Abstract: The present invention provides therapeutic compound for prevention and treatment of primary biliary cholangitis, (PBC). Specifically, the present invention provides pharmaceutical composition comprising a compound of Formula (I) or a pharmaceutically acceptable salt thereof, for the treatment of PBC.

Abstract: Provided is a shaft-less rotating electrical machine that includes a stator supported by a stator frame and a rotor that is mechanically connectable to a shaftline and is positioned radially inside the stator. The electrical machine is prepared for transport and includes a support structure for stably supporting the rotor inside the stator frame and the support structure includes one or more supports that are positioned in the air gap between the stator and the rotor, and one or more transport brackets. The transport brackets are fixedly connected between the stator frame and the rotor.

Abstract: Provided herein are transdermal delivery devices comprising tetrabenazine, a deuterated tetrabenazine, or a combination thereof. Also provided herein are pharmaceutical compositions, such as adhesive compositions, comprising tetrabenazine, a deuterated tetrabenazine, or a combination thereof, for example, homogenously dispersed in an adhesive, such as a pressure sensitive adhesive. Further provided herein are methods of using the transdermal delivery devices or pharmaceutical compositions, for example, for treating a hyperkinetic movement disorder.

Abstract: In some aspects, the techniques described herein relate to a method including: providing, on a peer-to-peer distributed network, an aggregation server; implementing, at a first node of the peer-to-peer distributed network, a machine learning (ML) model, wherein the ML model is trained on a first private data set; sending the ML model to the aggregation server; replicating the ML model to a second node of the peer-to-peer distributed network, wherein the ML model is retrained on a second private data set to generate a retrained model; sending the retrained model to the aggregation server; aggregating the ML model and the retrained model to generate an aggregated model; and replicating the aggregated model to the first node of the peer-to-peer distributed network, wherein the ML model is promoted to a production model at the first node of the peer-to-peer distributed network.

Abstract: Embodiments are directed to managing skill proficiencies. Declared skills may be determined based on a job description and natural language processing (NLP) actions declared in one or more extraction models. An inference prompt for a large language model (LLM) may be generated based on the job description such that the job description and the declared skills may be included in the inference prompt. The LLM may be trained with the inference prompt to generate a response such that the inference prompt may be iteratively updated based on validations of the response. The LLM may be retrained with the updated inference prompt to generate an updated response that includes the inferred skills that may be separate from the declared skills. A job profile that corresponds to the job description may be updated to include the declared skills and the separate inferred skills.

Abstract: Embodiments are directed to managing data for unified graph representation of skills and acumen. Information associated with one or more subjects may be classified to provide profile information that conforms to a unified schema. Fields of the profile information may be classified as facts, fact-relationships, actions, skills, or skill-relationships based on the unified schema. A plurality of profile graphs may be generated based on map models and the facts, the fact-relationships, the actions, the skills, or the skill-relationships such that the map models include one or more directives for associating the facts, the fact-relationships, the actions, the skills, or the skill-relationships with one or more nodes or one or more edges in the plurality of profile graphs. In response to query information provided by one or more analysis applications, classifying a portion of the plurality of profile graphs based on the query information.

Abstract: Embodiments are directed to managing data for unified graph representation of skills and acumen. Information associated with one or more subjects may be classified to provide profile information that conforms to a unified schema. Fields of the profile information may be classified as facts, fact-relationships, actions, skills, or skill-relationships based on the unified schema. A plurality of profile graphs may be generated based on map models and the facts, the fact-relationships, the actions, the skills, or the skill-relationships such that the map models include one or more directives for associating the facts, the fact-relationships, the actions, the skills, or the skill-relationships with one or more nodes or one or more edges in the plurality of profile graphs. In response to query information provided by one or more analysis applications, classifying a portion of the plurality of profile graphs based on the query information.

Abstract: Embodiments are directed to managing courses. Course information for a course may be provided. Skill terms may be determined for the course based on the course information and skill models. Candidate skills may be determined based on the skill terms and a unified skill dictionary such that the skill terms may be mapped to the candidate skills based on the unified skill dictionary. A summary of the course information and the candidate skills may be displayed to a subject matter expert. if the subject matter expert confirms that a candidate skill may be taught by the course, the candidate skill may be associated with a course profile for the course that includes the confirmed candidate skills and proficiency scores for the confirmed skills.

Abstract: Embodiments of the present subject matter provide a biocidal composition comprising an aqueous mixture of (a) a phosphonium compound and (b) a polymeric ammonium compound, wherein the weight ratio of compound (a) to compound (b) is from 0.2:1 to 20:1, and wherein the phosphonium compound (a) has formula: wherein each R is independently a C1-C6 alkyl group which is unsubstituted or substituted by a cyano, hydroxyl, esterified hydroxyl or aryl group; R1 represents a C8-C18 alkyl group which is substituted or unsubstituted; and X represents either chlorine or bromine; and wherein the polymeric ammonium compound (b) comprises the repeat unit: wherein each R2 is independently a C1-C2 alkyl group which is substituted or unsubstituted; R3 represents a C2-C18 alkyl or alkenyl group which is substituted or unsubstituted; and R4 represents a C2-C18 alkyl or alkenyl group which is substituted or unsubstituted, a diethyl ether group, an isopropanol group, a N,N-dipropylurea group, or a 2-butene group.

Abstract: Embodiments of the present subject matter provide a biocidal composition comprising an aqueous mixture of (a) a phosphonium compound and (b) a polymeric ammonium compound, wherein the weight ratio of compound (a) to compound (b) is from 0.2:1 to 20:1, and wherein the phosphonium compound (a) has formula: wherein each R is independently a C1-C6 alkyl group which is unsubstituted or substituted by a cyano, hydroxyl, esterified hydroxyl or aryl group; R1 represents a C8-C18 alkyl group which is substituted or unsubstituted; and X represents either chlorine or bromine; and wherein the polymeric ammonium compound (b) comprises the repeat unit: wherein each R2 is independently a C1-C2 alkyl group which is substituted or unsubstituted; R3 represents a C2-C18 alkyl or alkenyl group which is substituted or unsubstituted; and R4 represents a C2-C18 alkyl or alkenyl group which is substituted or unsubstituted, a diethyl ether group, an isopropanol group, a N,N-dipropylurea group, or a 2-butene group.

Abstract: Compounds of Formula (I) along with processes for their preparation that are useful for treating, managing and/or lessening the diseases, disorders, syndromes or conditions associated with the modulation of cannabinoid (CB) receptors. Methods of treating, managing and/or lessening the diseases, disorders, syndromes or conditions associated with the modulation of cannabinoid (CB) receptors of Formula (I).

Abstract: Compounds of Formula (I) along with processes for their preparation that are useful for treating, managing and/or lessening the diseases, disorders, syndromes or conditions associated with the modulation of cannabinoid (CB) receptors. Methods of treating, managing and/or lessening the diseases, disorders, syndromes or conditions associated with the modulation of cannabinoid (CB) receptors of Formula (I).

Abstract: This invention relates to a slidable button cover that can be attached to a cuff button and/or a shirt button on a shirt of a type comprising a cuff button and/or a shirt button. More specifically, this invention relates to a slidable button cover that can be attached on a shirt of a type comprising a cuff, a shirt, a cuff and/or shirt button and a cuff and/or shirt button hole, said cuff and/or shirt button securely engaging said cuff and/or shirt button, and a slidable button cover with a decorative face on the top of said slidable button cover with an attaching means on the bottom of said slidable button cover capable of sliding over and engaging said cuff and/or shirt button thread, said cuff and/or shirt button resting securely within the attaching means and beneath the bottom of the slidable button cover.

Abstract: Embodiments of the present subject matter provide a biocidal composition comprising an aqueous mixture of (a) a phosphonium compound and (b) a polymeric ammonium compound, wherein the weight ratio of compound (a) to compound (b) is from 0.2:1 to 20:1, and wherein the phosphonium compound (a) has formula: wherein each R is independently a C1-C6 alkyl group which is unsubstituted or substituted by a cyano, hydroxyl, esterified hydroxyl or aryl group; R1 represents a C8-C18 alkyl group which is substituted or unsubstituted; and X represents either chlorine or bromine; and wherein the polymeric ammonium compound (b) comprises the repeat unit: wherein each R2 is independently a C1-C2 alkyl group which is substituted or unsubstituted; R3 represents a C2-C18 alkyl or alkenyl group which is substituted or unsubstituted; and R4 represents a C2-C18 alkyl or alkenyl group which is substituted or unsubstituted, a diethyl ether group, an isopropanol group,a N,N-dipropylurea group, or a 2-butene group.

Abstract: A system and method is described for using areas in or near photo global alignment marks or in or near unpatterned areas of a semiconductor wafer to create structures for secondary ion mass spectroscopy (SIMS) testing or electron beam (E-Beam) testing or X-ray diffraction (XRD) testing of the semiconductor wafer. The present invention makes it possible to obtain wafer level information about the front-end processing of the semiconductor wafers. The SIMS/E-Beam/XRD testing measures characteristics such as the dopant content, thickness variations, and defect density of the wafers. The present invention eliminates the need to build individual test structures within product dies and eliminates the need to build scribe line structures near the product dies.

Abstract: Surfaces of a downhole tool, e.g. a drill bit, a reamer shoe or a stabilizer, are protected by at least temporarily fixing a super-hard material (6) to the surfaces of the down-hole tool, and spray fusing a binding material (2) around the super-hard material to permanently bind the super-hard material to the down hole tool.

Abstract: A composition for treating an aqueous system to inhibit deposition of scale caused by scale-forming impurities in the system which comprises (A) a hydrolysed homopolymer of maleic anhydride having a weight average molecular weight of 400 to 800 or a water-soluble salt thereof and (B) a carboxyl-containing acrylic polymer having a weight average molecular weight of 800 to 9500 selected from a polyacrylic acid, a polymethacrylic acid, a copolymer of at least two acrylic monomers, one of the monomers being acrylic acid of methacrylic acid, a copolymer of acrylic acid or methacrylic acid with a vinyl carboxylate or a styrene, a phosphinoacrylic acid telomer or a phosphinomethacrylic acid telomer, of a water-soluble salt of the carboxyl-containing acrylic polymer.

Abstract: The present invention provides a process for treating water or an aqueous system to prevent the deposition of scale caused by scale-forming impurities in the water which comprises hydrolyzed polymaleic anhydride and a hydrolyzed copolymer of maleic anhydride with at least one mono-ethylenically unsaturated monomer.