Patents by Inventor Suresh Mishra

Suresh Mishra has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Transgenic mice expressing Y114F mutant prohibitin
    Patent number: 10036742
    Abstract: The Mito-Ob obese mouse model overexpresses the mitochondrial protein prohibitin (PHB). Mito-Ob male mice develop insulin resistance in addition to obesity and they do not develop overt diabetes. It has been discovered that these mice also spontaneously develop nonalcoholic steatohepatitis (NASH) and hepatocarcinogenesis over time. Also described is a mutant Mito-Ob mouse that develops lymphadenopathy and histiocytosis.
    Type: Grant
    Filed: September 28, 2016
    Date of Patent: July 31, 2018
    Assignee: University of Manitoba
    Inventors: Sudharsana Rao Ande, Khanh Hoa Nguyen, Suresh Mishra
  • Mito-Ob: a transgenic mouse model for obesity
    Patent number: 9781909
    Abstract: An obese mouse model was developed by overexpressing the mitochondrial protein prohibitin (PHB) in white adipose tissue (WAT) specific manner driven by adipocyte protein 2 (aP2) promoter. These mice begin to develop obesity as a result of mitochondrial remodeling (upregulation of mitochondrial biogenesis and function) in WAT.
    Type: Grant
    Filed: July 11, 2014
    Date of Patent: October 10, 2017
    Assignee: University of Manitoba
    Inventors: Sudharsana R. Ande, Suresh Mishra
  • USES OF MITO-OB TRANSGENIC MICE
    Publication number: 20170089888
    Abstract: The Mito-Ob obese mouse model overexpresses the mitochondrial protein prohibitin (PHB). Mito-Ob male mice develop insulin resistance in addition to obesity and they do not develop overt diabetes. It has been discovered that these mice also spontaneously develop nonalcoholic steatohepatitis (NASH) and hepatocarcinogenesis over time. Also described is a mutant Mito-Ob mouse that develops lymphadenopathy and histiocytosis.
    Type: Application
    Filed: September 28, 2016
    Publication date: March 30, 2017
    Inventors: Sudharsana Rao Ande, Khanh Hoa Nguyen, Suresh Mishra
  • Mito-Ob: A Transgenic Mouse Model for Obesity
    Publication number: 20150026833
    Abstract: An obese mouse model was developed by overexpressing the mitochondrial protein prohibitin (PHB) in white adipose tissue (WAT) specific manner driven by adipocyte protein 2 (aP2) promoter. These mice begin to develop obesity as a result of mitochondrial remodeling (upregulation of mitochondrial biogenesis and function) in WAT.
    Type: Application
    Filed: July 11, 2014
    Publication date: January 22, 2015
    Inventors: Sudharsana R. Ande, Suresh Mishra
  • Transglutaminase has intrinsic kinase activity
    Patent number: 7090971
    Abstract: A method of identifying compounds capable of modulating trans-glutaminase (TG) kinase activity is described. The method involves adding a test compound to a mixture of TG and a suitable TG kinase substrate, incubating the mixture under conditions promoting TG kinase activity, and determining if the test compound activates or modulates TG kinase activity as indicated by greater than expected TG-mediated phosphorylation of the TG kinase substrate or if the test compound inhibits TG kinase activity as indicated by lower than expected TG-mediated phosphorylation of the TG kinase substrate as compared to a control comprising TG and a suitable TG kinase substrate incubated under conditions promoting TG kinase activity.
    Type: Grant
    Filed: January 24, 2005
    Date of Patent: August 15, 2006
    Inventors: Suresh Mishra, Liam J. Murphy
  • Transglutaminase has intrinsic kinase activity
    Publication number: 20050208612
    Abstract: A method of identifying compounds capable of modulating trans-glutaminase (TG) kinase activity is described. The method involves adding a test compound to a mixture of TG and a suitable TG kinase substrate, incubating the mixture under conditions promoting TG kinase activity, and determining if the test compound activates or modulates TG kinase activity as indicated by greater than expected TG-mediated phosphorylation of the TG kinase substrate or if the test compound inhibits TG kinase activity as indicated by lower than expected TG-mediated phosphorylation of the TG kinase substrate as compared to a control comprising TG and a suitable TG kinase substrate incubated under conditions promoting TG kinase activity.
    Type: Application
    Filed: January 24, 2005
    Publication date: September 22, 2005
    Inventors: Suresh Mishra, Liam Murphy