Abstract: The compounds herein disclosed are N-substituted tetrahydroisoquinoline ethylbenzamide compounds that have modifications on the phenyl rings by introducing groups with various electronic properties. These derivatives of N-substituted tetrahydroisoquinoline ethylbenzamide compounds have been shown to have anti-proliferative activity against cells. In particular, the compounds have been found to be effective in inhibiting the proliferation of cancer cells, such as cancer cells that originated in breast tissue. Additionally, it has been shown that the novel compounds have IC50 values against the breast cancer cells that are 6- to 10-fold less than the IC50 of Tamoxifen.

Abstract: A system and method for monitoring health of equipment. One step of the method includes securing a plurality of sensor modules on to a plurality of pieces of equipment. Each sensor module is secured on to a separate piece of equipment. An additional step includes generating, by each sensor module, sensor data related to the piece of equipment on to which the sensor module is secured. The sensor data includes vibration data for the piece of equipment, temperature data for the piece of equipment, and temperature data for a location exterior to the piece of equipment. An additional step includes processing, by each sensor module, the sensor data generated by the sensor module into a data packet, with the data packet including the sensor data. An additional step includes transmitting the data packet from each sensor module to a gateway over a local communications network. A further step includes transmitting the sensor data from the gateway to a server device.

Abstract: The compounds herein disclosed are N-substituted tetrahydroisoquinoline ethylbenzamide compounds that have modifications on the phenyl rings by introducing groups with various electronic properties. These derivatives of N-substituted tetrahydroisoquinoline ethylbenzamide compounds have been shown to have anti-proliferative activity against cells. In particular, the compounds have been found to be effective in inhibiting the proliferation of cancer cells, such as cancer cells that originated in breast tissue. Additionally, it has been shown that the novel compounds have IC50 values against the breast cancer cells that are 6- to 10-fold less than the IC50 of Tamoxifen.