Patents by Inventor Susan Chubinskaya

Susan Chubinskaya has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods and compositions related to modulators of annexin and cartilage homeostasis
    Publication number: 20040053919
    Abstract: The present invention provides a method of treating a subject with arthritis or an arthritic disease or preventing arthritis or arthritic disease in a subject, comprising administering to the subject a therapeutically effective amount of an agent that attenuates annexin function. Also provided are various methods of screening for agents and genes that increase collagen synthesis, decrease collagen degradation, or reduce or delay apoptosis, and methods of using the identified agents or nucleic acids for attaining or maintaining cartilage homeostasis, promoting cartilage repair, increasing collagen synthesis, decreasing collagen degradation, or reducing or delaying apoptosis. The invention also provides methods of decreasing mineralization of vesicles derived from chondrocytes and of promoting endochondral bone growth using agents that attenuates annexin function.
    Type: Application
    Filed: September 11, 2003
    Publication date: March 18, 2004
    Inventors: Susan Chubinskaya, Jeff Hutchins, Juergen Mollenhauer, Francis X. Tavares, Stephen A. Thomson, Jennings F. Worley
  • Methods and compositions related to modulators of annexin and cartilage homeostasis
    Patent number: 6649366
    Abstract: The present invention provides a method of treating a subject with arthritis or an arthritic disease or preventing arthritis or arthritic disease in a subject, comprising administering to the subject a therapeutically effective amount of an agent that attenuates annexin function. Also provided are various methods of screening for agents and genes that increase collagen synthesis, decrease collagen degradation, or reduce or delay apoptosis, and methods of using the identified agents or nucleic acids for attaining or maintaining cartilage homeostasis, promoting cartilage repair, increasing collagen synthesis, decreasing collagen degradation, or reducing or delaying apoptosis. The invention also provides methods of decreasing mineralization of vesicles derived from chondrocytes and of promoting endochondral bone growth using agents that attenuates annexin function.
    Type: Grant
    Filed: December 21, 2000
    Date of Patent: November 18, 2003
    Assignee: SmithKline Beecham Corporation
    Inventors: Susan Chubinskaya, Jeff Hutchins, Juergen Mollenhauer, Francis X. Tavares, Stephen A. Thomson, Jennings F. Worley
  • Methods and compositions related to modulators of annexin and cartilage homeostasis
    Publication number: 20020052358
    Abstract: The present invention provides a method of treating a subject with arthritis or an arthritic disease or preventing arthritis or arthritic disease in a subject, comprising administering to the subject a therapeutically effective amount of an agent that attenuates annexin function. Also provided are various methods of screening for agents and genes that increase collagen synthesis, decrease collagen degradation, or reduce or delay apoptosis, and methods of using the identified agents or nucleic acids for attaining or maintaining cartilage homeostasis, promoting cartilage repair, increasing collagen synthesis, decreasing collagen degradation, or reducing or delaying apoptosis. The invention also provides methods of decreasing mineralization of vesicles derived from chondrocytes and of promoting endochondral bone growth using agents that attenuates annexin function.
    Type: Application
    Filed: December 21, 2000
    Publication date: May 2, 2002
    Inventors: Susan Chubinskaya, Jeff Hutchins, Juergen Mollenhauer, Francis X. Tavares, Stephen A. Thomson, Jennings F. Worley