed.
    Type: Application
    Filed: April 19, 2018
    Publication date: August 23, 2018
    Applicant: XenoPort, Inc.
    Inventors: Peter A. Virsik, David J. Wustrow, Thamil Annamalai, Suresh K. Manthati
  • Methods of synthesizing a levodopa ester prodrug
    Patent number: 9533941
    Abstract: Methods of synthesizing a levodopa ester prodrug, salts thereof, and synthetic intermediates thereof are disclosed.
    Type: Grant
    Filed: February 12, 2016
    Date of Patent: January 3, 2017
    Assignee: XENOPORT, INC.
    Inventors: Stephen P. Raillard, Adam Mann, Suresh K. Manthati, Randall A. Scheuerman, Tono Estrada, Mark Q. Nguyen, Cindy X. Zhou
  • METHODS OF SYNTHESIZING A LEVODOPA ESTER PRODRUG
    Publication number: 20160176804
    Abstract: Methods of synthesizing a levodopa ester prodrug, salts thereof, and synthetic intermediates thereof are disclosed.
    Type: Application
    Filed: February 12, 2016
    Publication date: June 23, 2016
    Inventors: STEPHEN P. RAILLARD, ADAM MANN, SURESH K. MANTHATI, RANDALL A. SCHEUERMAN, TONO ESTRADA, MARK Q. NGUYEN, CINDY X. ZHOU
  • Synthesis of acyloxyalkyl carbamate prodrugs and intermediates thereof
    Patent number: 9353057
    Abstract: Methods for synthesis of 1-(acyloxy)-alkyl carbamates, particularly, the synthesis of 1-(acyloxy)-alkyl carbamate prodrugs of primary or secondary amine-containing drugs are described. Also described are methods for synthesis of 1-(acyloxy)-alkyl N-hydroxysuccinimidyl carbonates which are useful intermediates in the synthesis of 1-(acyloxy)-alkyl carbamates are also described.
    Type: Grant
    Filed: January 15, 2013
    Date of Patent: May 31, 2016
    Assignee: XenoPort, Inc.
    Inventors: Mark A. Gallop, Xuedong Dai, Randall A. Scheuerman, Stephen P. Raillard, Suresh K. Manthati, Fenmei Yao, Thu Phan, Maria Ludwikow, Ge Peng, Seema Bhat
  • Method of making monomethyl fumarate
    Patent number: 9302977
    Abstract: Methods of making monomethyl fumarate, which can then also be used in methods of making prodrugs of monomethyl fumarate, are disclosed. Monomethyl fumarate and prodrugs of monomethyl fumarate are useful for treating neurodegenerative, inflammatory, and autoimmune diseases including multiple sclerosis, psoriasis, irritable bowel disorder, ulcerative colitis, arthritis, chronic obstructive pulmonary disease, asthma, Parkinson's disease, Huntington's disease, and amyotrophic lateral sclerosis.
    Type: Grant
    Filed: June 6, 2014
    Date of Patent: April 5, 2016
    Assignee: XenoPort, Inc.
    Inventors: Stephen P. Raillard, Randall A. Scheuerman, Suresh K. Manthati
  • Methods of synthesizing a levodopa ester prodrug
    Patent number: 9290445
    Abstract: Methods of synthesizing a levodopa ester prodrug, salts thereof, and synthetic intermediates thereof are disclosed.
    Type: Grant
    Filed: October 19, 2009
    Date of Patent: March 22, 2016
    Assignee: XenoPort, Inc.
    Inventors: Stephen P. Raillard, Adam Mann, Suresh K. Manthati, Randall A. Scheuerman, Tono Estrada, Mark Q. Nguyen, Cindy X Zhou
  • Anhydrous and hemihydrate crystalline forms of an ()-baclofen prodrug, methods of synthesis and methods of use
    Patent number: 9265748
    Abstract: Crystalline (3R)-4-{[(1S)-2-methyl-1-(2-methylpropanoyloxyl)propoxy]carbonylamino}-3-(4-chlorophenyl)butanoic acid anhydrate and crystalline (3R)-4-{[(1S)-2-methyl-1-(2-methylpropanoyloxyl)propoxy]carbonylamino}-3-(4-chlorophenyl)butanoic acid hemihydrate, pharmaceutical compositions comprising such compounds, methods of making and methods of using the same are disclosed.
    Type: Grant
    Filed: July 14, 2015
    Date of Patent: February 23, 2016
    Assignee: XenoPort, Inc.
    Inventors: Stephen P. Raillard, Suresh K. Manthati, Sudhir Joshi
  • ANHYDROUS AND HEMIHYDRATE CRYSTALLINE FORMS OF AN (R)-BACLOFEN PRODRUG, METHODS OF SYNTHESIS AND METHODS OF USE
    Publication number: 20150313865
    Abstract: Crystalline (3R)-4-{[(1S)-2-methyl-1-(2-methylpropanoyloxyl)propoxy]carbonylamino}-3-(4-chlorophenyl)butanoic acid anhydrate and crystalline (3R)-4-{[(1S)-2-methyl-1-(2-methylpropanoyloxyl)propoxy]carbonylamino}-3-(4-chlorophenyl)butanoic acid hemihydrate, pharmaceutical compositions comprising such compounds, methods of making and methods of using the same are disclosed.
    Type: Application
    Filed: July 14, 2015
    Publication date: November 5, 2015
    Applicant: XenoPort, Inc.
    Inventors: Stephen P. Raillard, Suresh K. Manthati, Sudhir Joshi
  • Anhydrous and hemihydrate crystalline forms of an ()-baclofen prodrug, methods of synthesis and methods of use
    Patent number: 9139517
    Abstract: Crystalline (3R)-4-{[(1S)-2-methyl-1-(2-methylpropanoyloxy)propoxy]carbonylamino}-3-(4-chlorophenyl)butanoic acid anhydrate and crystalline (3R)-4-{[(1S)-2-methyl-1-(2-methylpropanoyloxy)propoxy]carbonylamino}-3-(4-chlorophenyl)butanoic acid hemihydrate, pharmaceutical compositions comprising such compounds, methods of making and methods of using the same are disclosed.
    Type: Grant
    Filed: November 11, 2013
    Date of Patent: September 22, 2015
    Assignee: XenoPort, Inc.
    Inventors: Stephen P. Raillard, Suresh K. Manthati, Sudhir Joshi
  • TREATMENT OF MULTIPLE SCLEROSIS AND PSORIASIS USING PRODRUGS OF METHYL HYDROGEN FUMARATE
    Publication number: 20150252013
    Abstract: Improved methods of treating multiple sclerosis and/or psoriasis using prodrugs of methyl hydrogen fumarate are disclosed. The methods comprise administering certain prodrugs of methyl hydrogen fumarate. The methods are able to achieve high blood plasma concentrations of the active metabolite, methyl hydrogen fumarate, without causing significant gastrointestinal irritation. New prodrugs of methyl hydrogen fumarate are also disclosed.
    Type: Application
    Filed: May 20, 2015
    Publication date: September 10, 2015
    Inventors: Peter A. Virsik, David J. Wustrow, Thamil Annamalai, Suresh K. Manthati
  • Morpholinoalkyl fumarate compounds, pharmaceutical compositions, and methods of use
    Patent number: 8952006
    Abstract: Morpholinoalkyl fumarates, pharmaceutical compositions comprising the morpholinoalkyl fumarates, and methods of using morpholinoalkyl fumarates and pharmaceutical compositions for treating neurodegenerative, inflammatory, and autoimmune disorders including multiple sclerosis, psoriasis, irritable bowel disorder, ulcerative colitis, arthritis, chronic obstructive pulmonary disease, asthma, Parkinson's disease, Huntington's disease, and amyotrophic lateral sclerosis are disclosed.
    Type: Grant
    Filed: February 7, 2013
    Date of Patent: February 10, 2015
    Assignee: XenoPort, Inc.
    Inventors: Kenneth C. Cundy, Suresh K. Manthati, David J. Wustrow
  • METHOD OF MAKING MONOMETHYL FUMARATE
    Publication number: 20140364604
    Abstract: Methods of making monomethyl fumarate, which can then also be used in methods of making prodrugs of monomethyl fumarate, are disclosed. Monomethyl fumarate and prodrugs of monomethyl fumarate are useful for treating neurodegenerative, inflammatory, and autoimmune diseases including multiple sclerosis, psoriasis, irritable bowel disorder, ulcerative colitis, arthritis, chronic obstructive pulmonary disease, asthma, Parkinson's disease, Huntington's disease, and amyotrophic lateral sclerosis.
    Type: Application
    Filed: June 6, 2014
    Publication date: December 11, 2014
    Inventors: Stephen P. Raillard, Randall A. Scheuerman, Suresh K. Manthati
  • Anhydrous and Hemihydrate Crystalline Forms of an (R)-Baclofen Prodrug, Methods of Synthesis and Methods of Use
    Publication number: 20140066501
    Abstract: Crystalline (3R)-4-{[(1S)-2-methyl-1-(2-methylpropanoyloxy)propoxy]carbonylamino}-3-(4-chlorophenyl)butanoic acid anhydrate and crystalline (3R)-4-{[(1S)-2-methyl-1-(2-methylpropanoyloxy)propoxy]carbonylamino}-3-(4-chlorophenyl)butanoic acid hemihydrate, pharmaceutical compositions comprising such compounds, methods of making and methods of using the same are disclosed.
    Type: Application
    Filed: November 11, 2013
    Publication date: March 6, 2014
    Applicant: XenoPort, Inc.
    Inventors: Stephen P. Raillard, Suresh K. Manthati, Sudhir Joshi
  • Morpholinoalkyl Fumarate Compounds, Pharmaceutical Compositions, and Methods of Use
    Publication number: 20140051705
    Abstract: Morpholinoalkyl fumarates, pharmaceutical compositions comprising the morpholinoalkyl fumarates, and methods of using morpholinoalkyl fumarates and pharmaceutical compositions for treating neurodegenerative, inflammatory, and autoimmune disorders including multiple sclerosis, psoriasis, irritable bowel disorder, ulcerative colitis, arthritis, chronic obstructive pulmonary disease, asthma, Parkinson's disease, Huntington's disease, and amyotrophic lateral sclerosis are disclosed.
    Type: Application
    Filed: August 14, 2013
    Publication date: February 20, 2014
    Applicant: XenoPort, Inc.
    Inventors: Kenneth C. Cundy, Suresh K. Manthati, David J. Wustrow
  • Anhydrous and hemihydrate crystalline forms of an ()-baclofen prodrug, methods of synthesis and methods of use
    Patent number: 8580850
    Abstract: Crystalline (3R)-4-{[(1S)-2-methyl-1-(2-methylpropanoyloxy)propoxy]carbonylamino}-3-(4-chlorophenyl)butanoic acid anhydrate and crystalline (3R)-4-{[(1S)-2-methyl-1-(2-methylpropanoyloxy)propoxy]carbonylamino}-3-(4-chlorophenyl)butanoic acid hemihydrate, pharmaceutical compositions comprising such compounds, methods of making and methods of using the same are disclosed.
    Type: Grant
    Filed: August 10, 2012
    Date of Patent: November 12, 2013
    Assignee: XenoPort, Inc.
    Inventors: Stephen P. Raillard, Suresh K. Manthati, Sudhir Joshi
  • Synthesis of acyloxyalkyl carbamate prodrugs and intermediates thereof
    Patent number: 8378137
    Abstract: Methods for synthesis of 1-(acyloxy)-alkyl carbamates, particularly, the synthesis of 1-(acyloxy)-alkyl carbamate prodrugs of primary or secondary amine-containing drugs are described. Also described are methods for synthesis of 1-(acyloxy)-alkyl N-hydroxysuccinimidyl carbonates which are useful intermediates in the synthesis of 1-(acyloxy)-alkyl carbamates are also described.
    Type: Grant
    Filed: August 11, 2011
    Date of Patent: February 19, 2013
    Assignee: XenoPort, Inc.
    Inventors: Mark A. Gallop, Xuedong Dai, Randall A. Scheuerman, Stephen P. Raillard, Suresh K. Manthati, Fenmei Yao, Thu Phan, Maria Ludwikow, Ge Peng, Seema Bhat