Abstract: Implementations include periodically receiving itinerary data representative of routes, the itinerary data including date, price, and route, for each period and each route: encoding a first portion of the itinerary data using label encoding to provide encoded data, the first portion of the itinerary data including letters, the encoded data including numbers and being absent of letters, converting a second portion of the itinerary data using a mapping to provide converted data, the converted data including a number, training a ML model for a respective route using the encoded data and the converted data, receiving a prediction request including a route and a departure date, retrieving a ML model associated with the route, and generating a prediction result by processing the route and the departure date through the ML model, the prediction result including a set of price-day pairs.

Abstract: The spirooxindole-pyrrolothiazole heterocyclic hybrids are compounds having the formula: wherein R is hydrogen and R? is fluorine (compound 6a) or R is fluorine and R? is hydrogen (compound 6b). The hybrids may be obtained using a chemical synthesis process involving 1,3-dipolar cycloaddition of 3,5-bis(4/2-fluoro-benzylidene) piperidin-4-ones with isatin and 4-thiazolidinecarboxylic acid in a suitable solvent, preferably 1-butyl-3-methyl-imidazolium bromide (“[bmim]Br”), and preferably under microwave irradiation. Both of these new hybrids demonstrate antimicrobial activity against both gram positive and gram negative drug resistant and non-resistant bacterial pathogens, although compound 6a exhibits more potent antibacterial activity than compound 6b.