Abstract: The present invention provides methods and compositions of treating Friedreich's ataxia (FRDA) based on administering an mRNA encoding a frataxin protein.

Abstract: The present invention provides methods and compositions of treating Friedreich's ataxia (FRDA) based on administering an mRNA encoding a frataxin protein.

Abstract: Methods and systems for assessing lung function using volumetric images obtained at inspiration and expiration. The method may include processing the first and second set of images to identify known anatomical structures of the lungs, registering the first set of images to the second set of images to match voxels of the first set of images to voxels of the second set of images as matched pairs of inspiratory and expiratory voxels, calculating a continuous probability of a lung characteristic at a location of the matched pairs of voxels, and displaying the result on a display. The method may also include classifying lung tissue at each location as normal, having air trapping without emphysema, or being emphysematous.

Abstract: The present invention provides methods and compositions of treating Friedreich's ataxia (FRDA) based on administering an mRNA encoding a frataxin protein.

Abstract: Methods and systems for assessing lung function using volumetric images obtained at inspiration and expiration. The method may include processing the first and second set of images to identify known anatomical structures of the lungs, registering the first set of images to the second set of images to match voxels of the first set of images to voxels of the second set of images as matched pairs of inspiratory and expiratory voxels, calculating a continuous probability of a lung characteristic at a location of the matched pairs of voxels, and displaying the result on a display. The method may also include classifying lung tissue at each location as normal, having air trapping without emphysema, or being emphysematous.

Abstract: Methods and systems for assessing lung function using volumetric images obtained at inspiration and expiration. The method may include processing the first and second set of images to identify known anatomical structures of the lungs, registering the first set of images to the second set of images to match voxels of the first set of images to voxels of the second set of images as matched pairs of inspiratory and expiratory voxels, calculating a continuous probability of a lung characteristic at a location of the matched pairs of voxels, and displaying the result on a display. The method may also include classifying lung tissue at each location as normal, having air trapping without emphysema, or being emphysematous.

Abstract: Systems and methods for visualizing pulmonary fissures including a processor and software instructions for creating a 3 dimensional model of the fissures. Creating the 3 dimensional model includes accessing volumetric imaging data of the patient's lungs, analyzing the volumetric imaging data to segment the lungs into lobes, using the segmented lobes to identify locations at which pulmonary fissures should be present where the lobes abut each other, analyzing the volumetric images to identify locations at which pulmonary fissures actually are present as existing fissure, comparing the locations at which pulmonary fissures should be present to the locations at which pulmonary fissures are present to identify locations of missing fissure, and creating a visual display comprising a 3 dimensional model of the pulmonary fissures including existing fissure portions and missing fissure portions, with the existing fissure portion visually distinct from the missing fissure portions.

Abstract: Methods and systems for assessing lung function using volumetric images obtained at inspiration and expiration. The method may include processing the first and second set of images to identify known anatomical structures of the lungs, registering the first set of images to the second set of images to match voxels of the first set of images to voxels of the second set of images as matched pairs of inspiratory and expiratory voxels, calculating a continuous probability of a lung characteristic at a location of the matched pairs of voxels, and displaying the result on a display. The method may also include classifying lung tissue at each location as normal, having air trapping without emphysema, or being emphysematous.

Abstract: Systems and methods for visualizing pulmonary fissures including a processor and software instructions for creating a 3 dimensional model of the fissures. Creating the 3 dimensional model includes accessing volumetric imaging data of the patient's lungs, analyzing the volumetric imaging data to segment the lungs into lobes, using the segmented lobes to identify locations at which pulmonary fissures should be present where the lobes abut each other, analyzing the volumetric images to identify locations at which pulmonary fissures actually are present as existing fissure, comparing the locations at which pulmonary fissures should be present to the locations at which pulmonary fissures are present to identify locations of missing fissure, and creating a visual display comprising a 3 dimensional model of the pulmonary fissures including existing fissure portions and missing fissure portions, with the existing fissure portion visually distinct from the missing fissure portions.

Abstract: Systems and methods for visualizing pulmonary fissures including a processor and software instructions for creating a 3 dimensional model of the fissures. Creating the 3 dimensional model includes accessing volumetric imaging data of the patient's lungs, analyzing the volumetric imaging data to segment the lungs into lobes, using the segmented lobes to identify locations at which pulmonary fissures should be present where the lobes abut each other, analyzing the volumetric images to identify locations at which pulmonary fissures actually are present as existing fissure, comparing the locations at which pulmonary fissures should be present to the locations at which pulmonary fissures are present to identify locations of missing fissure, and creating a visual display comprising a 3 dimensional model of the pulmonary fissures including existing fissure portions and missing fissure portions, with the existing fissure portion visually distinct from the missing fissure portions.

Abstract: The present invention is directed to methods and compositions for accomplishing systemic delivery of minimally-soluble bioactive agents such as, but not limited to, proteins of the TGF-? superfamily via a peripheral mode of administration. According to the invention, an exemplary bioactive agent is BMP-7. The invention further provides for minimally-invasive systemic treatment of skeletal disorders such as osteoporosis as well as minimally-invasive systemic treatment of injured or diseased non-mineralized tissues and organs such kidneys. Practice of the invention eliminates adverse side effects at the peripheral site of intravenous administration of the bioactive agent.

Abstract: The present invention is directed to methods and compositions for accomplishing systemic delivery of minimally-soluble bioactive agents such as, but not limited to, proteins of the TGF-? superfamily via a peripheral mode of administration. According to the invention, an exemplary bioactive agent is BMP-7. The invention further provides for minimally-invasive systemic treatment of skeletal disorders such as osteoporosis as well as minimally-invasive systemic treatment of injured or diseased non-mineralized tissues and organs such kidneys. Practice of the invention eliminates adverse side effects at the peripheral site of intravenous administration of the bioactive agent.

Abstract: Systems and methods for visualizing pulmonary fissures including a processor and software instructions for creating a 3 dimensional model of the fissures. Creating the 3 dimensional model includes accessing volumetric imaging data of the patient's lungs, analyzing the volumetric imaging data to segment the lungs into lobes, using the segmented lobes to identify locations at which pulmonary fissures should be present where the lobes abut each other, analyzing the volumetric images to identify locations at which pulmonary fissures actually are present as existing fissure, comparing the locations at which pulmonary fissures should be present to the locations at which pulmonary fissures are present to identify locations of missing fissure, and creating a visual display comprising a 3 dimensional model of the pulmonary fissures including existing fissure portions and missing fissure portions, with the existing fissure portion visually distinct from the missing fissure portions.

Abstract: The present invention is directed to methods and compositions for accomplishing systemic delivery of minimally-soluble bioactive agents such as, but not limited to, proteins of the TGF-? superfamily via a peripheral mode of administration. According to the invention, an exemplary bioactive agent is BMP-7. The invention further provides for minimally-invasive systemic treatment of skeletal disorders such as osteoporosis as well as minimally-invasive systemic treatment of injured or diseased non-mineralized tissues and organs such kidneys. Practice of the invention eliminates adverse side effects at the peripheral site of intravenous administration of the bioactive agent.

Abstract: A serving dish, such as in the form of a bowl is provided including an upper receptacle and a lower enclosure. The upper receptacle, in the form of a basin, supports a food item to be served frozen, such as ice cream. The lower enclosure, in the form of a stand, includes an interior containing a thermal mass therein. Materials forming the basin have a higher than average thermal conductivity, to relatively rapidly conduct heat away from chilled food items served within the basin. The thermal mass within the interior of the stand has a higher than average specific heat. When the stand and included thermal mass are pre-chilled, large amounts of heat can be rapidly conducted from food items within the basin, down into the thermal mass. Food items served within the basin of the bowl can thus be kept frozen during a serving period.

Abstract: The present invention is directed to methods and compositions for accomplishing systemic delivery of minimally-soluble bioactive agents such as, but not limited to, proteins of the TGF-? superfamily via a peripheral mode of administration. According to the invention, an exemplary bioactive agent is BMP-7. The invention further provides for minimally-invasive systemic treatment of skeletal disorders such as osteoporosis as well as minimally-invasive systemic treatment of injured or diseased non-mineralized tissues and organs such kidneys. Practice of the invention eliminates adverse side effects at the peripheral site of intravenous administration of the bioactive agent.

Abstract: Methods and systems for displaying a volumetric model of a patient's lung including sublobar regions. The system may include a processor and software operable on the processor to receive data from multi-dimensional images of the patient's lungs, such as CT images, and produce data for creation of a volumetric model of the patient's lungs, including sublobar regions, on a graphical user interface. The system may also display the multi-dimensional images on the graphical user interface. A user may select an airway location in the airways on the volumetric model or a multi-dimensional image on the graphical user interface and the portion of the lung distal to the selected location, which may be a sublobe, may be highlighted and/or characterized by the system.

Abstract: The present invention is directed to methods and compositions for accomplishing systemic delivery of minimally-soluble bioactive agents such as, but not limited to, proteins of the TGF-? superfamily via a peripheral mode of administration. According to the invention, an exemplary bioactive agent is BMP-7. The invention further provides for minimally-invasive systemic treatment of skeletal disorders such as osteoporosis as well as minimally-invasive systemic treatment of injured or diseased non-mineralized tissues and organs such kidneys. Practice of the invention eliminates adverse side effects at the peripheral site of intravenous administration of the bioactive agent.

Abstract: A computer-aided diagnostic method and system provide image annotation information that can include an assessment of the probability, likelihood or predictive value of detected or identified suspected abnormalities as an additional aid to the radiologist. More specifically, probability values, in numerical form and/or analog form, are added to the locational markers of the detected and suspected abnormalities. The task of a physician using such a system as disclosed is believed to be made easier by displaying markers representing different regions of interest.

Abstract: A syrup for a frozen carbonated beverage has a freezing point suppressant, which can be a sugar or sugar substitute mixed with sucralose. The syrup contains a gelling agent, a foaming agent and an acidic agent that facilitate forming a slushy frozen beverage suitable of being dispensed from a mechanical beverage dispenser having a mixing and chilling chamber after being mixed with carbon dioxide.