Abstract: A method of extracting a substance comprising the steps of: placing a substrate on which a substance has been adsorbed into a container; feeding a solvent into the container whilst restricting its exit to achieve a predetermined pressure of the solvent in the container, wherein the solvent has a critical point and the predetermined pressure is above the critical point of the solvent; releasing the solvent and an extract comprising extracted substances into a separator; reducing the temperature and pressure in the separator to remove a gaseous portion of the solvent from the extract; collecting the extract remaining from the separator.

Abstract: The present invention relates to a method of capturing and stabilising volatile thiol malodour generated on the human skin, comprising steps of: i) contacting the human skin with a substrate, ii) absorbing said thiol into the substrate, and iii) reacting said thiol with a thiol-capture agent. The invention also relates to a method of quantifying said thiol, a method of assessing the deodorizing performance of a cosmetic composition on the human skin.

Abstract: The present invention relates to a method of capturing and stabilising volatile thiol malodour generated on the human skin, comprising steps of: i) contacting the human skin with a substrate, ii) absorbing said thiol into the substrate, and iii) reacting said thiol with a thiol-capture agent. The invention also relates to a method of quantifying said thiol, a method of assessing the deodorizing performance of a cosmetic composition on the human skin.

Abstract: A method for mapping sweat production from the human skin, said method comprising the application of a polydiacetylene (PDA) prepared from a derivative of a conjugated diynoic acid having at least 18 carbon atoms, wherein the PDA changes colour when exposed to sweat, but does not change colour when exposed to pure water.

Abstract: A method of sampling volatile malodorous materials, said method comprising the topical application of a patch comprising an absorbent hydrogel layer and a backing sheet adhering to it, the volatile malodourous materials being absorbed into the hydrogel layer and subsequently extracted from it.

Abstract: A patch and method for capturing perspiration, the patch comprising an absorbent hydrogel layer and a backing sheet adhering to it, the patch preferably comprising a permeable inner membrane and/or a benefit agent embedded in the hydrogel layer.

Abstract: The invention provides a system suitable for monitoring the usage of a toothbrush, the system comprising: (a) a toothbrush; (b) a sound sensor which is located in or on the toothbrush; (c) a programmable data logger which is located in or on the toothbrush, the data logger incorporating a motion sensor and a data store for the logging of data; (d) switching means for triggering the operation of the sound sensor in response to initial signals of toothbrush motion generated by the motion sensor, and (e) a data analysis device which is adapted to analyze data transmitted or acquired from the system to provide information about tooth brushing behavior; in which the duration of data logging is controllable in response to the combined signals received from the sound sensor and the motion sensor respectively.

Abstract: A method of monitoring tooth brushing comprising: receiving a position signal from a position sensor (601) disposed on a toothbrush (21) comprising a handle and a head (22); receiving a force signal from a force sensor (602) disposed on the toothbrush (21); and calculating a position of the head of the toothbrush using the position signal in combination with the force signal.

Abstract: The invention provides a system suitable for monitoring the usage of a toothbrush, the system comprising: (a) a toothbrush; (b) a sound sensor which is located in or on the toothbrush; (c) a programmable data logger which is located in or on the toothbrush, the data logger incorporating a motion sensor and a data store for the logging of data; (d) switching means for triggering the operation of the sound sensor in response to initial signals of toothbrush motion generated by the motion sensor, and (e) a data analysis device which is adapted to analyse data transmitted or acquired from the system to provide information about tooth brushing behaviour; in which the duration of data logging is controllable in response to the combined signals received from the sound sensor and the motion sensor respectively.

Abstract: A method of generating a model of a real object derived from a model of a second object, the model of the second object being defined by an array of data points, a number of identifiable components and a number of further components, comprises measuring parameters of corresponding identifiable components of a real object corresponding to the identifiable components in the model the second object. An array of data points defining a first model of the real object is generated the measured parameters.

Abstract: A method of monitoring tooth brushing comprising: receiving a position signal from a position sensor (601) disposed on a toothbrush (21) comprising a handle and a head (22); receiving a force signal from a force sensor (602) disposed on the toothbrush (21); and calculating a position of the head of the toothbrush using the position signal in combination with the force signal.

Abstract: A method of generating a model of a real object derived from a model of a second object, the model of the second object being defined by an array of data points, a number of identifiable components and a number of further components, comprises measuring parameters of corresponding identifiable components of a real object corresponding to the identifiable components in the model the second object. An array of data points defining a first model of the real object is generated the measured parameters.

Abstract: A method of mapping color space with chromatic formulations, comprising the steps of (a) selecting a limited number of chromatics for use with a bulk material using selection criteria; (b) formulating the selected chromatics with white or black in the bulk material to generate a plurality of chromatic formulations, wherein such plurality of chromatic formulations populate a desirable volume of color space; and (c) computing additional chromatic formulations using algorithms reflecting the contributions of chromatics, white, and black to color, and incremental substitutions thereof. Optional steps in the method are also disclosed. The result can be a database of generated nodes and computed nodes filling desired regions or even the entirety of color space for a given polymeric bulk material. Usefulness includes the ability create, store and communicate chromatic formulations for the generated nodes, the computed nodes, or both for use anywhere in the world via electronic commerce of color matching.

Abstract: This invention provides for a novel ATP-binding cassette protein which is responsible for cytotoxin resistance. The invention also provides for methods of expressing the protein and assays for identification of inhibitors of the protein.

Abstract: The present invention provides a therapeutic agent of kidney cancer, which comprises FK228 of the formula (I) or a salt thereof. FK228 or a salt thereof, which is an active ingredient in the present invention, shows a superior antitumor activity in vivo against kidney cancer.

Abstract: A system and a method are provided for matching the color of a target sample at a remote location. The system has a first computer that is operative to receive and transmit target spectral data at a first location. A second computer in the system is located at a second location remote from the first computer. The second computer is operative to receive the target spectral data or formula identifier from the first computer. The system includes a database including a plurality of data sets. Each data set has at least spectral data corresponding to standard samples. The system also has software capable of searching the database using the target spectral data as search criteria and returning a match with a data set having standard spectral data that matches the target spectral data. The system optionally has a device that can sense the target spectral data of the target sample and input that target spectral data into the first computer, optionally also non-spectral data and QC capability.

Abstract: This invention provides methods that are useful for inhibiting a MXR transporter in a cell overexpressing a MXR gene but not overexpressing a Pgp gene by contacting the cell with an acridine derivative. The invention also provides for a method of treating a mammal suffering from a cancer, which overexpressing a MXR gene but not overexpress a Pgp gene, by the co-administration of a chemotherapeutic and an acridine derivative.

Abstract: The present invention is a method of treatment for a patient with cancer. In particular, it is a method of treating patients having lymphomas and breast cancer using the microtubule agent, Taxol. The present method of administration, serves to prevent or retard the adverse side effects associated with Taxol and reduces the chances of a patient developing mdr Taxol resistance. The novel method of treatment provides a low-dose, long-term exposure to Taxol in a patient.