Abstract: The invention relates to cancer, and in particular to novel pharmaceutical compositions, therapies and methods for treating, preventing or ameliorating cancer, and especially metastatic disease. The invention also relates to diagnostic and prognostic methods for cancer and metastatic disease, and biomarkers for these conditions.

Abstract: The invention relates to cyclic polypeptides derived from the C-terminus of acetylcholinesterase for use in treating or preventing cancer or metastatic disease.

Abstract: The invention relates to antibodies, and in particular, to antibodies used in the diagnosis and treatment of neurodegenerative disorders, such as Alzheimer's disease and Parkinson's disease. The invention extends to methods of diagnosis and therapy of neurodegenerative disorders, and to assays and screens for isolating novel therapeutic compounds for treating such diseases.

Abstract: The invention relates to novel peptides, compositions, therapies and methods for treating neurodegenerative disorders, for example Alzheimer's disease.

Abstract: The invention relates to cyclic polypeptides derived from the C-terminus of acetylcholinesterase for use in treating or preventing cancer or metastatic disease.

Abstract: The invention relates to cyclic polypeptides derived from the C-terminus of acetylcholinesterase for use in treating or preventing cancer or metastatic disease.

Abstract: The invention relates to antibodies, and in particular, to antibodies used in the diagnosis and treatment of neurodegenerative disorders, such as Alzheimer's disease and Parkinson's disease. The invention extends to methods of diagnosis and therapy of neurodegenerative disorders, and to assays and screens for isolating novel therapeutic compounds for treating such diseases.

Abstract: The invention relates to cyclic polypeptides derived from the C-terminus of acetylcholinesterase for use in treating or preventing cancer or metastatic disease.

Abstract: The invention relates to novel peptides, compositions, therapies and methods for treating neurodegenerative disorders, for example Alzheimer's disease.

Abstract: There is provided an in vitro screening method for compounds with anaesthetic property, which can distinguish anaesthetics from analgesics and relies on observing the ability of compounds to prolong the duration of transient working neuronal assemblies as may be generated, for example, in in vitro hippocampal slices and observed by optical imaging employing a voltage sensitive fluorescent dye.

Abstract: The acetylcholinesterase 14-mer peptide AEFHRWSSYMVHWK acts alone or in synergism with 2-amyloid to contribute to neuronal degeneration, e.g. in Parkinson's and Alzheimer's diseases, perhaps by exerting calcium channel opening activity. Antibodies and other compounds which inhibit the biological activity are useful for prophylaxis or treatment.

Abstract: The present invention relates to screening assays for functional analogues and antagonists of a polypeptide fragment of acetylcholinesterase (AChE), which is believed to exhibit activity corresponding to non-enzymatic function of AchE in the brain. These assays stem from linkage of such non-enzymatic activity with a target site on the homomeric alpha 7 nicotinic receptor. Antagonists thus identified which are capable of formulation for passage through the blood-brain barrier may be advantageous therapeutic agents for the treatment of a number of neurodegenerative diseases, in particular Alzheimer's Disease, Parkinson's Disease and Motor Neuron Disease.

Abstract: The present invention provides animal models for neurodegenerative diseases, in particular, for example, Alzheimer's Disease, which rely on introduction into the brain of a biologically active fragment of acetylcholinesterase of sequence AEFHRWSSYMVHWK (SEQ. ID no.1), or an active variant thereof, to produce brain lesions.

Abstract: The acetylcholinesterase 14-mer peptide AEFHRWSSYMVHWK acts alone or in synergism with 2-amyloid to contribute to neuronal degeneration, e.g. in Parkinson's and Alzheimer's diseases, perhaps by exerting calcium channel opening activity. Antibodies and other compounds which inhibit the biological activity are useful for prophylaxis or treatment.