Abstract: The present invention provides a reproxalap ophthalmic solution, and methods of using the same for treating a disease or disorder such as allergic conjunctivitis.

Abstract: The present disclosure provides methods and reagents for the diagnosis, prognosis or the monitoring of breast cancer, including various subtypes of breast cancer including, for example, estrogen receptor (ER) negative breast cancer, ER positive breast cancer, triple negative breast cancer (TNBC) and other subtypes of breast cancer.

Abstract: An approach to improving system availability. Availability data for individual resources may be obtained from configuration templates and stored in an Availability Graph. The graph is traversed to calculate availability statistics at a grouped component and at an overall architecture level and grouping components level. Revisions may be made to enhance overall availability levels, and the revised Availability Graph can also be exported as an implementable configuration file. As a result, this solution provides a structured way to detect and resolve availability bottlenecks.

Abstract: An approach to improving system availability. Availability data for individual resources may be obtained from configuration templates and stored in an Availability Graph. The graph is traversed to calculate availability statistics at a grouped component and at an overall architecture level and grouping components level. Revisions may be made to enhance overall availability levels, and the revised Availability Graph can also be exported as an implementable configuration file. As a result, this solution provides a structured way to detect and resolve availability bottlenecks.

Abstract: The present disclosure generally relates to methods and reagents for the diagnosis, prognosis or the monitoring of estrogen receptor 1 (ESR1) positive breast cancer, for example, ESR1 positive breast cancer which is responsive to endocrine therapy and/or ESR1 positive breast cancer which is refractory to endocrine therapy. The present disclosure also relates generally to treatment management of ESR1 positive breast cancer.

Abstract: The present disclosure provides methods and reagents for the diagnosis, prognosis or the monitoring of breast cancer, including various subtypes of breast cancer including, for example, estrogen receptor (ER) negative breast cancer, ER positive breast cancer, triple negative breast cancer (TNBC) and other subtypes of breast cancer.

Abstract: The present invention provides methods for diagnosing cancer (such as ovarian, breast, or colon cancer) or a predisposition thereto in a subject, for monitoring the efficacy of treatment of a subject suffering from cancer, or for determining the likelihood of survival of a subject suffering from cancer, comprising detecting modified chromatin (such as DNA methylation) within a locus of the LOC134466 gene in a sample taken from the subject. The invention further provides kits for use in these methods, and methods of treating subjects based on a diagnosis performed using the methods of the invention.

Abstract: An indexing system for a book, the system comprising an enclosure for the book, the enclosure having a back wall and a top wall capable of pivoting relative to the back wall. The top wall carries a scale with a displaceable slide and the scale carries indications that correspond to specific pages in the book. The system also includes plurality of book tabs adapted to be attached to specific pages of the book. The slide is attached to at least one arm that includes a lug adapted to engage a tab. Actuation means cause the lug to move from a disengaged to an engaged position in which the lug engages the tab, whereby displacement of the slide to a selected page causes the arm and lug to be positioned adjacent a selected tab and activation of the actuation means causes the lug to assume the engaged position with the selected tab so that when the top wall is pivoted open the book is opened at the selected page.

Abstract: A diagnostic or prognostic assay is disclosed for a disease of condition characterized by abnormal methylation of cytosine at side or sites within the glutathione-S-transferase (GST) Pi gene and/or its regulatory flanking sequences (e.g., prostate cancer and liver cancer). The assay comprises: (i) isolating DNA from said subject, and (ii) determining (e.g., by selective PCR amplification) the presence of abnormal methylation of cytosine at a site or sites within the GST-Pi gene and/or its regulatory flanking sequences.

Abstract: The present invention relates to an arrangement for storing at least photographic prints. The arrangement of the present invention is in the form of an envelope or wallet-type member and includes a tab arrangement which permits a user to customize the location of the tabs on the wallet-type member. The tab arrangement comprises removable tabs on the wallet-type member which provides a customer with the opportunity to chose which tab is to be used for providing identifying information on the envelope. Further, the wallet-type member includes a planar member which is adapted to have an opening to reveal an index print or a photographic print representative of the prints stored in the wallet-type member. The opening and the tab or tabs are provided on the same side or the same planar member of the wallet-type member so as to enable the viewing of both the tab or tabs and the displayed index or photographic print at the same time.

Abstract: A system for utility garments, the garment shells for these garments, and the pockets moutable upon these garments, which provide the wearer the option of removing pockets and discarding the garment for disposal or cleaning while not having to remove the contents of the pockets. The pockets may have one or more compartments to place items needed by the wearer during use.

Abstract: A system for utility garments provides the wearer of a variety of garments including blazers, lab coats, and vests with the option of removing pockets and discarding the garment for disposal or cleaning, while not having to remove the contents of the pockets. The wearers who would benefit from such garments include medical workers. The pockets may have one or more compartments to place items needed by the wearer during use. In one embodiment the pockets or the garment or both may be disposable to prevent spread of infection and similar problems.

Abstract: The present invention relates to an arrangement for storing at least photographic prints. The arrangement of the present invention is in the form of an envelope or wallet-type member and includes a tab arrangement which permits a user to customize the location of the tabs on the wallet-type member. The tab arrangement comprises removable tabs on the wallet-type member which provides a customer with the opportunity to chose which tab is to be used for providing identifying information on the envelope. Further, the wallet-type member includes a planar member which is adapted to have an opening to reveal an index print or a photographic print representative of the prints stored in the wallet-type member. The opening and the tab or tabs are provided on the same side or the same planar member of the wallet-type member so as to enable the viewing of both the tab or tabs and the displayed index or photographic print at the same time.

Abstract: A disposable or washable car seat or other seat liner that may include: Version A being a) generally rectangular shape approximately 20″×40″ and ⅜″ in thickness; b) sheet material having top surface of an absorbent material, an optional middle layer of absorbent filler, and a bottom surface of non-permeable material; c) having several points of reduced strength and reduced thickness scored by heat or pressure at 2 or more points at the upper middle, 1 or more points at the lower middle, 1 or more points on left and right sides of middle, and 1 or more points on the left and right sides of upper, outer edges.

Abstract: A functionally coordinated nursing slip and nursing bra enable a working mother to breast feed her infant without having to make any indecorous motions that attract unwanted attention, in order to adjust her nursing undergarments. This is accomplished without affecting the stylishness, strap adjustability, or concealment otherwise provided by the slip. Similarly, the functionality of the nursing bra is not reduced. The coordination arrangement allows the opened slip to be fully supported by the nursing bra. The opened slip parts are retained handily by the coordinated bra so that reclosure is easily done. Thus all need for the mother to seek total privacy in nursing is eliminated, and she can nurse around other persons with minimal embarassment.

Abstract: A padded frame and method for making the same from decorative covering material and mounting board having an adhesive surface on one side thereof and a foam sponge material secured to the other.