Abstract: Patients diagnosed with a cancer harboring an IDH-1 mutation can be treated by the administration of a therapeutically effective amount of a pharmaceutical composition comprising Compound 1, a selective inhibitor of 2-HG production from mIDH-1 enzymes including the R132 mutations R132C, R132H, R132L, R132G, and R132S.

Abstract: Patients diagnosed with a cancer harboring an IDH-1 mutation can be treated by the administration of a therapeutically effective amount of a pharmaceutical composition comprising Compound 1, a selective inhibitor of 2-HG production from mIDH-1 enzymes including the R132 mutations R132C, R132H, R132L, R132G, and R132S.

Abstract: A gathering and dispensing scoop with agitating gate valve provides a hemispherically shaped scoop body defining an upper opening, a bottom opening, and a channel extending therebetween. A handle extends radially from an outer peripheral surface of the scoop body. A sector shaped gate valve transects the channel and has a user operable finger tab adjacent to the handle for a user to pivot the gate valve from a first position obstructing the bottom opening to a second position wherein the gate valve no longer obstructs the channel and opens the bottom opening.

Abstract: A gathering and dispensing scoop with agitating gate valve provides a scoop body defining an upper opening, a bottom opening, and a channel extending therebetween. A handle extends radially from an outer peripheral surface of the scoop body. A gate valve transects the channel and has a user operable finger tab adjacent to the handle for a user to move the gate valve from a first position transecting the channel and obstructing the bottom opening to a second position wherein the gate valve no longer obstructs the channel and opens the bottom opening.

Abstract: A gathering and dispensing scoop with agitating gate valve provides a scoop body defining an upper opening, a bottom opening, and a channel extending therebetween. A handle extends radially from an outer peripheral surface of the scoop body. A gate valve transects the channel and has a user operable finger tab adjacent to the handle for a user to move the gate valve from a first position transecting the channel and obstructing the bottom opening to a second position wherein the gate valve no longer obstructs the channel and opens the bottom opening.

Abstract: A gathering and dispensing scoop with agitating gate valve provides a hemispherically shaped scoop body defining an upper opening, a bottom opening, and a channel extending therebetween. A handle extends radially from an outer peripheral surface of the scoop body. A sector shaped gate valve transects the channel and has a user operable finger tab adjacent to the handle for a user to pivot the gate valve from a first position obstructing the bottom opening to a second position wherein the gate valve no longer obstructs the channel and opens the bottom opening.

Abstract: A gathering and dispensing scoop with agitating gate valve provides a scoop body defining an upper opening, a bottom opening, and a channel extending therebetween. A handle extends radially from an outer peripheral surface of the scoop body. A gate valve transects the channel obstructing the bottom opening and has a user operable finger tab adjacent to the handle.

Abstract: A gathering and dispensing scoop with agitating gate valve provides a scoop body defining an upper opening, a bottom opening, and a channel extending therebetween. A handle extends radially from an outer peripheral surface of the scoop body. A gate valve transects the channel obstructing the bottom opening and has a user operable finger tab adjacent to the handle.

Abstract: A protocol, method, apparatus and computer program product for providing and utilizing a host credential authorization protocol (HCAP) is presented. The protocol is utilized by an AAA server and a posture validation server. The AAA server and the posture validation server are utilized to determine whether a host is allowed access to a device.

Abstract: A process for extracting from aqueous solution the alkali metal or calcium salt of a halo or haloalkyl substituted 2-hydroxypyridine, or a 2-hydroxyquinoline or 2-hydroxybenzothiazole which comprises contacting an aqueous alkaline or neutral solution of the alkali metal or calcium salt, in which is dissolved an alkali metal fluoride, chloride, bromide, hydroxide, sulphate, sulphite, cyanate, cyanide, thiocyanate, thiosulphate, sulphide, phosphate, hydrogen phosphate, carbonate, bicarbonate, borate, chlorate, hypochlorite, perchlorate, nitrite, chromate, dichromate or permanganate or calcium chloride, bromide, nitrate, nitrite, chlorate, hypochlorite, perchlorate, thiocyanate, thiosulphate, chromate, dichtromate or permanganate, with a partially water-miscible organic solvent so as to transfer aqueous solution of the alkali metal or calcium salt of the 2-hydroxypyridine, 2-hydroxyquinoline or 2-hydroxybenzothiasole into the solvent whilst retaining separate aqueous and solvent phases, and thereafter separating

Abstract: A protocol, method, apparatus and computer program product for providing and utilizing a host credential authorization protocol (HCAP) is presented. The protocol is utilized by an AAA server and a posture validation server. The AAA server and the posture validation server are utilized to determine whether a host is allowed access to a device.

Abstract: A process for extracting from aqueous solution the alkali metal or calcium salt of a halo or haloalkyl substituted 2-hydroxypyridine, or a 2-hydroxyquinoline or 2-hydroxybenzothiazole which comprises contacting an aqueous alkaline or neutral solution of the alkali metal or calcium salt, in which is dissolved an alkali metal fluoride, chloride, bromide, hydroxide, sulphate, sulphite, cyanate, cyanide, thiocyanate, thiosulphate, sulphide, phosphate, hydrogen phosphate, carbonate, bicarbonate, borate, chlorate, hypochlorite, perchlorate, nitrite, chromate, dichromate or permanganate or calcium chloride, bromide, nitrate, nitrite, chlorate, hypochlorite, perchlorate, thiocyanate, thiosulphate, chromate, dichtromate or permanganate, with a partially water-miscible organic solvent so as to transfer aqueous solution of the alkali metal or calcium salt of the 2-hydroxypyridine, 2-hydroxyquinoline or 2-hydroxybenzothiazole into the solvent whilst retaining separate aqueous and solvent phases, and thereafter separating

Abstract: A dispensing device is adapted for release of a measured quantity of granular material. A base is generally disk-shaped. A stop is carried by an upper surface of the base, and is adjustably positionable so that when a container to be filled is moved into contact with the stop, that container is correctly positioned. A body is attached to a support ledge defined about the perimeter of the base. The body is generally cylindrical, and defines an interior cavity with access through a front opening and a circular top defining an off-center hole. A slide is supported by the top, and is manually movable between a loading position wherein a spring biasing the slide is stressed, and a dispensing position wherein the spring is relaxed. A slide enclosure is attached to the upper rim of the body portion. An input funnel provides a larger upper circular rim and a smaller lower circular rim which is concentric with the upper rim when viewed from the end.

Abstract: A dispensing device is adapted for one-handed operation, and for release of a measured quantity of granular material. A base is generally disk-shaped. A stop is carried by an upper surface of the base, and is adjustably positionable so that when a container to be filled is moved into contact with the stop, that container is correctly positioned. A body 40 is attached to a support ledge defined about the perimeter of the base. The body is generally cylindrical, and defines an interior cavity with access through a front opening and a circular top having an off-center hole. A slide is supported by the top, and is manually movable between a loading position wherein a spring arm biasing the slide is relaxed, and a dispensing position wherein the spring arm is stressed. A slide enclosure is attached to the upper rim of the body portion.

Abstract: An apparatus for performing 3-dimensional antibiotic susceptibility tests includes a plate with culture medium thereon, the plate rotatably mounted to a support for selective rotation. A knife is located to cut a slit in the culture medium as the plate is rotated, with a dispensing stylus located to dispense inoculum into the slit formed by the knife. A wedge apparatus is mounted adjacent the plate with a wedge-shaped leg depending into the culture medium so as to compress the culture medium towards the center of the plate, to thereby force the walls of the slit together after the inoculum has been deposited within the slit. A method for performing modified 3-dimensional antibiotic susceptibility tests includes the step of uniformly spreading a test microorganism over the top surface of culture medium on a plate. A slit is then formed in the culture medium and a uniform stream of suspending medium with a test microorganism therein is dispensed in and along the length of the slit.