Patents by Inventor Suresh K. Tikoo
Suresh K. Tikoo has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20220154209Abstract: The present application provided defective bovine adenovirus (BAV) vectors that lack pV function. Cell lines and methods of preparing such vectors are provided. In addition, the invention provides methods of treating a disease or disorder with a defective BAV lacking pV function as well as vaccine comprising a defective BAV lacking pV function.Type: ApplicationFiled: August 2, 2021Publication date: May 19, 2022Inventors: Suresh K. TIKOO, Xin ZHAO
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Publication number: 20190323033Abstract: The present application provided defective bovine adenovirus (BAV) vectors that lack pV function. Cell lines and methods of preparing such vectors are provided. In addition, the invention provides methods of treating a disease or disorder with a defective BAV lacking pV function as well as vaccine comprising a defective BAV lacking pV function.Type: ApplicationFiled: June 23, 2017Publication date: October 24, 2019Inventors: Suresh K. TIKOO, Xin ZHAO
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Patent number: 7687615Abstract: The present invention provides porcine adenovirus sequence essential for encapsidation and provides adenovirus vectors comprising such sequences. The present invention provides host cells and composition comprising adenovirus vectors comprising porcine adenovirus sequence essential for encapsidation as well as methods for making and using such adenovirus vectors. The present invention discloses porcine adenovirus sequence for E1 transcriptional control and provides porcine adenovirus vectors comprising a modification(s) in the E1 transcriptional control region.Type: GrantFiled: July 18, 2003Date of Patent: March 30, 2010Assignee: University of SaskatchewanInventor: Suresh K. Tikoo
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Publication number: 20100008947Abstract: The present invention relates to the characterization of the porcine adenovirus E1 and E4 regions. The complete nucleotide sequence of the genome of porcine adenovirus type 3 (PAV-3), providing the characterization of the PAV3 E1 region, is described herein. Methods for construction of infectious PAV genomes by homologous recombination in procaryotic cells are provided. Recombinant PAV viruses are obtained by transfection of mammalian cells with recombinant PAV genomes. The PAV-3 genome can be used as a vector for the expression of heterologous nucleotide sequences, for example, for the preparation and administration of subunit vaccines to swine or other mammals.Type: ApplicationFiled: June 19, 2009Publication date: January 14, 2010Inventor: SURESH K. TIKOO
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Patent number: 7569217Abstract: The present invention relates to the characterization of the porcine adenovirus E1 and E4 regions. The complete nucleotide sequence of the genome of porcine adenovirus type 3 (PAV-3), providing the characterization of the PAV3 E1 region, is described herein. Methods for construction of infectious PAV genomes by homologous recombination in procaryotic cells are provided. Recombinant PAV viruses are obtained by transfection of mammalian cells with recombinant PAV genomes. The PAV-3 genome can be used as a vector for the expression of heterologous nucleotide sequences, for example, for the preparation and administration of subunit vaccines to swine or other mammals.Type: GrantFiled: July 19, 2002Date of Patent: August 4, 2009Assignee: University of SaskatchewanInventor: Suresh K. Tikoo
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Patent number: 7560278Abstract: The present invention relates to methods for culturing circovirus and in particular, porcine circovirus. The present invention provides compositions and methods for culturing porcine circovirus in mammalian cells expressing mammalian adenovirus E1 function.Type: GrantFiled: January 17, 2007Date of Patent: July 14, 2009Assignee: University of SaskatchewanInventors: Qiang Liu, Suresh K. Tikoo, Philip Willson, Lorne A. Babiuk
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Patent number: 7335353Abstract: The complete nucleotide sequence of the genome of porcine adenovirus type 3 (PAV-3) is provided. Methods for construction of infectious PAV genomes by homologous recombination in procaryotic cells are provided. Recombinant PAV viruses are obtained by transfection of mammalian cells with recombinant PAV genomes. The PAV-3 genome can be used as a vector for the expression of heterologous nucleotide sequences, for example, for the preparation and administration of subunit vaccines to swine or other mammals. In addition, PAV-3 vectors can be used for gene therapy and expression of heterologous polypeptides. PAV-3 genome sequences can also be used for diagnostic purposes, to detect the presence of PAV-3 DNA in a subject or biological sample.Type: GrantFiled: September 16, 2002Date of Patent: February 26, 2008Assignee: University of SaskatchewanInventors: Police S. Reddy, Suresh K. Tikoo, Lorne A. Babiuk
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Patent number: 7264818Abstract: The present invention relates to the identification of bovine adenovirus sequence(s) essential for encapsidation and E1 transcriptional control regions. The present invention provides adenovirus expression systems, host cells and compositions comprising adenovirus vectors which comprise one or more BAV sequence(s) essential for encapsidation, as well as helper virus which express BAV sequences essential for encapsidation. The present invention also provides helper vectors comprising a BAV sequence essential for encapsidation which is used in a helper virus for propagating recombinant adenovirus. The present invention also provides adenovirus expression systems, host cells and compositions comprising adenovirus vectors which comprise modifications in BAV E1 transcriptional control regions. The present invention also provides methods for making adenovirus vectors comprising BAV sequence(s) essential for encapsidation as well as modifications in BAV E1 transcriptional control regions.Type: GrantFiled: June 10, 2004Date of Patent: September 4, 2007Assignee: University of SaskatchewanInventors: Suresh K. Tikoo, Li Xing
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Patent number: 7172899Abstract: The present invention relates to methods for culturing circovirus and in particular, porcine circovirus. The present invention provides compositions and methods for culturing porcine circovirus in mammalian cells expressing mammalian adenovirus E1 function.Type: GrantFiled: May 7, 2004Date of Patent: February 6, 2007Assignee: University of SaskatchewanInventors: Qiang Liu, Suresh K. Tikoo, Philip Willson, Lorne A. Babiuk
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Patent number: 6849446Abstract: The present invention provides modified bovine adenoviruses comprising a modification in a capsid protein wherein said protein is associated with adenovirus tropism and wherein said modification is associated with altered tropism. The present invention provides adenovirus vectors and host cells comprising such vectors. The present invention also provides methods of making and using such adenoviruses.Type: GrantFiled: May 31, 2001Date of Patent: February 1, 2005Assignee: University of SaskatchewanInventors: Suresh K. Tikoo, Lorne A. Babiuk, Linong Zhang, Qiaohua Wu
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Publication number: 20040214162Abstract: The present invention provides porcine adenovirus sequence essential for encapsidation and provides adenovirus vectors comprising such sequences. The present invention provides host cells and composition comprising adenovirus vectors comprising porcine adenovirus sequence essential for encapsidation as well as methods for making and using such adenovirus vectors. The present invention discloses porcine adenovirus sequence for E1 transcriptional control and provides porcine adenovirus vectors comprising a modification(s) in the E1 transcriptional control region.Type: ApplicationFiled: July 18, 2003Publication date: October 28, 2004Inventor: Suresh K. Tikoo
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Patent number: 6794163Abstract: The present invention relates to methods for culturing circovirus and in particular, porcine circovirus. The present invention provides compositions and methods for culturing porcine circovirus in mammalian cells expressing mammalian adenovirus E1 functional protein.Type: GrantFiled: March 27, 2002Date of Patent: September 21, 2004Assignee: University of SaskatchewanInventors: Qiang Liu, Suresh K. Tikoo, Philip Willson, Lorne A. Babiuk
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Publication number: 20030143200Abstract: The present invention relates to the characterization of the porcine adenovirus E1 region. The complete nucleotide sequence of the genome of porcine adenovirus type 3 (PAV-3), providing the characterization of the PAV3 E1 region, is described herein. Methods for construction of infectious PAV genomes by homologous recombination in procaryotic cells are provided. Recombinant PAV viruses are obtained by transfection of mammalian cells with recombinant PAV genomes. The PAV-3 genome can be used as a vector for the expression of heterologous nucleotide sequences, for example, for the preparation and administration of subunit vaccines to swine or other mammals.Type: ApplicationFiled: September 24, 2001Publication date: July 31, 2003Inventor: Suresh K. Tikoo
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Publication number: 20030099615Abstract: The present invention relates to the characterization of the porcine adenovirus E1 and E4 regions. The complete nucleotide sequence of the genome of porcine adenovirus type 3 (PAV-3), providing the characterization of the PAV3 E1 region, is described herein. Methods for construction of infectious PAV genomes by homologous recombination in procaryotic cells are provided. Recombinant PAV viruses are obtained by transfection of mammalian cells with recombinant PAV genomes. The PAV-3 genome can be used as a vector for the expression of heterologous nucleotide sequences, for example, for the preparation and administration of subunit vaccines to swine or other mammals.Type: ApplicationFiled: July 19, 2002Publication date: May 29, 2003Inventor: Suresh K. Tikoo
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Publication number: 20020177216Abstract: The present invention relates to methods for culturing circovirus and in particular, porcine circovirus. The present invention provides compositions and methods for culturing porcine circovirus in mammalian cells expressing mammalian adenovirus E1 function.Type: ApplicationFiled: March 27, 2002Publication date: November 28, 2002Inventors: Qiang Liu, Suresh K. Tikoo, Philip Willson, Lorne A. Babiuk
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Publication number: 20020064859Abstract: The invention disclosed herein provides adenovirus vectors comprising introns 5′ to transgenes. Such adenovirus vectors are useful for expression of proteins. Methods of making and using these adenovirus vectors are provided herein. In particular, methods of obtaining increased expression of viral proteins from the adenovirus vectors comprising introns 5′ to transgenes is provided.Type: ApplicationFiled: July 13, 2001Publication date: May 30, 2002Inventor: Suresh K. Tikoo
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Publication number: 20020034519Abstract: The present invention provides modified bovine adenoviruses comprising a modification in a capsid protein wherein said protein is associated with adenovirus tropism and wherein said modification is associated with altered tropism. The present invention provides adenovirus vectors and host cells comprising such vectors. The present invention also provides methods of making and using such adenoviruses.Type: ApplicationFiled: May 31, 2001Publication date: March 21, 2002Inventors: Suresh K. Tikoo, Lorne A. Babiuk, Linong Zhang, Qiaohua Wu